Production, specificity, and functionality of monoclonal antibodies to specific peptide–major histocompatibility complex class II complexes formed by processing of exogenous protein

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

On the complexity of self

1991 • 261 citations

Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells

1991 • 250 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

Characterization and Quantitation of Peptide–MHC Complexes Produced from Hen Egg Lysozyme Using a Monoclonal Antibody

1997 • 169 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein

1997 • 135 citations

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

1997 • 131 citations

Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen–Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro

1997 • 128 citations

Monoclonal antibody detection of a major self peptide. MHC class II complex.

1992 • 127 citations

Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment.

1993 • 124 citations

Intracellular assembly and transport of endogenous peptide-MHC class II complexes

1994 • 111 citations

Specificity of the T cell receptor: two different determinants are generated by the same peptide and the I-Ak molecule.

1985 • 98 citations

Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen–Ia complex

1991 • 92 citations

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).

1996 • 77 citations

High-Efficiency Expression and Solubilization of Functional T Cell Antigen Receptor Heterodimers

1992 • 73 citations

A study of complexes of class II invariant chain peptide: Major histocompatibility complex class II molecules using a new complex‐specific monoclonal antibody

1996 • 62 citations

T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.

1995 • 58 citations

Epitope-specific enhancement of antigen presentation by invariant chain.

1993 • 52 citations

Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.

1991 • 52 citations

A three-domain T cell receptor is biologically active and specifically stains cell surface MHC/peptide complexes.

1997 • 52 citations

Studying interactions involving the T-cell antigen receptor by surface plasmon resonance

1996 • 43 citations

Lymphocyte homing: The scent of a follicle

1997 • 43 citations

Monoclonal antibodies directed against T cell epitopes presented by class I MHC antigens

1993 • 24 citations

Assembly of an abundant endogenous major histocompatibility complex class II/peptide complex in class II compartments

1997 • 21 citations

Modulation of the immune response in multiple sclerosis: production of monoclonal antibodies specific to HLA/myelin basic protein.

1997 • 18 citations

A method for producing monoclonal antibodies to human T-cell-receptor beta-chain variable regions.

1993 • 17 citations

Production of Rat × Mouse Hybridomas for the Study of the Nicotinic Acetylcholine Receptor

1985 • 7 citations