The "kynurenate test", a biochemical assay for putative cognition enhancers.

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

Neuropharmacology of quinolinic and kynurenic acids.

1993 • 920 citations

D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.

1995 • 823 citations

Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

1990 • 806 citations

A Glycine Site Associated with N‐Methyl‐<scp>d</scp>‐Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists

1989 • 723 citations

A Double-Blind, Placebo-Controlled Multicenter Study of Tacrine for Alzheimer's Disease

1992 • 618 citations

Involvement of Hormonal and Neuromodulatory Systems in the Regulation of Memory Storage

1989 • 565 citations

Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

1988 • 495 citations

Disease‐specific patterns of locus coeruleus cell loss

1992 • 493 citations

A simple apparatus for studying the release of neurotransmitters from synaptosomes

1974 • 456 citations

The presence of free D‐serine in rat brain

1992 • 448 citations

The glycine site of the NMDA receptor — five years on

1993 • 440 citations

Neuronal Nicotinic Acetylcholine Receptors

1996 • 377 citations

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

1990 • 303 citations

d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics

1989 • 302 citations

Presence of Kynurenic Acid in the Mammalian Brain

1988 • 273 citations

Release of [³H]‐noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [³H]‐dopamine release

1996 • 263 citations

Embryonic Development and Postnatal Changes in Free <scp>d</scp>‐Aspartate and <scp>d</scp>‐Serine in the Human Prefrontal Cortex

1993 • 252 citations

Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB

1993 • 224 citations

Identification and quantification of kynurenic acid in human brain tissue

1988 • 217 citations

Multiple GABAB receptors

1993 • 217 citations

Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus.

1991 • 213 citations

Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB Antagonists

1995 • 201 citations

Modulation of Both the Early and the Late Phase of Mossy Fiber LTP by the Activation of β-Adrenergic Receptors

1996 • 197 citations

Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices

1982 • 157 citations

(+)‐Anatoxin‐a Is a Potent Agonist at Neuronal Nicotinic Acetylcholine Receptors

1993 • 131 citations

Noradrenergic and locus coeruleus modulation of the perforant path-evoked potential in rat dentate gyrus supports a role for the locus coeruleus in attentional and memorial processes

1991 • 128 citations

Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.

1987 • 125 citations

Release-enhancing glycine-dependent presynaptic NMDA receptors exist on noradrenergic terminals of hippocampus

1990 • 121 citations

CGP 36742: The first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys

1993 • 119 citations

Taking stock of cognition enhancers

1991 • 116 citations

Ethanol inhibits N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat cortical slices.

1990 • 113 citations

Kynurenic acid is present in the rat brain and its content increases during development and aging processes

1988 • 113 citations

Is there a functional linkage between neurotransmitter uptake mechanisms and presynaptic receptors?

1984 • 112 citations

Characterization df a [³H]Glycine Recognition Site as a Modulatory Site of the N‐Methyl‐D‐Aspartate Receptor Complex

1989 • 106 citations

N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. I. Location on axon terminals and pharmacological characterization.

1992 • 101 citations

Age-related changes in kynurenic acid production in rat brain

1992 • 94 citations

The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro

1993 • 92 citations

Effects of NMDA Modulation in Scopolamine Dementiaa

1991 • 87 citations

Alterations in the locus coeruleus in dementias of Alzheimer's and Parkinson's disease

1991 • 83 citations

DuP 996 (3,3‐bis(4‐pyrindinylmethyl)‐1‐phenylindolin‐2‐one) enhances the stimulus‐induced release of acetylcholine from rat brain in vitro and in vivo

1990 • 82 citations

Memory processing by the limbic system: Role of specific neurotransmitter systems

1993 • 77 citations

Baclofen disrupts passive avoidance retention in rats

1987 • 69 citations

Nootropic drugs and brain cholinergic mechanisms

1989 • 64 citations

Nicotinic Autoreceptors Mediating Enhancement of Acetylcholine Release Become Operative in Conditions of “Impaired” Cholinergic Presynaptic Function

1996 • 61 citations

NMDA-induced hippocampal [3H]norepinephrine release is modulated by glycine

1988 • 58 citations

Effects of nicotinic agonists and antagonists on N‐methyl‐D‐aspartate‐induced ³H‐norepinephrine release and ³H‐(1‐[1‐(2‐thienyl)cyclohexyl]‐piperidine) binding in rat hippocampus

1989 • 58 citations

Stimulation of noradrenaline release in human cerebral cortex mediated by N‐methyl‐<scp>d</scp>‐aspartate (NMDA) and non‐NMDA receptors

1992 • 53 citations

[³H]Norepinephrine Release from Hippocampal Slices Is an In Vitro Biochemical Tool for Investigating the Pharmacological Properties of Excitatory Amino Acid Receptors

1987 • 51 citations

Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission

1994 • 47 citations

Putative cognition enhancers reverse kynurenic acid antagonism at hippocampal NMDA receptors

1995 • 26 citations

Cortical norepinephrine release elicited in situ by N-methyl-d-aspartate (NMDA) receptor stimulation: a microdialysis study

1992 • 25 citations

AMPA Receptor Antagonists: Potential Therapeutic Applications

2006 • 19 citations

CR 2249: a New Putative Memory Enhancer. Behavioural Studies on Learning and Memory in Rats and Mice

1996 • 18 citations

Unique properties of norepinephrine release from terminals arising from the locus coeruleus: high potassium sensitivity and lack of linopirdine (DuP 996) enhancement

1993 • 13 citations

Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex

1997 • 7 citations

Effects of putative cognition enhancers on the NMDA receptor by [3H]MK801 binding

1995 • 7 citations