A review of theoretical aspects of HLA and disease associations

Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease

1959 • 14,850 citations

THE GENETIC BASIS OF EVOLUTIONARY CHANGE

1975 • 3,588 citations

The hitch-hiking effect of a favourable gene

1974 • 3,276 citations

The hitch-hiking effect of a favourable gene

2007 • 2,840 citations

ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASE

1955 • 2,755 citations

Histocompatibility Testing

1971 • 1,937 citations

Discrete Multivariate Analysis

1977 • 1,841 citations

Epidemiology: Principles and Methods

1970 • 1,500 citations

Statistical Methods for Rates and Proportions.

1973 • 1,326 citations

Discrete Multivariate Analysis.

1976 • 1,321 citations

Statistical methods in medical research

1972 • 1,303 citations

HISTOCOMPATIBILITY TESTING, 1972

1974 • 1,267 citations

Biology of the Mouse Histocompatibility-2 Complex

1975 • 1,145 citations

Histocompatibility Testing 1965

1966 • 1,036 citations

THE ESTIMATION AND SIGNIFICANCE OF THE LOGARITHM OF A RATIO OF FREQUENCIES

1956 • 1,026 citations

BONE-MARROW TRANSPLANTATION IN A PATIENT WITH THE WISKOTT-ALDRICH SYNDROME

1968 • 873 citations

Statistical Methods for Rates and Proportions

1974 • 555 citations

HL‐A Antigens and Disease Statistical and Genetical Considerations

1974 • 524 citations

Evolutionary Significance of the HL-A System

1972 • 523 citations

HL-A, IMMUNE-RESPONSE GENES, AND DISEASE

1974 • 449 citations

GENETIC CONTROL OF THE ANTIBODY RESPONSE

1965 • 405 citations

Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.

1976 • 396 citations

Arthritis and Allied Conditions.

1979 • 395 citations

Idiopathic Hemochromatosis

1977 • 355 citations

GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKÆMOGENESIS

1964 • 350 citations

Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.

1975 • 290 citations

HL‐A and Disease Associations ‐ A Survey

1975 • 280 citations

The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus

1967 • 280 citations

THE DETECTION OF AUTOSOMAL LINKAGE IN DATA WHICH CONSIST OF PAIRS OF BROTHERS AND SISTERS OF UNSPECIFIED PARENTAGE

1935 • 271 citations

Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease.

1978 • 269 citations

Measuring the strength of associations between HLA antigens and diseases

1981 • 239 citations

HLA-DW3 ASSOCIATED WITH CŒLIAC DISEASE

1976 • 235 citations

EVOLUTION AND FUNCTION OF THE HLA SYSTEM

1978 • 234 citations

STUDIES ON ARTIFICIAL ANTIGENS

1963 • 219 citations

Histocompatibility antigens, immune responsiveness and susceptibility to disease

1972 • 210 citations

THE EFFECT OF A SELECTED LOCUS ON LINKED NEUTRAL LOCI

1977 • 208 citations

The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus

1967 • 205 citations

Evidence for a specific B27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis

1979 • 179 citations

STUDIES ON ARTIFICIAL ANTIGENS

1963 • 179 citations

GENETIC CONTROL OF THE ANTIBODY RESPONSE

1967 • 178 citations

Disease Susceptibility Genes ‐ their Identification by Multiple Case Family Studies

1976 • 155 citations

Sibling Method for Detecting HLA‐Linked Genes in Disease

1977 • 150 citations

Measuring Selection in Natural Populations

1977 • 127 citations

Heterogeneity in Diabetes Mellitus—Update, 1978: Evidence for Further Genetic Heterogeneity within Juvenile-onset Insulin-dependent Diabetes Mellitus

1978 • 124 citations

Gene dosage and susceptibility to insulin‐dependent diabetes

1980 • 117 citations

The Affected Sib Pair IBD Distribution for HLA‐Linked Disease Susceptibility Genes

1978 • 114 citations

Genetic linkage between hereditary hemochromatosis and HLA.

1979 • 107 citations

Genetic basis of gluten-sensitive enteropathy

1978 • 97 citations

A two locus model for juvenile diabetes

1980 • 97 citations

Hyperpyruvaturia following intravenous administration of fructose.

1958 • 96 citations

Immunogenetic Aspects of Nasopharyngeal Carcinoma. IV. Increased Risk in Chinese of Nasopharyngeal Carcinoma Associated With a Chinese-Related HLA Profile (A2, Singapore 2)2

1976 • 94 citations

Heredity of idiopathic haemochromatosis: A study of 106 families

1977 • 92 citations

The effect of selected linked locus on heterozygosity of neutral alleles (the hitch-hiking effect)

1975 • 86 citations

Population Genetics and Ecology.

1977 • 85 citations

HLA family studies and multiple sclerosis: A common gene, dominantly expressed

1981 • 82 citations

Immunogenetics and Immunodeficiency

1976 • 80 citations

The Genetics of Coeliac Disease

1981 • 79 citations

Juvenile-onset Diabetes: HLA-A, -B, -C, and -DR Alloantigens

1978 • 76 citations

HISTOCOMPATIBILITY ANTIGENS AS MARKERS OF ABNORMAL IRON METABOLISM IN PATIENTS WITH IDIOPATHIC HÆMOCHROMATOSIS AND THEIR RELATIVES

1977 • 75 citations

A three‐allele model for heterogeneity of juvenile onset insulin‐dependent diabetes

1980 • 71 citations

HEMOCHROMATOSE IDIOPATHIQUE. MALADIE ASSOCIEE A L'ANTIGENE TISSULAIRE HL-A3.

1975 • 68 citations

Studies on African Pygmies. IV. A comparative study of the HL-A polymorphism in the Babinga Pygmies and other African and Caucasian populations.

1970 • 64 citations

The HLA System: Introduction

1978 • 61 citations

HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees.

1980 • 58 citations

Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs.

1981 • 57 citations

Heterogeneity in diabetes mellitus--update, 1978. Evidence for further genetic heterogeneity within juvenile-onset insulin-dependent diabetes mellitus

1978 • 57 citations

Some epistatic two-locus models of disease. II. The confounding of linkage and association.

1981 • 55 citations

SURVIVAL PROCESS OF LINKED MUTANT GENES

1967 • 54 citations

Analysis of linkage between the major histocompatibility system and juvenile, insulin-dependent diabetes in multiplex families. Reanalysis of data.

1978 • 53 citations

Juvenile-onset diabetes HLA-A, -B, -C, and -DR alloantigens

1979 • 46 citations

Diabetes Mellitus in Identical Twins

1976 • 45 citations

SIMPLE ESTIMATION OF POPULATION ATTRIBUTABLE RISK FROM CASE-CONTROL STUDIES

1977 • 42 citations

The Search for a Human Equivalent of the Mouse T‐Locus ‐ Negative Results from a Study of HL—A Types in Spina Bifida

1975 • 41 citations

The association between the HLA system and disease.

1977 • 39 citations

The HLA System and Disease

1981 • 37 citations

Association of HLA-A3 and HLA-B14 antigens with idiopathic hemochromatosis

1978 • 35 citations

Is Juvenile Diabetes Determined by a Single Gene Closely Linked to HLA?

1979 • 35 citations

HLA Haplotype Associations with Disease

1979 • 32 citations

Genetics of HLA: the major human histocompatibility system

1978 • 32 citations

HLA: a super supergene.

1978 • 28 citations

Ethnic variation in genetic disease: possible roles of hitchhiking and epistasis.

1975 • 28 citations

Statistical methods for assessing linkage disequilibrium at the HLA-A, B, C loci

1981 • 27 citations

Tenth Symposium on Advanced Medicine

1975 • 25 citations

Survival Process of Linked Mutant Genes

1967 • 22 citations

The HL-A System as a Model for Studying the Interaction between Selection, Migration, and Linkage

1976 • 22 citations

Inheritance of susceptibility to juvenile onset diabetes.

1979 • 18 citations

Estimating the Parameters of the Incompletely Penetrant Single Locus Model Using Multiple Populations

1977 • 17 citations

The Major Histocompatibility Complexes

1975 • 17 citations

Detection of HLA Haplotype Associations with Disease

1980 • 15 citations

The effect of association of genetic factors on relative risk

1980 • 15 citations

Evolution of HL-A and other major histocompatibility systems.

1975 • 13 citations

HLA Studies in Diabetics

1979 • 11 citations

Is juvenile diabetes determined by a single gene closely linked to HLA?

1979 • 9 citations

HL-A antigens in clinical medicine

1976 • 9 citations

A Note on Relative Risks*

1977 • 9 citations

Statistical analysis of HLA-disease associations.

1979 • 8 citations

Investigations of a Two-Locus Model for Coeliac Disease

1981 • 3 citations