Genetic Immunization with Glycoprotein 63 cDNA Results in a Helper T Cell Type 1 Immune Response and Protection in a Murine Model of Leishmaniasis

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Genetic immunization is a simple method for eliciting an immune response

1992 • 1,505 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

1993 • 1,122 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 • 937 citations

DNA–based immunization by in vivo transfection of dendritic cells

1996 • 849 citations

Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.

1996 • 764 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses.

1994 • 550 citations

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

1996 • 524 citations

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

1992 • 480 citations

CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.

1998 • 457 citations

Vaccination with DNA Encoding the Immunodominant LACK Parasite Antigen Confers Protective Immunity to Mice Infected with Leishmania major

1997 • 359 citations

Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis

1998 • 349 citations

Antigen Presentation by Dendritic Cells after Immunization with DNA Encoding a Major Histocompatibility Complex Class II–restricted Viral Epitope

1997 • 326 citations

Protection against mycoplasma infection using expression-library immunization

1995 • 296 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function

1991 • 286 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

Cytokine gene expression in epidermis with biological effects following injection of naked DNA

1995 • 248 citations

T-cell and cytokine responses in leishmaniasis

1993 • 221 citations

Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63.

1993 • 218 citations

Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes.

1987 • 212 citations

IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides.

1996 • 208 citations

Expression of naked DNA in human, pig, and mouse skin.

1996 • 198 citations

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

1995 • 179 citations

Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major.

1995 • 171 citations

Microbial products induce autoimmune disease by an IL-12-dependent pathway.

1997 • 170 citations

Molecular cloning of the major surface antigen of leishmania.

1988 • 169 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease.

1996 • 163 citations

The role of the innate immune response in Th1 cell development following Leishmania major infection

1995 • 123 citations

Gamma interferon response in secondary Leishmania major infection: role of CD8+ T cells

1993 • 121 citations

Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes.

1990 • 91 citations

A sensitive immunochemical assay for biologically active MuIFN-γ

1987 • 79 citations

Survivability and Infectivity of Viscerotropic Leishmania tropica from Operation Desert Storm Participants in Human Blood Products Maintained Under Blood Bank Conditions

1993 • 78 citations

Modification of GP63 genes from diverse species of Leishmania for expression of recombinant protein at high levels in Escherichia coli

1991 • 39 citations