T‐Helper‐Cell Determinants in Protein Antigens are Preferentially Located in Cysteine‐Rich Antigen Segments Resistant to Proteolytic Cleavage by Cathepsin B, L, and D

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

A sequence pattern common to T cell epitopes.

1988 • 623 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

Progress in Clinical and Biological Research

1984 • 554 citations

Amphiphilic Secondary Structure: Design of Peptide Hormones

1984 • 541 citations

T-cell antigenic sites tend to be amphipathic structures.

1985 • 527 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

A Chemical Approach to Protein Design—Template‐Assembled Synthetic Proteins (TASP)

1989 • 403 citations

Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes.

1981 • 391 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

Design of a 4-helix bundle protein: synthesis of peptides which self-associate into a helical protein

1987 • 282 citations

Identification of proteases that process distinct epitopes on the same protein.

1989 • 147 citations

Strong conformational propensities enhance T cell antigenicity.

1987 • 130 citations

Cellular interactions in the immune response

1972 • 122 citations

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A.alpha., and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates

1984 • 91 citations

Human leukocyte cathepsin G. Subsite mapping with 4-nitroanilides, chemical modification, and effect of possible cofactors

1985 • 88 citations

Analysis of the code relating sequence to conformation in globular proteins. Theory and application of expected information

1974 • 85 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors

1989 • 84 citations

A group-specific inhibitor of lysosomal cysteine proteinases selectively inhibits both proteolytic degradation and presentation of the antigen dinitrophenyl-poly-L-lysine by guinea pig accessory cells to T cells.

1986 • 74 citations

The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity

1986 • 66 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors.

1988 • 61 citations

Avian Retroviral Protease and Cellular Aspartic Proteases are Distinguished by Activities on Peptide Substrates

1989 • 61 citations

Analysis of the code relating sequence to conformation in globular proteins. Development of a stereochemical alphabet on the basis of intra-residue information

1974 • 43 citations

Short model peptides having a high α‐helical tendency: Design and solution properties

1989 • 33 citations

Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver

1987 • 32 citations

Use of New Synthetic Substrates for Assays of Cathepsin L and Cathepsin B1

1983 • 32 citations

Rat brain cathepsin L: Characterization and differentiation from cathepsin B utilizing opioid peptides

1987 • 28 citations

Substrate specificity of cerebral cathepsin D and high‐Mr aspartic endopeptidase

1988 • 8 citations

The kinetics of hydrolysis of some synthetic substrates containing neutral hydrophilic groups by pig pepsin and chicken liver cathepsin D.

1983 • 6 citations

Are Z-Arg-Gly-Phe-Phe-Leu-MNA and Z-Arg-Gly-Phe-Phe-Pro-MNA suitable substrates for the demonstration of cathepsin D activity?

1988 • 6 citations

Amino acids and peptides. XXII. Synthesis of substrates and inhibitors of human leukocyte cathepsin G.

1988 • 3 citations