Mass spectrometry in the search for uremic toxins

Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes

1997 • 457 citations

Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis.

1994 • 402 citations

Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure

1994 • 374 citations

Oxford Textbook of Clinical Nephrology

1992 • 367 citations

Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure

1997 • 251 citations

Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients.

1997 • 190 citations

Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography.

1988 • 182 citations

Hyperhomocysteinemia and the risk for vascular disease in hemodialysis patients.

1995 • 173 citations

Progression of Glomerular Sclerosis in Experimental Uremic Rats by Administration of Indole, a Precursor of Indoxyl Sulfate

1994 • 171 citations

Mechanisms of uremic inhibition of phagocyte reactive species production: Characterization of the role of p-cresol

1995 • 148 citations

Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients

1997 • 129 citations

A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia.

1993 • 105 citations

Metabolic profiling with gas chromatography—mass spectrometry and its application to clinical medicine

1986 • 98 citations

Efficient Removal of Albumin-Bound Furancarboxylic Acid, an Inhibitor of Erythropoiesis, by Continuous Ambulatory Peritoneal Dialysis

1990 • 95 citations

Endogenous accumulation products and serum protein binding in uremia.

1981 • 88 citations

Carbamylation-induced alterations in low-density lipoprotein metabolism

1992 • 88 citations

Oral Sorbent Suppresses Accumulation of Albumin-Bound Indoxyl Sulphate in Serum of Haemodialysis Patients

1991 • 87 citations

Nutritional Management of Renal Disease

2021 • 83 citations

Modification of β2m with advanced glycation end products as observed in dialysis-related amyloidosis by 3-DG accumulating in uremic serum

1996 • 82 citations

Trennung und charakterisierung saurer harnbestandteile

1979 • 78 citations

Decreased drug binding in uraemia: Effect of indoxyl sulphate and other endogenous substances on the binding of drugs and dyes to human albumin

1982 • 75 citations

Inhibitory Effect of Oral Sorbent on Accumulation of Albumin-Bound Indoxyl Sulfate in Serum of Experimental Uremic Rats

1991 • 73 citations

Phenol and p-cresol accumulated in uremic serum measured by HPLC with fluorescence detection

1993 • 72 citations

[Separation and characterization of acidic urine constituents (author's transl)].

1979 • 70 citations

A gas chromatographic-mass spectrometric analysis for phenols in uremic serum

1981 • 69 citations

Gas chromatographic—mass spectrometric analysis of polyols in urine and serum of uremic patients

1983 • 67 citations

Amyloid β2-microglobulin is modified with Nε-(carboxymethyl)lysine in dialysis-related amyloidosis

1996 • 66 citations

Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure.

1995 • 64 citations

Decreased clearance of uraemic and mildly carbamylated low‐density lipoprotein

1994 • 64 citations

Presence of 3-Deoxyglucosone, a Potent Protein Crosslinking Intermediate of Maillard Reaction, in Diabetic Serum

1993 • 62 citations

Suppressive Effect of an Oral Sorbent on the Accumulation of <i>p</i>-Cresol in the Serum of Experimental Uremic Rats

1993 • 62 citations

Amyloid β2-microglobulin is modified with imidazolone, a novel advanced glycation end product, in dialysis-related amyloidosis

1997 • 61 citations

Induction of chromosome banding by trypsin/EDTA for gene mapping by in situ hybridization

1985 • 59 citations

Accumulation of furancarboxylic acids in uremic serum as inhibitors of drug binding

1988 • 59 citations

Imidazolone, a novel advanced glycation end product, is present at high levels in kidneys of rats with streptozotocin‐induced diabetes

1997 • 55 citations

Uremic Toxins and the Elusive Middle Molecules

1984 • 55 citations

Elevated Serum Levels of 3-Deoxyglucosone, a Potent Protein-Cross-Linking Intermediate of the Maillard Reaction, in Uremic Patients

1995 • 53 citations

Gas chromatographic and gas chromatographic—mass spectrometric analysis of organic acids in plasma of patients with chronic renal failure

1984 • 53 citations

Beta-Amyloid Deposition in the Medial Temporal Lobe in Elderly Non-Demented Brains and in Alzheimer’s Disease

1995 • 50 citations

Isolation and chemical identification of inhibitors of plasma ligand binding

1986 • 49 citations

Determination of polyols in serum by selected ion monitoring.

1984 • 47 citations

Accumulation of Indoxyl-β-<i>D</i>-Glucuronide in Uremic Serum: Suppression of Its Production by Oral Sorbent and Efficient Removal by Hemodialysis

1996 • 47 citations

Isolation and Characterization of an Endogenous Drug-Binding Inhibitor Present in Uremic Serum

1986 • 46 citations

Isolation and chemical characterization of 2-hydroxybenzoylglycine as a drug binding inhibitor in uremia.

1983 • 45 citations

Volatile substances in blood serum: Profile analysis and quantitative determination

1977 • 45 citations

Quantification of serum 1,5-anhydroglucitol in uremic and diabetic patients by liquid chromatography/mass spectrometry

1994 • 44 citations

Pattern of aliphatic dicarboxylic acids in uremic serum including a new organic acid, 2,4-dimethyladipic acid

1979 • 44 citations

Determination of polyols in serum by selected ion monitoring.

1984 • 43 citations

Analysis of polyols in uremic serum by liquid chromatography combined with atmospheric pressure chemical ionization mass spectrometry

1993 • 42 citations

Screening of UV-absorbing solutes in uremic serum by reversed phase HPLC — Change of blood levels in different therapies

1985 • 40 citations

Inhibition of mitochondrial respiration by furancarboxylic acid accumulated in uremic serum in its albumin-bound and non-dialyzable form.

1993 • 40 citations

Urea-derived cyanate forms epsilon-amino-carbamoyl-lysine (homocitrulline) in leukocyte proteins in patients with end-stage renal disease on peritoneal dialysis.

1994 • 40 citations

Inhibition of Hepatic Glutathione S-Transferases by a Major Endogenous Ligand Substance Present in Uremic Serum

1988 • 37 citations

Inhibition of Glucose Utilization in Isolated Rat Soleus Muscle by Pseudouridine: Implications for Renal Failure

1993 • 33 citations

Dialysis-associated encephalopathy: light and electron microscopic morphology and topography with evidence of aluminum by laser microprobe mass analysis

1993 • 32 citations

Characterization of a double conjugate in uremic body fluids

1981 • 31 citations

Profiling of Endogenous Ligand Solutes That Bind to Serum Proteins in Sera of Patients with Uremia

1986 • 30 citations

A gas chromatographic-mass spectrometric assay for nine hydroxyphenolic acids in uremic serum

1979 • 30 citations

P-Cresol, a uremic compound, enhances the uptake of aluminum in hepatocytes.

1997 • 29 citations

Gas chromatographic mass spectrometric computer analysis of volatile components in blood plasma from hemodialysis patients

1975 • 29 citations

Profiling of uremic serum by high-resolution gas chromatography—electron-impact, chemical ionization mass spectrometry

1979 • 29 citations

The determination of oxalate in haemodialysate and plasma: A means to detect and study ‘hyperoxaluria’ in haemodialysed patients

1986 • 29 citations

Detection and Quantitation of β-2-Microglobulin Glycosylated End Products in Human Serum by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

1996 • 27 citations

Profiling of uremic ultrafiltrate using high resolution gas chromatography-mass spectrometry — identification of 6 polyphenols

1980 • 26 citations

Glutathione adducts, not carbamylated lysines, are the major modification of lens α-crystallins from renal failure patients

1995 • 26 citations

Primary hyperoxaluria in an adult with renal failure, livedo reticularis, retinopathy, and peripheral neuropathy

1997 • 24 citations

Determination of Urea Kinetics by Isotope Dilution with [13C]Urea and Gas Chromatography–isotope Ratio Mass Spectrometry (GC–IRMS) Analysis

1997 • 23 citations

Identification by nuclear magnetic resonance and mass spectrometry of a glucuronic acid conjugate of o-hydroxybenzoic acid in normal urine and uremic plasma.

1985 • 23 citations

Identification and quantification of a protein-bound ligand in uremic serum.

1987 • 23 citations

Liquid-chromatographic profiling of solutes in serum of uremic patients undergoing hemodialysis and chronic ambulatory peritoneal dialysis (CAPD); high concentrations of pseudouridine in CAPD patients.

1988 • 23 citations

Accumulation of quinolinic acid in uremic serum and its removal by hemodialysis

1991 • 22 citations

Rapid assay for indoxyl sulphate in uremic serum by internal-surface reversed-phase high-performance liquid chromatography

1988 • 21 citations

HPLC fractions of human uremic plasma inhibit the RBC membrane calcium pump

1997 • 20 citations

A naturally occurring furan fatty acid enhances drug inhibition of thyroxine binding in serum

1993 • 20 citations

Liquid-chromatographic profiling of solutes in serum of uremic patients undergoing hemodialysis and chronic ambulatory peritoneal dialysis (CAPD); high concentrations of pseudouridine in CAPD patients.

1988 • 20 citations

Creatol, a Creatinine Metabolite, as a Useful Determinant of Renal Function

1994 • 20 citations

Ultrasensitive analysis of the intestinal absorption and compartmentalization of aluminium in uraemic rats: a 26Al tracer study employing accelerator mass spectrometry

1997 • 17 citations

A new glycine containing compound with a blocked amino group from uremic body fluids.

1980 • 17 citations

Isolation of haemorphin-related peptides from filter membranes collected in connection with haemofiltration of human subjects

1996 • 16 citations

Contribution of dialysis to endogenous oxalate production in patients with chronic renal failure

1994 • 14 citations

Hexachlorobenzene and 1, 1-di(4-Chlorophenyl)-2,2-Dichloroethene in Serum of Uremic Patients and Healthy Persons: Determination by Capillary Gas Chromatography and Electron Capture Detection

1988 • 14 citations

Profiling of organic acids and polyols in nerves of uraemic and non-uraemic patients

1986 • 14 citations

Interleukin 8 and Biocompatibility of Dialysis Membranes

1995 • 13 citations

Dialysis-Associated Arthropathy: Secondary Ion Mass Spectrometry Evidence of Aluminum Silicate in <i>β</i><sub>2</sub>-MicroglobuIin Amyloid Synovial Tissue and Articular Cartilage

1993 • 13 citations

Identification of 6-deoxyallitol and 6-deoxygulitol in human urine

1984 • 12 citations

High-resolution gas chromatography-mass spectrometry of the methyl esters of organic acids from uremic hemofiltrates

1981 • 12 citations

Clean-up by high-performance liquid chromatography of polychlorodibenzo-p-dioxins and polychlorodibenzofurans on a pyrenylethylsilica gel column

1994 • 12 citations

Tyrosine and N-carbamoyl-tyrosine in end-stage renal disease during continuous ambulatory peritoneal dialysis.

1991 • 11 citations

Myoinositol Inhibits Proliferation of Cultured Schwann Cells: Evidence for Neurotoxicity of Myoinositol

1989 • 11 citations

A method for separation of middle molecules by high performance liquid chromatography: application in studies of glucuronyl-o-hydroxyhippurate in normal and uremic subjects.

1986 • 10 citations

Cardiovascular Effects of Chronic Naloxone Infusion in Normal Dogs

1986 • 9 citations

Beta-2-microglobulin: A Possible New Uremic Toxin?

1988 • 8 citations

Detection of ribose-methylated nucleotides in Pyrodictium occultum tRNA by liquid chromatography—frit-fast atom bombardment mass spectrometry

1994 • 8 citations

On Drug Artifacts in Middle Molecule Analysis

1985 • 8 citations

Structural characterization of modified nucleosides in tRNA hydrolysates by frit-fast atom bombardment liquid chromatography/mass spectrometry

1994 • 8 citations

Heterogeneity of hemoglobin A1d: assessment and partial characterization of two new minor hemoglobins, A1d3a and A1d3b, increased in uremic and diabetic patients, respectively

1996 • 7 citations

Rapid assay for furancarboxylic acid accumulated in uremic serum using high-performance liquid chromatography and on-line mass spectrometry

1994 • 6 citations

Relation of Endogenous Systemic and Brain Angiotensin II, Arginine Vasopressin and Prolactin with the Genesis of Salt Appetite in Cattle

1988 • 5 citations

Purification and biochemical characterization of xanthopterin from patients with chronic renal failure. II. Biochemical elucidation and structural analysis

1991 • 5 citations

Drug Interaction in Middle Molecule Analysis, with Special Reference to Acetylsalicylic Acid

1984 • 4 citations

Measurement of inositol in uremic serum by selected ion monitoring.

1988 • 4 citations

Bound amino acids in uremic sera: Search for peptidic middle molecules by preparative polyacrylamide gel electrophoresis and high performance liquid chromatography

1989 • 4 citations

Heterogeneity of hemoglobin A-1d: Assessment and partial characterization of two new minor hemoglobins, A-1d3a and A-1d3b, increased in uremic and diabetic patients, respectively

1996 • 3 citations

Isolation of Unusually Composed Sialyl-Compounds from Hemofiltrate

1989 • 2 citations