Two novel T cell epitope prediction algorithms based on MHC-binding motifs; comparison of predicted and published epitopes from Mycobacterium tuberculosis and HIV protein sequences

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Molecular analysis of the association of HLA-B53 and resistance to severe malaria

1992 • 645 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

A sequence pattern common to T cell epitopes.

1988 • 623 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.

1986 • 513 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes

1991 • 425 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

1988 • 417 citations

Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle

1992 • 414 citations

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1993 • 383 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.

1992 • 260 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

Identification of a motif for HLA-DR1 binding peptides using M13 display libraries.

1992 • 224 citations

Structure of peptides associated with MHC class I molecules

1994 • 200 citations

Identification of peptide sequences that potentially trigger HLA‐A2.1‐restricted cytotoxic T lymphocytes

1993 • 195 citations

Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling.

1993 • 164 citations

HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions.

1993 • 154 citations

Mapping of T cell epitopes using recombinant antigens and synthetic peptides.

1987 • 152 citations

HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs.

1993 • 143 citations

Six epitopes reacting with human cytotoxic CD8+ T cells in the central region of the HIV-1 NEF protein.

1991 • 138 citations

Mapping the fine specificity of a cytolytic T cell response to HIV-1 nef protein.

1990 • 133 citations

Strong conformational propensities enhance T cell antigenicity.

1987 • 130 citations

Amphipathic Helix

2012 • 119 citations

The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition.

1993 • 117 citations

Endogenous peptides bound to HLA-A3 possess a specific combination of anchor residues that permit identification of potential antigenic peptides.

1993 • 110 citations

Mapping of TH1 helper T-cell epitopes on major secreted mycobacterial antigen 85A in mice infected with live Mycobacterium bovis BCG

1994 • 108 citations

Primary in vivo responses to ovalbumin. Probing the predictive value of the Kb binding motif.

1993 • 107 citations

Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.

1992 • 105 citations

Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG

1988 • 101 citations

H-2Dd exploits a four residue peptide binding motif.

1993 • 98 citations

Broad recognition of cytotoxic T cell epitopes from the HIV-1 envelope protein with multiple class I histocompatibility molecules.

1992 • 97 citations

An HLA-A11-specific motif in nonamer peptides derived from viral and cellular proteins.

1993 • 96 citations

Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis.

1992 • 91 citations

Hydrophobic strip-of-helix algorithm for selection of T cell-presented peptides☆

1987 • 91 citations

T cell repertoire in tuberculosis: selective anergy to an immunodominant epitope of the 38‐kDa antigen in patients with active disease

1992 • 90 citations

Endogenous peptides with distinct amino acid anchor residue motifs bind to HLA-A1 and HLA-B8.

1994 • 85 citations

Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif.

1992 • 85 citations

Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase.

1992 • 81 citations

Truncation analysis of several DR binding epitopes.

1991 • 76 citations

Minute quantities of a single immunodominant foreign epitope are presented as large nested sets by major histocompatibility complex class II molecules

1993 • 73 citations

DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles.

1992 • 69 citations

AMycobacterium leprae-Specific Human T Cell Epitope Cross-Reactive with an HLA-DR2 Peptide

1988 • 67 citations

Identification of T cell stimulatory peptides from the 38-kDa protein of Mycobacterium tuberculosis.

1991 • 63 citations

Epitopes of the Mycobacterium tuberculosis 65-kilodalton protein antigen as recognized by human T cells.

1988 • 59 citations

Specific lysis of human immunodeficiency virus type 1-infected cells by a HLA-A3.1-restricted CD8+ cytotoxic T-lymphocyte clone that recognizes a conserved peptide sequence within the gp41 subunit of the envelope protein.

1991 • 55 citations

In vivo response of murine gamma delta T cells to a heat shock protein-derived peptide.

1993 • 55 citations

Peptides of 23 residues or greater are required to stimulate a high affinity class II‐restricted T cell response

1993 • 53 citations

Prediction and identification of an HLA‐DR‐restricted T cell determinant in the 19‐kDa protein of Mycobacteriurn tuberculosis

1988 • 51 citations

Definition of a DQ3.1-specific binding motif.

1994 • 44 citations

Genetically permissive recognition of adjacent epitopes from the 19-kDa antigen of Mycobacterium tuberculosis by human and murine T cells.

1993 • 41 citations

A novel approach to the generation of high affinity class II-binding peptides.

1990 • 41 citations

Comparison of structural requirements for interaction of the same peptide with I-Ek and I-Ed molecules in the activation of MHC class II-restricted T cells.

1991 • 40 citations

Sequence features that correlate with MHC restriction

1994 • 37 citations

Immunogenicity of the Human Immunodeficiency Virus (HIV) RecombinantnefGene Product. Mapping of T-Cell and B-Cell Epitopes in Immunized Chimpanzees

1990 • 36 citations

Naturally processed HLA class I bound peptides from c-myc-transfected cells reveal allele-specific motifs.

1993 • 31 citations

Human Immunodeficiency Virus Reverse Transcriptase T Helper Epitopes Identified in Mice and Humans: Correlation with a Cytotoxic T Cell Epitope

1991 • 30 citations

Mapping of T helper cell epitopes by using peptides spanning the 19-kDa protein of Mycobacterium tuberculosis. Evidence for unique and shared epitopes in the stimulation of antibody and delayed-type hypersensitivity responses.

1992 • 29 citations

Prediction of an HLA B8-restricted influenza epitope by motif.

1993 • 28 citations

A pattern search method for putative anchor residues in T cell epitopes

1993 • 24 citations

Immunization with soluble protein-pulsed spleen cells induces class I-restricted cytotoxic T lymphocytes that recognize immunodominant epitopic peptides from Plasmodium falciparum and HIV-1.

1992 • 22 citations

Recognition of peptide epitopes of the 16,000 MW antigen of Mycobacterium tuberculosis by murine T cells.

1993 • 21 citations

Identification of B- and T-cell epitopes within the MTP40 protein of Mycobacterium tuberculosis and their correlation with the disease course

1991 • 21 citations

Can one predict antigenic peptides for MHC class I-restricted cytotoxic T lymphocytes useful for vaccination?

1993 • 16 citations

Random association between the peptide repertoire of A2.1 class I and several different DR class II molecules.

1991 • 15 citations

The effect of lipoylation on CD4 T-cell recognition of the 19,000 MW Mycobacterium tuberculosis antigen.

1993 • 14 citations

Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria.

1990 • 12 citations

Lymphocyte responses to DR4/1‐restricted peptides in rheumatoid arthritis. The immunodominant T cell epitope on the 19‐kd mycobacterium tuberculosis protein

1992 • 8 citations

Comparison of actual and random-positioning-model distributions of peptide scavenging and T cell-presented sites in antigenic proteins

1993 • 1 citations