Human memory T cell differentiation into Th2-like effector cells is dependent on IL-4 and CD28 stimulation and inhibited by TCR ligation

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Human naive and memory T cells

1988 • 793 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Divergent T-cell cytokine patterns in inflammatory arthritis.

1994 • 388 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes

1996 • 379 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity.

1991 • 201 citations

Monocyte Dependence of Pokeweed Mitogen-Induced Differentiation of Immunoglobulin-Secreting Cells from Human Peripheral Blood Mononuclear Cells

1979 • 197 citations

Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3.

1987 • 188 citations

Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets.

1995 • 159 citations

Stability of T_h1 and T_h2 populations

1995 • 158 citations

Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells.

1990 • 144 citations

Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.

1995 • 144 citations

Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit.

1995 • 140 citations

B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells.

1994 • 136 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

Interleukin (IL)‐4 production by human T cells: differential regulation of IL‐4 vs. IL‐2 production

1992 • 126 citations

CD28 activation promotes Th2 subset differentiation by human CD4⁺ cells

1995 • 122 citations

CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite.

1994 • 111 citations

The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro.

1995 • 106 citations

Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: Relative roles of interleukin (IL)-4 and IL-10

1993 • 101 citations

A minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4-secreting cells.

1994 • 82 citations

Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation.

1995 • 61 citations

Regulation of human T lymphocyte mitogenesis by antibodies to CD3.

1986 • 47 citations

Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.

1987 • 46 citations

TCR-independent activation of human CD4+ 45RO- T cells by anti-CD28 plus IL-2: Induction of clonal expansion and priming for a Th2 phenotype.

1996 • 25 citations