A Thermodynamic Characterization of the Binding of Thrombin Inhibitors to Human Thrombin, Combining Biosensor Technology, Stopped-Flow Spectrophotometry, and Microcalorimetry

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1991 • 1,263 citations

Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system

1991 • 1,071 citations

Quantitative determination of surface concentration of protein with surface plasmon resonance using radiolabeled proteins

1991 • 1,037 citations

The Behavior and Significance of Slow‐Binding Enzyme Inhibitors

1988 • 828 citations

Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors

1997 • 556 citations

TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface

1999 • 306 citations

Significant discrepancies between van't Hoff and calorimetric enthalpies.

1995 • 289 citations

Kinetic and Concentration Analysis Using BIA Technology

1994 • 272 citations

Kinetic analysis of a protein antigen-antibody interaction limited by mass transport on an optical biosensor

1997 • 224 citations

Physical Chemistry: with Applications to the Life Sciences

1979 • 224 citations

Tight-binding inhibitors—III

1976 • 132 citations

Biosensor Analysis of Drug–Target Interactions: Direct and Competitive Binding Assays for Investigation of Interactions between Thrombin and Thrombin Inhibitors

2000 • 125 citations

The action of thrombin on peptide p-Nitroanilide substrates

1983 • 121 citations

The Importance of Enzyme Inhibition Kinetics for the Effect of Thrombin Inhibitors in a Rat Model of Arterial Thrombosis

1997 • 116 citations

Thermodynamic analysis of protein interactions with biosensor technology

1998 • 108 citations

Affinity analysis of non-steady-state data obtained under mass transport limited conditions using BIAcore technology

1999 • 101 citations

Kinetic Analysis of the Interaction between HIV-1 Protease and Inhibitors Using Optical Biosensor Technology

2000 • 72 citations

Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin

1991 • 68 citations

The Mechanism of Binding of Low-Molecular-Weight Active Site Inhibitors to Human α-Thrombin

1998 • 37 citations

Thrombin Inhibitors as Antithrombotic Agents: The Importance of Rapid Inhibition

1995 • 24 citations

Thermodynamics of Substrates and Reversible Inhibitors Binding to the Active Site Cleft of Human α-thrombin

1994 • 17 citations