Nuclear Accumulation of IE62, the Varicella-Zoster Virus (VZV) Major Transcriptional Regulatory Protein, Is Inhibited by Phosphorylation Mediated by the VZV Open Reading Frame 66 Protein Kinase
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References (70)
Rapid and efficient site-specific mutagenesis without phenotypic selection.
1985 • 7,573 citations
[19] Rapid and efficient site-specific mutagenesis without phenotypic selection
1987 • 5,413 citations
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
1995 • 2,534 citations
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1
1995 • 2,199 citations
Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins
1974 • 1,479 citations
The Complete DNA Sequence of Varicella-Zoster Virus
1986 • 1,425 citations
Nucleocytoplasmic transport: signals, mechanisms and regulation
1997 • 987 citations
Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.
1975 • 616 citations
Regulation of protein transport to the nucleus: central role of phosphorylation
1996 • 429 citations
Nucleocytoplasmic Transport: The Last 200 Nanometers
1998 • 361 citations
The herpes simplex virus 1 protein kinase U S 3 is required for protection from apoptosis induced by the virus
1997 • 271 citations
Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA
1980 • 251 citations
Identification of a Yeast Karyopherin Heterodimer That Targets Import Substrate to Mammalian Nuclear Pore Complexes
1995 • 210 citations
p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins.
1991 • 203 citations
The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene
1991 • 164 citations
The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles
1992 • 164 citations
Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus
1989 • 163 citations
The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse
1998 • 154 citations
SV40 Large Tumor Antigen Nuclear Import Is Regulated by the Double-stranded DNA-dependent Protein Kinase Site (Serine 120) Flanking the Nuclear Localization Sequence
1997 • 127 citations
Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2.
1993 • 120 citations
Herpesvirus Transcription and Its Regulation
1991 • 118 citations
The US3-encoded protein kinase from pseudorabies virus affects egress of virions from the nucleus
1995 • 116 citations
Mapping of two varicella-zoster virus-encoded genes that activate the expression of viral early and late genes
1989 • 114 citations
The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF 61, are associated with purified virus particles
1995 • 109 citations
Regulation of varicella-zoster virus gene expression in human T lymphocytes
1992 • 103 citations
Cyclin-dependent Kinase Site-regulated Signal-dependent Nuclear Localization of the SWI5 Yeast Transcription Factor in Mammalian Cells
1995 • 100 citations
The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence.
1996 • 96 citations
Negative charge at the casein kinase II site flanking the nuclear localization signal of the SV40 large T-antigen is mechanistically important for enhanced nuclear import.
1994 • 94 citations
Phosphorylation of varicella-zoster virus open reading frame (ORF) 62 regulatory product by viral ORF 47-associated protein kinase
1994 • 92 citations
Varicella-Zoster Virus (VZV) Virion-Associated Transactivator Open Reading Frame 62 Protein Enhances the Infectivity of VZV DNA
1994 • 84 citations
Cell lines containing varicella-zoster virus open reading frame 62 and expressing the "IE" 175 protein complement ICP4 mutants of herpes simplex virus type 1
1988 • 83 citations
UL34, the target of the herpes simplex virus U(S)3 protein kinase, is a membrane protein which in its unphosphorylated state associates with novel phosphoproteins
1992 • 83 citations
A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain
1993 • 79 citations
Varicella-zoster virus
1991 • 76 citations
The varicella-zoster virus (VZV) open reading frame 47 (ORF47) protein kinase is dispensable for viral replication and is not required for phosphorylation of ORF63 protein, the VZV homolog of herpes simplex virus ICP22
1995 • 76 citations
Varicella-zoster virus open reading frame 10 protein, the herpes simplex virus VP16 homolog, transactivates herpesvirus immediate-early gene promoters
1993 • 75 citations
The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4, pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promoters
1991 • 74 citations
The substrate specificity of the protein kinase induced in cells infected with herpesviruses: Studies with synthetic substatres indicate structural requirements distinct from other protein kinases
1986 • 71 citations
Characterization of regulatory functions of the varicella-zoster virus gene 63-encoded protein
1992 • 71 citations
Viral Aspects of Protein Phosphorylation
1988 • 66 citations
Inactivation of Glycoprotein gE and Thymidine Kinase or the US3-Encoded Protein Kinase Synergistically Decreases in Vivo Replication of Pseudorabies Virus and the Induction of Protective Immunity
1994 • 63 citations
The Protein Kinase Encoded in the Short Unique Region of Pseudorabies Virus: Description of the Gene and Identification of its Product in Virions and in Infected Cells
1990 • 60 citations
Characterization of a potent varicella-zoster virus-encoded trans-repressor
1991 • 60 citations
Characterization of the regulatory functions of varicella-zoster virus open reading frame 4 gene product
1993 • 59 citations
Identification and characterization of a varicella-zoster virus DNA-binding protein by using antisera directed against a predicted synthetic oligopeptide
1988 • 52 citations
Further definition of the substrate specificity of the alpha-herpesvirus protein kinase and comparison with protein kinases A and C
1991 • 52 citations
The varicella-zoster virus ORF66 protein induces kinase activity and is dispensable for viral replication
1996 • 52 citations
A herpes simplex virus type 1 recombinant with both copies of the Vmw175 coding sequences replaced by the homologous varicella-zoster virus open reading frame
1990 • 51 citations
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication
1996 • 50 citations
Characterization of the putative protein kinases specified by varicella-zoster virus genes 47 and 66
1994 • 47 citations
Mutational analysis of varicella-zoster virus major immediate-early protein IE62
1995 • 47 citations
Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4
1996 • 45 citations
Monoclonal antibody to immediate early protein encoded by varicella-zoster virus gene 62
1990 • 45 citations
Varicella-zoster virus: overview and clinical manifestations.
1996 • 43 citations
The pathogenicity of a US3 protein kinase-deficient mutant of herpes simplex virus type 2 in mice
1993 • 41 citations
Regulated Nuclear Localization of the Varicella‐Zoster Virus Major Regulatory Protein, IE62
1998 • 40 citations
Pseudorabies virus infections in pigs. Role of viral proteins in virulence, pathogenesis and transmission.
1997 • 39 citations
Transcription from varicella-zoster virus gene 67 (glycoprotein IV)
1992 • 38 citations
Identification of a target protein of US3 protein kinase of herpes simplex virus type 2
1994 • 38 citations
Molecular Mechanisms of Nuclear Protein Transport
1997 • 36 citations
The transcriptional activation domain of varicella-zoster virus open reading frame 62 protein is not conserved with its herpes simplex virus homolog
1993 • 35 citations
The DNA binding domain of the Varicella-zoster virus gene 62 protein interacts with multiple sequences which are similar to the binding site of the related protein of herpes simplex virus type 1
1993 • 31 citations
Pseudorabies Virus EP0 Is Functionally Homologous to Varicella-Zoster Virus ORF61 Protein and Herpes Simplex Virus Type 1 ICP0
1995 • 26 citations
The US3 protein kinase of herpes simplex virus type 2 is associated with phosphorylation of the UL12 alkaline nuclease in vitro
1995 • 26 citations
The herpesvirus protein kinase: a new departure in protein phosphorylation?
1988 • 21 citations
Expression in yeast of binding regions of karyopherins α and β inhibits nuclear import and cell growth
1996 • 20 citations
Association of a major transcriptional regulatory protein, ICP4, of herpes simplex virus type 1 with the plasma membrane of virus-infected cells
1991 • 11 citations
Soluble Factors Required for Nuclear Protein Import
1995 • 10 citations
Delineation of a Sequence Required for Nuclear Localization of the Protein Encoded by Varicella-zoster Virus Gene 61
1994 • 9 citations
Initial characterization of the membrane-associated form of ICP4 of herpes simplex virus type 1
1995 • 1 citations
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