Cytochrome P450 in Human Fetal Liver: Significance and Fetal-Specific Expresson

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

1986 • 408 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.

1989 • 303 citations

Characterization of Human Microsomal Cytochrome P-450 Enzymes

1989 • 244 citations

Human Dioxin-Inducible Cytochrome P ₁ -450: Complementary DNA and Amino Acid Sequence

1985 • 233 citations

Fetus-specific expression of a form of cytochrome P-450 in human livers

1990 • 205 citations

Metabolic activation of mutagenic heterocylic aromatic amines from protein pyrolysates

1986 • 187 citations

Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.

1990 • 185 citations

Human P450PCN1: Sequence, Chromosome Localization, and Direct Evidence through cDNA Expression That P450PCN1 Is Nifedipine Oxidase

1988 • 164 citations

P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate.

1987 • 160 citations

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

1986 • 158 citations

The presence of a monooxygenase system in human fetal liver microsomes

1970 • 145 citations

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

1986 • 142 citations

Purification and properties of cytochrome P-450 from homogenates of human fetal livers

1985 • 137 citations

Molecular Cloning and Sequence Analysis of cDNA Containing the Entire Coding Region for Human Fetal Liver Cytochrome P-4501

1989 • 118 citations

Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.

1986 • 110 citations

Drug Metabolism by the Human Fetus

1980 • 102 citations

Reactions Catalyzed by the Cytochrome P-450 System

1980 • 95 citations

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1987 • 91 citations

Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations

1987 • 83 citations

Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family

1989 • 81 citations

Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity

1989 • 72 citations

Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.

1987 • 71 citations

Metabolic activation of aflatoxin B1 and 2-amino-3-methylimidazo[4,5-f]-quinoline by human adult and fetal livers.

1990 • 55 citations

Metabolism of ethylmorphine and aniline in human fetal liver

1972 • 55 citations

Four Forms of Cytochrome P‐450 in Human Fetal Liver: Purification and Their Capacity to Activate Promutagens

1991 • 54 citations

Hydroxylation of 3,4-benzpyrene in human fetal tissue homogenates

1972 • 53 citations

Drugs and fetal metabolism

1973 • 52 citations

Properties of hydroxylase systems in the human fetal liver active on free and sulfoconjugated steroids

1975 • 51 citations

Cytochrome P450IA expression in adult and fetal human liver

1992 • 49 citations

Drug metabolism in human fetal tissues

1973 • 48 citations

Metabolism of Chlorpromazine and p‐Nitrobenzoic Acid in the Liver, Intestine and Kidney of the Human Foetus

1971 • 46 citations

Metabolic Activation of Pyrolysate Arylamines by Human Liver Microsomes; Possible Involvement of a P‐448‐H Type Cytochrome P‐450

1988 • 44 citations

Human fetal and adult liver metabolism of ethylmorphine

1989 • 44 citations

Partial purification and properties of cytochrome P450 from homogenates of human fetal livers

1979 • 36 citations

Immunochemical examinations of cytochrome P-450 in various tissues of human fetuses using antibodies to human fetal cytochrome P-450, P-450 HFLa

1985 • 33 citations

Mutagenic activation of aflatoxin B1 by P-450 HFLa in human fetal livers

1989 • 33 citations

Diazepam metabolism in human foetal and adult liver

1977 • 31 citations

Stable expression of cytochrome P450IIIA7 cDNA in human breast cancer cell line MCF-7 and its application to cytotoxicity testing

1992 • 29 citations

Aryl hydrocarbon hydroxylase activity and microsomal cytochrome content of human fetal tissues.

1978 • 27 citations

Components of the heme biosynthetic pathway and mixed function oxidase activity in human fetal tissues

1975 • 25 citations

Immunochemical similarity of P-450 HFLa, a form of cytochrome P-450 in human fetal livers, to a form of rat liver cytochrome P-450 inducible by macrolide antibiotics

1988 • 24 citations

Immunochemical characterization and toxcological significance of P-450HFLb purified from human fetal livers

1992 • 24 citations

Interspecies homology of cytochrome P-450: toxicological significance of cytochrome P-450 cross-reactive with anti-rat P-448-H antibodies in liver microsomes from dogs, monkeys and humans

1989 • 13 citations

Metabolism of Desmethylimipramine in Human Foetal and Adult Liver Microsomes

1974 • 11 citations

METABOLISM OF PREGNENOLONE AND PREGNENOLONE SULPHATE IN HUMAN FOETAL LIVER TISSUE IN VITRO

1974 • 10 citations

A new form of cytochrome P-450 responsible for mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline in human livers.

1992 • 5 citations

Deleted Work

1955 • 0 citations

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