The Serotonin Syndrome

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

1994 • 2,935 citations

The serotonin syndrome

1991 • 1,317 citations

Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

1992 • 733 citations

The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-Propylamino) tetralin in the rat

1984 • 678 citations

STUDIES IN VIVO ON THE RELATIONSHIP BETWEEN BRAIN TRYPTOPHAN, BRAIN 5‐HT SYNTHESIS AND HYPERACTIVITY IN RATS TREATED WITH A MONOAMINE OXIDASE INHIBITOR AND L‐TRYPTOPHAN

1971 • 667 citations

An animal behavior model for studying central serotonergic synapses

1976 • 555 citations

Fluvoxamine

1986 • 493 citations

POTENTIATION OF THE ANTIDEPRESSIVE EFFECT OF A MONOAMINE-OXIDASE INHIBITOR BY TRYPTOPHAN

1963 • 340 citations

'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA

1987 • 306 citations

(-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists

1986 • 301 citations

Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat.

1984 • 299 citations

Motor effects of serotonin in the central nervous system

1980 • 259 citations

Differential effects of 5-hydroxytryptamine1A selective drugs on the 5-HT behavioral syndrome

1986 • 244 citations

Molecular biology of 5-HT receptors

1989 • 214 citations

Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol

1984 • 206 citations

The pharmacology of the behavioral and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

1987 • 197 citations

Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor

1960 • 181 citations

Serotonin syndrome

1995 • 177 citations

Potentiation of a monoamine oxidase inhibitor by tryptophan

1969 • 167 citations

Multiple Severe Complications From Recreational Ingestion of MDMA ('Ecstasy')

1987 • 154 citations

THE EFFECTS OF PUTATIVE 5‐HYDROXYTRYPTAMINE ANTAGONISTS ON THE BEHAVIOUR PRODUCED BY ADMINISTRATION OF TRANYLCYPROMINE AND L‐TRYPTOPHAN OR TRANYLCYPROMINE AND L‐DOPA TO RATS

1978 • 152 citations

Ecstasy, 3–4 Methylenedioxymethamphetamine (MDMA), a Fatality Associated with Coagulopathy and Hyperthermia

1991 • 143 citations

Central-Nervous-System Effects of Ingestion of L-Tryptophan by Normal Subjects

1962 • 142 citations

Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines

1969 • 136 citations

Possible development of the serotonin syndrome in man

1982 • 132 citations

Combined MAOI-Tricyclic Antidepressant Treatment

1981 • 132 citations

The role of brain dopamine in the hyperactivity syndrome produced by increased 5-hydroxytryptamine synthesis in rats

1974 • 129 citations

(−)-Propranolol inhibits the behavioural responses of rats to increased 5-hydroxytryptamine in the central nervous system

1976 • 125 citations

Hyperthermia in Psychostimulant Overdose

1994 • 115 citations

The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease

1994 • 114 citations

MONOAMINE OXIDASE INHIBITORS AND ANAESTHESIA

1988 • 112 citations

Adverse consequences of fluoxetine-MAOI combination therapy.

1990 • 112 citations

Ecstasy-fueled 'rave' parties become dances of death for English youths

1992 • 109 citations

Molecular Basis of Buspirone's Anxiolytic Action

1991 • 102 citations

The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice

1969 • 97 citations

A Comparison of Electroconvulsive Therapy and Combined Phenelzine-Amitriptyline in Refractory Depression

1978 • 96 citations

Toxic reaction following the combined administration of fluoxetine and l-tryptophan: Five case reports

1986 • 94 citations

Possible Monoamine Oxidase Inhibitor-Serotonin Uptake Inhibitor Interaction

1993 • 90 citations

Dangerous Potentiation of Pethidine by Iproniazid, and its Treatment

1960 • 90 citations

Controlled trial of trimipramine, monoamine oxidase inhibitors, and combined treatment in depressed outpatients.

1979 • 90 citations

Serotonin syndrome versus neuroleptic malignant syndrome as a cause of death.

1989 • 81 citations

FATAL TOXIC ENCEPHALITIS OCCURRING DURING IPRONIAZID THERAPY IN PULMONARY TUBERCULOSIS

1955 • 78 citations

Monoamine Oxidase Inhibitors and Narcotic Analgesics

1987 • 76 citations

Potentiation of Pethidine

1960 • 74 citations

Blockade of 5-hydroxytryptamine receptors in the central nervous system by β-adrenoceptor antagonists

1977 • 70 citations

Sertraline Intoxication in a Child

1994 • 70 citations

Myoclonus and ocular oscillations induced by <scp>L</scp>‐tryptophan

1982 • 69 citations

Serotonin syndrome caused by a moclobemide-clomipramine interaction.

1993 • 67 citations

ALARMING REACTION TO PETHIDINE IN PATIENTS ON PHENELZINE

1962 • 65 citations

An update of recent moclobemide interaction data

1993 • 63 citations

The pioneer spirit.

1970 • 62 citations

The Serotonin Syndrome

1986 • 61 citations

monoamine oxidase inhibitors revisited

1989 • 60 citations

Toxic Effects of Iproniazid in a Patient with Angina

1958 • 59 citations

A COMPARISON OF THE EFFECTS OF IMIPRAMINE, TRIMIPRAMINE, AND SOME OTHER DRUGS IN RABBITS TREATED WITH A MONOAMINE OXIDASE INHIBITOR

1965 • 56 citations

A Case of Mao Inhibitor/MDMA Interaction: Agony After Ecstasy

1987 • 50 citations

POTENTIATION OF AMPHETAMINE AND PETHIDINE BY MONOAMINEOXIDASE INHIBITORS

1963 • 49 citations

New Data Intensify the Agony Over Ecstasy

1988 • 49 citations

Dangers of Monoamine Oxidase Inhibitors

1962 • 49 citations

Combined monoamine oxidase inhibitor-tricyclic antidepressant treatment: a pilot study

1980 • 47 citations

Toxicity Secondary to Meperidine in Patients on Monoamine Oxidase Inhibitors

1981 • 47 citations

Another death from Ecstacy.

1992 • 46 citations

Dangerous Potentiation of Meperidine Hydrochloride by Pargyline Hydrochloride

1964 • 45 citations

Case report of a toxic reaction from a combination of tryptophan and phenelzine

1984 • 44 citations

Drug Interactions with Clomipramine (Anafranil)

1973 • 42 citations

Sertraline-Phenelzine Drug Interaction: A Serotonin Syndrome Reaction

1994 • 42 citations

Toxic reactions to the combination of monoamine oxidase inhibitors and tryptophan

1985 • 42 citations

REACTIONS DUE TO THE COMBINATION OF MONOAMINEOXIDASE INHIBITORS WITH THYMOLEPTICS, PETHIDINE, OR METHYLAMPHETAMINE

1963 • 42 citations

Prospective evaluation of the serotonin syndrome in depressed inpatients treated with clomipramine

1993 • 40 citations

Side-effects of Phenelzine

1960 • 39 citations

Interactions of a non-selective monoamine oxidase inhibitor, phenelzine, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake

1984 • 38 citations

Comparison of the effects of morphine, pethidine and pentazocine in rabbits pretreated with a monoamine oxidase inhibitor

1971 • 38 citations

Fluoxetine and Selegiline – Lack of Significant Interaction

1994 • 37 citations

Reduction of the central effects of tryptophan by a decarboxylase inhibitor

1964 • 35 citations

Imipramine-Tranylcypromine Incompatibility

1963 • 35 citations

Pethidine and Phenelzine

1962 • 35 citations

Role of brain monoamines in the interaction between pethidine and tranylcypromine

1971 • 30 citations

Fatal disseminated intravascular coagulation following a monoamine oxidase inhibitor/tricyclic interaction

1987 • 29 citations

ATROPINE-LIKE POISONING DUE TO TRANQUILIZING AGENTS

1960 • 28 citations

The hazards of use of monoamine oxidase inhibitors in disturbed adolescents.

1971 • 27 citations

Disseminated Intravascular Coagulation and Acute Myoglobinuric Renal Failure

1991 • 27 citations

Fluoxetine and the serotonin syndrome

1994 • 27 citations

Dextromethorphan-monoamine oxidase inhibitor interaction in rabbits

1973 • 27 citations

The Serotonin Syndrome in a Patient Receiving Sertraline After an Ankle Block

1994 • 24 citations

Interactions of non-selective monoamine oxidase inhibitors, tranylcypromine and nialamide, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake

1984 • 24 citations

Serotonin Syndrome: A Case Report

1986 • 22 citations

Myoclonus, Hyperreflexia and Diaphoresis in Patients on Phenelzine-Tryptophan Combination Treatment

1985 • 21 citations

Possible Synergistic Effects of the New Thymoleptics in Connection with Poisoning

1961 • 20 citations

REACTIONS TO OTHER DRUGS IN PATIENTS TAKING MONOAMINE-OXIDASE INHIBITORS

1962 • 19 citations

Possible interaction between sertraline and tranylcypromine.

1993 • 19 citations

Neuroleptic influence on hyperthermia induced by 5-hydroxytryptophan and p-methoxy-amphetamine in MAOI-pretreated rabbits

1979 • 16 citations

The evidence for the involvement of the 5-HT1A receptor in 5-HT syndrome induced in mice by tryptamine.

1989 • 16 citations

TRANSIENT BRAIN SYNDROME AS A NON-FATAL REACTION TO COMBINED PARGYLINE IMIPRAMINE TREATMENT

1964 • 16 citations

Toxic somatic and psychopathologic reactions to antidepressant drugs.

1961 • 15 citations

Adverse drug reaction following treatment with monoamine oxidase inhibitors and imipramine and similar drugs: report of two cases--one successfully treated with chlorpromazine.

1965 • 7 citations

Toxicity by interaction of tricyclic antidepressant and monoamine oxidase inhibitor.

1972 • 3 citations

[On incompatibility between monoamine oxidase inhibitors and imipramin (with remarks on the work of O. Eichhorn "Remarks on psychopharmacological combined therapy" in Wien. Med. Wschr. 111, 1961, 307)].

1961 • 2 citations

[Dangers of a too rapid substitution of imipramine for an inhibitor of monoamine oxidase and of the nialamide-isoniazid-barbiturate combination at high doses in psychiatric therapy].

1967 • 2 citations

[On the clinical course and therapy of pathological conditions caused by incompatible antidepressants].

1968 • 1 citations