The recognition event between virus and host cell receptor: a target for antiviral agents

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection

1986 • 1,828 citations

Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

1981 • 1,603 citations

Pathogenesis of Dengue: Challenges to Molecular Biology

1988 • 1,547 citations

Endocytosis and the recycling of plasma membrane.

1983 • 1,447 citations

Structure of a human common cold virus and functional relationship to other picornaviruses

1985 • 1,419 citations

THE STRUCTURE AND FUNCTION OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA VIRUS

1987 • 1,391 citations

Three-Dimensional Structure of Poliovirus at 2.9 Å Resolution

1985 • 1,253 citations

[47] Establishing homologies in protein sequences

1983 • 1,187 citations

Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

1988 • 1,151 citations

The major human rhinovirus receptor is ICAM-1

1989 • 1,134 citations

Cellular receptor for poliovirus: Molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily

1989 • 1,086 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes

1984 • 976 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

1984 • 936 citations

Receptor determinants of human and animal influenza virus isolates: Differences in receptor specificity of the H3 hemagglutinin based on species of origin

1983 • 908 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

1989 • 854 citations

Genome organization and transactivation of the human immunodeficiency virus type 2

1987 • 842 citations

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1987 • 827 citations

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

1982 • 826 citations

A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses

1989 • 825 citations

Structure of the catalytic and antigenic sites in influenza virus neuraminidase

1983 • 785 citations

A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection

1989 • 692 citations

Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity

1983 • 676 citations

Virus Entry into Animal Cells

1989 • 625 citations

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

1988 • 616 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

Antibody-enhanced dengue virus infection in primate leukocytes

1977 • 549 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus

1986 • 523 citations

Epstein-barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis

1987 • 493 citations

Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen

1987 • 485 citations

Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens

1988 • 470 citations

Is the Acetylcholine Receptor a Rabies Virus Receptor?

1982 • 466 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1988 • 425 citations

Epidermal Langerhans Cells-A Target for HTLV-III/LAV Infection

1987 • 414 citations

The CD4 antigen: Physiological ligand and HIV receptor

1988 • 413 citations

Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989 • 405 citations

Soluble CD4 molecules neutralize human immunodeficiency virus type 1

1988 • 403 citations

Protection of Cattle Against Foot-and-Mouth Disease by a Synthetic Peptide

1986 • 397 citations

The Cell Attachment Site on Foot-and-Mouth Disease Virus Includes the Amino Acid Sequence RGD (Arginine-Glycine-Aspartic Acid)

1989 • 389 citations

Epitopes of the CD4 Antigen and HIV Infection

1986 • 379 citations

Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the Fl or HA2 viral polypeptides

1980 • 357 citations

Identification of the residues in human CD4 critical for the binding of HIV

1989 • 357 citations

Identification of gp350 as the viral glycoprotein mediating attachment of Epstein-Barr virus (EBV) to the EBV/C3d receptor of B cells: sequence homology of gp350 and C3 complement fragment C3d

1987 • 341 citations

The Fc and not CD4 Receptor Mediates Antibody Enhancement of HIV Infection in Human Cells

1989 • 328 citations

Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14

1986 • 305 citations

Influenza C virus uses 9-O-acetyl-N-acetylneuraminic acid as a high affinity receptor determinant for attachment to cells.

1986 • 298 citations

Inhibition of VSV binding and infectivity by phosphatidylserine: Is phosphatidylserine a VSV-binding site?

1983 • 297 citations

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4

1988 • 294 citations

Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry.

1986 • 293 citations

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4

1988 • 277 citations

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1989 • 270 citations

Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity.

1986 • 261 citations

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

1988 • 253 citations

cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1.

1989 • 251 citations

Early events in cell-animal virus interactions

1973 • 250 citations

Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor

1985 • 249 citations

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues

1986 • 243 citations

A synthetic peptide vaccine involving the product of the pre-S(2) region of hepatitis B virus DNA: protective efficacy in chimpanzees.

1986 • 239 citations

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

1989 • 227 citations

Lymphocyte activation by HIV-1 envelope glycoprotein

1988 • 224 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Evidence for the direct involvement of the rhinovirus canyon in receptor binding.

1988 • 211 citations

Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus.

1978 • 210 citations

Receptor affinities as major determinants of enterovirus tissue tropisms in humans

1961 • 208 citations

Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors.

1984 • 201 citations

HIV-1 GP120-mediated immune suppression and lymphocyte destruction in the absence of viral infection.

1989 • 201 citations

A Polypeptide Containing 55 Amino Acid Residues Coded by the Pre-S Region of Hepatitis B Virus Deoxyribonucleic Acid Bears the Receptor for Polymerized Human as Well as Chimpanzee Albumins

1984 • 197 citations

Identification of an epitope in the major envelope protein of Epstein-Barr virus that mediates viral binding to the B lymphocyte EBV receptor (CR2)

1989 • 191 citations

Conformational change in the floor of the human rhinovirus canyon blocks adsorption to HeLa cell receptors

1989 • 190 citations

Interactions of Animal Viruses with Cell Surface Receptors

1985 • 178 citations

Viral receptors of the immunoglobulin superfamily

1989 • 178 citations

Location and Chemical Synthesis of a Binding Site for HIV-1 on the CD4 Protein

1988 • 178 citations

Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding

1988 • 175 citations

Initial Stages in Infection with Animal Viruses

1982 • 173 citations

Cloning of HTLV-4 and its relation to simian and human immunodeficiency viruses

1987 • 167 citations

Synthetic CD4 Peptide Derivatives That Inhibit HIV Infection and Cytopathicity

1988 • 164 citations

Effects of anti-gp120 monoclonal antibodies on CD4 receptor binding by the env protein of human immunodeficiency virus type 1

1988 • 163 citations

Isolation of a monoclonal antibody that blocks attachment of the major group of human rhinoviruses

1986 • 162 citations

Poliovirus Host Range Is Determined by a Short Amino Acid Sequence in Neutralization Antigenic Site I

1988 • 162 citations

Oligopeptides that specifically inhibit membrane fusion by paramyxoviruses: Studies on the site of action

1983 • 162 citations

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

1988 • 160 citations

Mechanism of neutralization of influenza virus by secretory IgA is different from that of monomeric IgA or IgG.

1985 • 159 citations

Restoration of specific myxovirus receptors to asialoerythrocytes by incorporation of sialic acid with pure sialyltransferases.

1979 • 156 citations

Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis.

1988 • 150 citations

Human liver plasma membranes contain receptors for the hepatitis B virus pre-S1 region and, via polymerized human serum albumin, for the pre-S2 region

1989 • 148 citations

Mysteries of HIV: challenges for therapy and prevention

1988 • 148 citations

Amino Acid Sequence Similarity Between Rabies Virus Glycoprotein and Snake Venom Curaremimetic Neurotoxins

1984 • 147 citations

Vaccinia virus-infected cells release a novel polypeptide functionally related to transforming and epidermal growth factors.

1985 • 146 citations

Monoclonal anti-Fc receptor IgG blocks antibody enhancement of viral replication in macrophages

1981 • 143 citations

HIV-Infected Cells Are Killed by rCD4-Ricin A Chain

1988 • 141 citations

beta2 Microglobulin Enhances the Infectivity of Cytomegalovirus and When Bound to the Virus Enables Class I HLA Molecules To Be Used as a Virus Receptor

1987 • 140 citations

Characterization of Membrane Components of the Erythrocyte Involved in Vesicular Stomatitis Virus Attachment and Fusion at Acidic pH

1987 • 140 citations

Epidermal growth factor receptor occupancy inhibits vaccinia virus infection

1985 • 137 citations

Synergism Between HIV gp120 and gp120-Specific Antibody in Blocking Human T Cell Activation

1989 • 135 citations

Human immunodeficiency virus induces phosphorylation of its cell surface receptor

1988 • 133 citations

Conservation of the putative receptor attachment site in picornaviruses

1988 • 131 citations

Generation and characterization of monoclonal antibodies to the putative CD4-binding domain of human immunodeficiency virus type 1 gp120

1989 • 129 citations

Homology of human T-cell leukaemia virus envelope gene with class I HLA gene

1983 • 126 citations

CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis

1987 • 125 citations

The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain.

1987 • 122 citations

The α-anomeric form of sialic acid is the minimal receptor determinant recognized by reovirus

1989 • 121 citations

Different cell-surface receptor determinants of antigenically similar influenza virus hemagglutinins.

1981 • 120 citations

A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.

1988 • 120 citations

Sequence of reovirus haemagglutinin predicts a coiled-coil structure

1985 • 117 citations

Polyoma virus recognizes specific sialyloligosaccharide receptors on host cells

1981 • 117 citations

Comparison of human, simian, and bovine rotaviruses for requirement of sialic acid in hemagglutination and cell adsorption

1989 • 114 citations

Functional Interaction and Partial Homology Between Human Immunodeficiency Virus and Neuroleukin

1987 • 109 citations

In vitro growth characteristics of simian T-lymphotropic virus type III.

1985 • 104 citations

Early interaction between animal viruses and cells.

1974 • 103 citations

Biological characterization of a simian immunodeficiency virus-like retrovirus (HTLV-IV): evidence for CD4-associated molecules required for infection

1988 • 103 citations

Structural similarities between the mammalian beta-adrenergic and reovirus type 3 receptors.

1985 • 100 citations

Glycophorin is the reovirus receptor on human erythrocytes

1987 • 100 citations

Similarity between the vaccinia virus 19K early protein and epidermal growth factor

1985 • 95 citations

Mouse Ia antigens are receptors for lactate dehydrogenase virus

1984 • 94 citations

Recognition of monovalent sialosides by influenza virus H3 hemagglutinin

1987 • 93 citations

Monoclonal antibodies which block cellular receptors of poliovirus

1984 • 91 citations

Involvement of Gangliosides in Rabies Virus Infection

1986 • 91 citations

Association of human T-cell leukaemia/lymphoma virus with the Tac antigen marker for the human T-cell growth factor receptor

1983 • 90 citations

Development of biologically active peptides based on antibody structure.

1989 • 90 citations

Monoclonal anti-idiotypic antibody mimics the CD4 receptor and binds human immunodeficiency virus.

1987 • 85 citations

Interaction of Viruses with Cell Surface Receptors

1982 • 84 citations

Epitope mapping of the human immunodeficiency virus type 1 gp120 with monoclonal antibodies

1988 • 83 citations

Cell receptors for the mammalian reovirus. II. Monoclonal anti-idiotypic antibody blocks viral binding to cells.

1983 • 79 citations

Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors.

1986 • 75 citations

Molecular mimicry revisited

1987 • 72 citations

Interaction of West Nile virus with primary murine macrophages: role of cell activation and receptors for antibody and complement

1986 • 72 citations

A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus

1987 • 68 citations

Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptor

1987 • 67 citations

Effects of mutations in hyperconserved regions of the extracellular glycoprotein of human immunodeficiency virus type 1 on receptor binding

1989 • 61 citations

Cell surface influenza haemagglutinin can mediate infection by other animal viruses.

1985 • 52 citations

Infection of Cultured Rat Myotubes and Neurons from the Spinal Cord by Rabies Virus

1986 • 52 citations

Different rhinovirus serotypes neutralized by antipeptide antibodies

1987 • 47 citations

Antipeptide monoclonal antibodies inhibit the binding of rabies virus glycoprotein and alpha-bungarotoxin to the nicotinic acetylcholine receptor

1988 • 45 citations

THE RELATIONSHIP OF THE INFLUENZA VIRUS INHIBITORY ACTIVITY OF GLYCOPROTEINS TO THEIR MOLECULAR SIZE AND SIALIC ACID CONTENT

1969 • 42 citations

HLA-DR is involved in the HIV-1 binding site on cells expressing MHC class II antigens.

1988 • 41 citations

A 113-Amino Acid Fragment of CD4 Produced in Escherichia Coli Blocks Human Immunodeficiency Virus-induced Cell Fusion

1989 • 40 citations

Role of receptor-binding activity of the viral hemagglutinin molecule in the presentation of influenza virus antigens to helper T cells

1987 • 38 citations

Mechanisms of Neutralization of Influenza Virus by IgM

1985 • 37 citations

Effect of Enzymes on the Attachment of Influenza and Encephalomyocarditis Viruses to Erythrocytes

1981 • 33 citations

Homology of adenoviral E3 glycoprotein with HLA-DR heavy chain.

1984 • 30 citations

Immunological and structural homology between human T-cell leukemia virus type I envelope glycoprotein and a region of human interleukin-2 implicated in binding the beta receptor

1988 • 30 citations

Finding the receptors

1989 • 22 citations

Structural features of CD4 required for binding to HIV.

1989 • 19 citations

Molecular decoys: ligand-binding recombinant proteins protect mice from curarimimetic neurotoxins.

1988 • 17 citations

The vero cell receptor for the hepatitis B virus small S protein is a sialoglycoprotein

1988 • 14 citations

Synthetic peptides of neurotoxins and rabies virus glycoprotein behave as antagonists in a functional assay for the acetylcholine receptor.

1989 • 14 citations

Virus receptors and cell tropisms

1986 • 13 citations

Viral receptors and drug design

1988 • 10 citations

A vaccine for the common cold?

1987 • 10 citations