The Significance of RAS Guanine Nucleotide Exchange Factor, Son of Sevenless Protein, in Renal Cell Carcinoma Cell Lines

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas.

1994 • 469 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma.

1995 • 304 citations

Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas.

1989 • 229 citations

Enhanced expression of c-myc and epidermal growth factor receptor (C-erbB-1) genes in primary human renal cancer.

1988 • 126 citations

Overexpression of the Grb2 gene in human breast cancer cell lines.

1994 • 100 citations

Mutations of the ras gene product p21 that abolish guanine nucleotide binding.

1986 • 91 citations

Infrequent ras Oncogene Point Mutations in Renal Cell Carcinoma

1990 • 68 citations

Activated H-ras oncogenes in human kidney tumors.

1988 • 62 citations

Establishment of three human renal cell carcinoma cell lines (SMKT-R-1, SMKT-R-2, and SMKT-R-3) and their characters

1989 • 47 citations

Inhibition of SDC25 C-domain-induced guanine-nucleotide exchange by guanine ring binding domain mutants of v-H-ras.

1993 • 40 citations

Cellular ras activity and tumor cell proliferation

1987 • 38 citations

A specific protein, p92, detected in flat revertants derived from NIH/3T3 transformed by human activated c-Ha-ras oncogene

1990 • 22 citations

Suppression of various human tumor cell lines by a dominant negative H-ras mutant.

1994 • 20 citations

Resistance of NIH3T3 Cells to v-fes Transformation Induced by a Dominant Negative H-ras Mutant

1993 • 10 citations

[Inhibition of ras-dependent transformation by using dominant negative ras mutant N116Y].

1995 • 1 citations