The role of micronutrient deficiency in carcinogenesis

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

BODY SIZE AND METABOLIC RATE

1947 • 1,709 citations

Can dietary beta-carotene materially reduce human cancer rates?

1981 • 1,575 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

Modern Nutrition in Health and Disease.

1981 • 851 citations

Cancer mortality for selected sites in 24 countries

1960 • 842 citations

Role of retinoids in differentiation and carcinogenesis.

1983 • 780 citations

Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence

1975 • 759 citations

Research on esophageal cancer in China: a review.

1980 • 672 citations

Colon Cancer and Dietary Fat, Phosphate, and Calcium: A Hypothesis

1984 • 547 citations

Single nutrients and immunity

1982 • 522 citations

Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N -Nitroso Compounds

1972 • 506 citations

Relevance of nitrosamines to human cancer

1984 • 489 citations

Effect of Added Dietary Calcium on Colonic Epithelial-Cell Proliferation in Subjects at High Risk for Familial Colonic Cancer

1985 • 479 citations

Toxicants Occurring Naturally in Foods

1973 • 461 citations

Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture.

1984 • 363 citations

Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine.

1981 • 346 citations

Inhibition of Chemical Carcinogenesis

1978 • 321 citations

N-Nitroso compounds: occurrence, biological effects and relevance to human cancer

1985 • 316 citations

Antitumor Activity of <i>β</i>-Carotene, Canthaxanthin and Phytoene

1982 • 311 citations

Inhibitors of Chemical Carcinogenesis

1978 • 304 citations

The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens

1984 • 296 citations

Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets

1983 • 258 citations

Nutrition and its Relationship to Cancer

1980 • 256 citations

Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium

1983 • 253 citations

FREE RADICAL BIOLOGY: XENOBIOTICS, CANCER, AND AGING*

1982 • 252 citations

Steady-state turnover and body pool of ascorbic acid in man

1979 • 240 citations

Epidemiologic and Dietary Evidence for a Specific Nutritional Predisposition to Esophageal Cancer

1981 • 233 citations

Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium

1984 • 225 citations

Proliferative patterns in colonic mucosa in familial polyposis

1975 • 221 citations

Effects of oleic and ricinoleic acids on net jejunal water and electrolyte movement. Perfusion studies in man.

1974 • 220 citations

Tumor Promotion by Dietary Fat in Azoxymethane-Induced Colon Carcinogenesis in Female F344 Rats: Influence of Amount and Source of Dietary Fat<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1984 • 220 citations

B-Complex Vitamins in Liver Disease of the Alcoholic

1965 • 215 citations

Overview of tumor promotion in animals

1983 • 206 citations

Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole.

1979 • 200 citations

Labile Methyl Groups and the Promotion of Cancer

1986 • 169 citations

Esophageal Cancer Among Black Men in Washington, D.C. II. Role of nutrition

1981 • 167 citations

Promotion of azoxymethane-induced intestinal cancer by high-fat diet in rats.

1979 • 164 citations

Perfusion of the Canine Colon with Unconjugated Bile Acids

1970 • 157 citations

Esophageal cancer among black men in Washington, D.C. I. Alcohol, tobacco, and other risk factors.

1981 • 157 citations

Diet and cancer of the esophagus

1981 • 156 citations

Zinc Deficiency and Methylbenzylnitrosamine-lnduced Esophageal Cancer in Rats1

1978 • 155 citations

Nutrition, Disease Resistance, and Immune Function

1984 • 143 citations

Induction of Mouse Lung Adenomas by Amines or Ureas Plus Nitrite and by N-Nitroso Compounds: Effect of Ascorbate, Gallic Acid, Thiocyanate, and Caffeine2

1975 • 136 citations

Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for esophageal cancer in Northern China: endogenous formation of nitrosoproline and its inhibition by vitamin C.

1986 • 136 citations

Etiological and preventive implications in alcohol carcinogenesis.

1979 • 134 citations

Oral Mucosal Carcinogenesis in Hamsters: Inhibition by Vitamin E<xref ref-type="fn" rid="fn2">2</xref>

1982 • 120 citations

Caffeic and ferulic acid as blockers of nitrosamine formation

1984 • 116 citations

Naturally Occurring Anticarcinogenic Substances in Foodstuffs

1985 • 114 citations

Nitrosamines and human cancer

1996 • 112 citations

Reaction of Nitrite With Ascorbate and Its Relation to Nitrosamine Formation2

1975 • 107 citations

Classification and risk assessment of individuals with familial polyposis, Gardner's syndrome, and familial non-polyposis colon cancer from [3H]thymidine labeling patterns in colonic epithelial cells.

1984 • 106 citations

Some Aspects of the Epidemiology and Etiology of Esophageal Cancer With Particular Emphasis on the Transkei, South Africa

1973 • 105 citations

PARTIAL PROTECTION OF RATS BY RIBOFLAVIN WITH CASEIN AGAINST LIVER CANCER CAUSED BY DIMETHYL-AMINOAZOBENZENE

1941 • 105 citations

The Dependence of the Genesis of Induced Skin Tumors on the Caloric Intake during Different Stages of Carcinogenesis

1944 • 101 citations

Hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.

1985 • 100 citations

Inhibition of mutagenicity of a model nitrosation reaction by naturally occurring phenolics, coffee and tea

1982 • 100 citations

Cell Renewal in Familial Polyposis: Comparison Between Polyps and Adjacent Healthy Mucosa

1972 • 100 citations

Epidemiology of cancer of the esophagus.

1984 • 99 citations

The Epidemiology of Diet and Cancer

1984 • 95 citations

THE REDUCTIVE CLEAVAGE OF 4-DIMETHYLAMINOAZOBENZENE BY RAT LIVER: REACTIVATION OF CARBON DIOXIDE-TREATED HOMOGENATES BY RIBOFLAVIN-ADENINE DINUCLEOTIDE

1950 • 94 citations

Choline Deficiency, Partial Hepatectomy, and Liver Tumors in Rats and Mice

1982 • 94 citations

Perfusion of Rabbit Colon with Ricinoleic Acid: Dose-Related Mucosal Injury, Fluid Secretion, and Increased Permeability

1977 • 94 citations

Regional variation of cancer mortality incidence and its relation to selenium levels in China

1985 • 93 citations

Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine

1984 • 86 citations

ASCORBIC ACID SYNTHESIS IN NORMAL AND DRUG-TREATED RATS, STUDIED WITH l-ASCORBIC-1-C14 ACID

1954 • 84 citations

Morphological and Functional Effects of Bile Salts on Rat Colon

1975 • 75 citations

LIVER CARCINOMA AND RELATED LESIONS IN CHRONIC CHOLINE DEFICIENCY

1954 • 68 citations

Dietary vitamin E intake and mammary carcinogenesis in rats

1982 • 67 citations

Monitoring N-nitrosamino acids excreted in the urine and feces of rats as an index for endogenous nitrosation

1982 • 67 citations

Clonal growth and serial propagation of rat esophageal epithelial cells

1983 • 65 citations

Are nutritionists worried about the epidemic of tumours in laboratory animals?

1981 • 64 citations

Nutrition in the 1980s: Constraints on Our Knowledge

1982 • 63 citations

Nutritional factors in the induction and maintenance of malignancy

1983 • 63 citations

Effect of Dioctyl Sodium Sulfosuccinate on Structure and Function of Rodent and Human Intestine

1975 • 60 citations

Lipotrope deficiency in experimental carcinogenesis

1980 • 60 citations

Inhibitory Effects of Molybdenum on Esophageal and Forestomach Carcinogenesis in Rats<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 58 citations

The possible role of riboflavin deficiency in epithelial neoplasia.I. epithelial changes of mice in simple deficiency

1965 • 57 citations

Faecal Urobilinogen Levels and pH of Stools in Population Groups with Different Incidence of Cancer of the Colon, and Their Possible Role in its Aetiology

1982 • 57 citations

Catalysis of nitrosation in vitro and in vivo in rats by catechin and resorcinol and inhibition by chlorogenic acid

1982 • 52 citations

Diet, faecal pH and colorectal cancer

1983 • 46 citations

Metabolic mechanisms of drug-nutrient interactions.

1985 • 45 citations

Proliferative liver lesions and sex steroids in rats

1982 • 45 citations

The epidemiology of cancer of the oesophagus

1978 • 44 citations

Nutritional factors and etiologic mechanisms in the causation of gastrointestinal cancers.

1982 • 41 citations

Effect of Deoxycholate on the Perfused Rat Colon

1982 • 40 citations

SUPPLEMENTARY FEEDING IN PREGNANCY

1944 • 39 citations

Esophageal microsomal metabolism of N-nitrosomethylbenzylamine in the zinc-deficient rat.

1984 • 34 citations

Mouse cell clones for improved quantitation of carcinogen-induced altered differentiation

1985 • 33 citations

The role of phenols in catalysis of nitrosamine formation

1982 • 33 citations

Bile acid heterogeneity and the gastrointestinal epithelium: from diarrhea to colon cancer.

1979 • 33 citations

Is Dietary β-Carotene an Anti-Cancer Agent?

2009 • 32 citations

Alterations of the aryl hydrocarbon hydroxylase system during riboflavin depletion and repletion

1974 • 31 citations

Alpha-tocopherol: uses in preventing nitrosamine formation.

1978 • 30 citations

Epithelial cell kinetics in the crypts of familial polyposis of colon

1977 • 30 citations

Economic botany in epidemiology

1978 • 29 citations

Multiple Congenital Abnormalities in the Rat Resulting from Acute Maternal Niacin Deficiency During Pregnancy.

1963 • 29 citations

Zinc and copper in human nutrition.

1981 • 29 citations

The Vulnerable Esophagus: Riboflavin Deficiency and Squamous Cell Dysplasia of the Skin and the Esophagus<xref ref-type="fn" rid="FN2">2</xref>

1984 • 27 citations

Zinc Deficiency and the Development of Esophageal and Forestomach Tumors in Sprague-Dawley Rats Fed Precursors of <italic>N</italic>-Nitroso-<italic>N</italic>-benzylmethylamine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1984 • 26 citations

Xenobiotic metabolism: Nutritional effects

1986 • 24 citations

Effect of dietary riboflavin on azo dye reductase in liver and in bacteria of cecal contents of rats

1970 • 23 citations

Transfer of sodium and water through isolated rat colonic mucosa under the influence of deoxycholate and oxyphenisatin

1977 • 23 citations

Inhibitory Effect of Sodium Ascorbate on Ethylurea and Sodium Nitrite Carcinogenesis and Negative Findings in Progeny After Intestinal Inoculation of Precursors Into Pregnant Hamsters2

1975 • 22 citations

Natural carcinogenic products

1979 • 20 citations

Effects of Various Dietary Staples on Esophageal Carcinogenesis Induced in Rats by Subcutaneously Administered &lt;italic&gt;N&lt;/italic&gt;-Nitrosomethylbenzylamine

1985 • 19 citations

Effects of butylated hydroxyanisole on the metabolism of benzo(a)pyrene by mouse lung microsomes.

1984 • 19 citations

Pathologic Changes Associated with Riboflavin Deficiency in the Mouse

1942 • 17 citations

Faecal pH value and its modification by dietary means in South African black and white school children

1979 • 14 citations

Alcohol and Vitamin Metabolism

1971 • 13 citations

Mutation, cancer and malformation

1985 • 13 citations

Esophageal Cancer Among Black Men in Washington, D.C. I. Alcohol, Tobacco, and Other Risk Factors

1981 • 11 citations

PRODUCTION OF CONGENITAL MALFORMATIONS BY DIETARY MEASURES

1958 • 10 citations

Experimental production of congenital deformities and their possible prevention in man

1963 • 10 citations

Effects of riboflavin deficiency on metabolism of nitrosamines by rat liver microsomes.

1985 • 10 citations

Esophageal Carcinoma: Field Studies and Laboratory Investigations

1984 • 6 citations

Modification of Carcinogenesis by Dietary and Nutritional Factors

1984 • 3 citations

[Effect of riboflavin deficiency and massive doses of vitamin C on carcinogenesis in the esophagus and liver in rats].

1985 • 3 citations

Correlations of values of micronutrients in sera with gastric pathology.

1985 • 3 citations

Assessment of endogenous nitrosation in humans in relation to the risk of cancer of the digestive tract.

1983 • 3 citations