Cholecystokinin in the Rostral Ventromedial Medulla Mediates Opioid-Induced Hyperalgesia and Antinociceptive Tolerance

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Quantitative assessment of tactile allodynia in the rat paw

1994 • 6,953 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Textbook of pain

1999 • 2,566 citations

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Central nervous system mechanisms of pain modulation

2006 • 717 citations

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

1983 • 582 citations

The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat

1983 • 499 citations

Immunochemical studies on cholecystokinin. I. Development of sequence-specific radioimmunoassays for porcine triacontatriapeptide cholecystokinin.

1978 • 350 citations

Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance

2000 • 340 citations

Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance

2001 • 337 citations

Progressive Enhancement of Delayed Hyperalgesia Induced by Repeated Heroin Administration: A Sensitization Process

2001 • 304 citations

Anatomy and physiology of a nociceptive modulatory system

1985 • 287 citations

The selective CCK-B receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat

1990 • 270 citations

Potentiation of Opiate Analgesia and Apparent Reversal of Morphine Tolerance by Proglumide

1984 • 269 citations

Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin

2001 • 269 citations

The role of CCK, caerulein, and CCK antagonists in nociception

1989 • 246 citations

Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat

2000 • 209 citations

Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat

1992 • 195 citations

Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.

1988 • 194 citations

Opiate tolerance to daily heroin administration: an apparent phenomenon associated with enhanced pain sensitivity

1999 • 185 citations

Intrathecal high dose morphine produces hyperalgesia in the rat

1981 • 173 citations

PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.

1990 • 169 citations

Neural Basis for the Hyperalgesic Action of Cholecystokinin in the Rostral Ventromedial Medulla

2004 • 156 citations

Immunohistochemical studies on cholecystokinin (CCK)-immunoreactive neurons in the rat using sequence specific antisera and with special reference to the caudate nucleus and primary sensory neurons.

1988 • 150 citations

Circuitry Underlying Antiopioid Actions of Cholecystokinin Within the Rostral Ventromedial Medulla

2001 • 126 citations

Increased release of immunoreactive cholecystokinin octapeptide by morphine and potentiation of μ-opioid analgesia by CCKB receptor antagonist L-365,260 in rat spinal cord

1993 • 108 citations

Localization and opiate receptor binding of enkephalin, CCK and ACTH/β-endorphin in the rat central nervous system

1981 • 105 citations

Trigeminal and dorsal root ganglion neurons express CCK receptor binding sites in the rat, rabbit, and monkey: possible site of opiate- CCK analgesic interactions

1992 • 103 citations

Pronounced changes in the activity of nociceptive modulatory neurons in the rostral ventromedial medulla in response to prolonged thermal noxious stimuli

1994 • 103 citations

Cholecystokinin as a factor in the enhanced potency of spinal morphine following carrageenin inflammation

1993 • 96 citations

Characterization of Biphasic Modulation of Spinal Nociceptive Transmission by Neurotensin in the Rat Rostral Ventromedial Medulla

1997 • 85 citations

Tolerance to morphine analgesia: decreased multiplicative interaction between spinal and supraspinal sites

1984 • 74 citations

Involvement of local cholecystokinin in the tolerance induced by morphine microinjections into the periaqueductal gray of rats

2003 • 64 citations

On the Origin of Striatal Cholecystokinin Release: Studies with In Vivo Microdialysis

1994 • 61 citations

Cholecystokinin-octapeptide antagonizes morphine analgesia in periaqueductal gray of the rat

1989 • 60 citations

The CCK-B receptor antagonist Cl 988 reverses tolerance to morphine in rats

1994 • 60 citations

Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception

1994 • 59 citations

The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Efficacy of Morphine in Humans with Chronic Benign Pain

1998 • 58 citations

Increases of CCK mRNA and peptide in different brain areas following acute and chronic administration of morphine

1993 • 56 citations

Accelerated expression of cholecystokinin gene in the brain of rats rendered tolerant to morphine

1992 • 52 citations

Potassium evoked in vivo release of substance P in rat caudate nucleus measured using a new technique of brain dialysis and an improved substance P-radioimmunoassay.

1983 • 48 citations

Neuregulin-1 proteins in rat brain and transfected cells are localized to lipid rafts

2001 • 47 citations

Modulation of visceral hyperalgesia by morphine and cholecystokinin from the rat rostroventral medial medulla

2003 • 46 citations

Chronic intracerebroventricular infusion of the antiopioid peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), downregulates mu opioid binding sites in rat brain

1993 • 42 citations

Differential release of cholecystokinin by morphine in rat spinal cord

1998 • 39 citations

Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors.

1996 • 39 citations

Reversal of tolerance to morphine but no potentiation of morphine-induced analgesia by antiserum against cholecystokinin octapeptide

1986 • 38 citations

Involvement of spinal cholecystokininB receptors in mediating neurotensin hyperalgesia from the medullary nucleus raphe magnus in the rat.

1996 • 34 citations

?2-opioid receptor mediation of morphine-induced CCK release in the frontal cortex of the freely moving rat

1999 • 26 citations

The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of Dihydrocodeine

2003 • 24 citations

Effects of intracerebroventricular administration of the CCK1 receptor antagonist devazepide on food intake in rats

2002 • 22 citations

δ-Opioid receptor-mediated increase in cortical extracellular levels of cholecystokinin-like material by subchronic morphine in rats

2000 • 21 citations

Morphine‐induced in vivo release of spinal cholecystokinin is mediated by δ‐opioid receptors – effect of peripheral axotomy

2001 • 20 citations

Measurement of cholecystokinin release in vivo in the rat spinal dorsal horn

1999 • 19 citations

The Cholecystokinin Antagonist Proglumide Has an Analgesic Effect in Chronic Pancreatitis

2000 • 17 citations

Effect of CCK1 and CCK2 receptor blockade on amphetamine-stimulated exploratory behavior and sensitization to amphetamine

2003 • 15 citations