Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes

Prediction of Creatinine Clearance from Serum Creatinine

1976 • 15,066 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

1969 • 1,846 citations

Plasma Homocysteine as a Risk Factor for Vascular Disease

1997 • 1,770 citations

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

1992 • 1,686 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

The natural history of homocystinuria due to cystathionine beta-synthase deficiency.

1985 • 1,251 citations

Adequacy of dialysis and nutrition in continuous peritoneal dialysis

1996 • 1,074 citations

Disorders of transsulfuration

1989 • 1,053 citations

Total homocysteine in plasma or serum: methods and clinical applications

1993 • 996 citations

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 • 933 citations

Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men

1995 • 899 citations

Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis.

1994 • 812 citations

Cardiovascular disease after renal transplantation.

1996 • 680 citations

Serum Total Homocysteine and Coronary Heart Disease

1995 • 668 citations

The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine

1992 • 562 citations

Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.

1996 • 503 citations

Labile methyl balances for normal humans on various dietary regimens

1975 • 492 citations

Impact of hypertension on cardiomyopathy, morbidity and mortality in end-stage renal disease

1996 • 491 citations

Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury

1980 • 489 citations

Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia

1993 • 475 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.

1991 • 451 citations

Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatment

1990 • 397 citations

Homocysteine and cysteine: determinants of plasma levels in middle‐aged and elderly subjects

1994 • 392 citations

Coronary risk prediction in adults (The Framingham Heart Study)

1987 • 378 citations

Vitamin Requirements for the Treatment of Hyperhomocysteinemia in Humans

1994 • 373 citations

Folic acid—an innocuous means to reduce plasma homocysteine

1988 • 368 citations

Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency.

1980 • 355 citations

Hyperhomocysteinemia Confers an Independent Increased Risk of Atherosclerosis in End-Stage Renal Disease and Is Closely Linked to Plasma Folate and Pyridoxine Concentrations

1996 • 339 citations

Nutrition and mortality in hemodialysis.

1995 • 307 citations

Elevated Fasting Total Plasma Homocysteine Levels and Cardiovascular Disease Outcomes in Maintenance Dialysis Patients

1997 • 299 citations

Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry

1987 • 291 citations

Lipoprotein(a) is an independent risk factor for cardiovascular disease in hemodialysis patients.

1992 • 290 citations

Cardiovascular Risk Factors in Chronic Renal Failure and Hemodialysis Populations

1992 • 271 citations

Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism.

1992 • 265 citations

Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency

1993 • 265 citations

Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors

1992 • 261 citations

Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure

1997 • 251 citations

The effect of a subnormal vitamin B-6 status on homocysteine metabolism.

1996 • 245 citations

High dose B-vitamin treatment of hyperhomocysteinemia in dialysis patients

1996 • 242 citations

Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism

1994 • 237 citations

The effect of reduced glomerular filtration rate on plasma total homocysteine concentration

1996 • 233 citations

Higher total plasma homocysteine in vitamin B12 deficiency than in heterozygosity for homocystinuria due to cystathionine β-synthase deficiency

1988 • 227 citations

Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients.

1993 • 225 citations

Plasma Homocysteine in the Acute and Convalescent Phases After Stroke

1995 • 219 citations

Net uptake of plasma homocysteine by the rat kidney in vivo

1995 • 217 citations

Hyperhomocysteinemia-Induced Vascular Damage in the Minipig

1995 • 216 citations

Plasma homocysteine in acute myocardial infarction: homocysteine‐lowering effect of folic acid

1995 • 212 citations

Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits

1996 • 212 citations

Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat

1991 • 207 citations

Inherited disorders of folate transport and metabolism

1995 • 201 citations

Vitamin B−6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats

1994 • 198 citations

Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects

1989 • 197 citations

Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: Possible implications for prevention of vascular disease

1988 • 197 citations

Plasma homocysteine in renal failure.

1993 • 195 citations

Water soluble vitamins in chronic hemodialysis patients and need for supplementation

1993 • 181 citations

Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease

1994 • 180 citations

Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: a case-control study

1995 • 174 citations

Hyperhomocysteinemia and the risk for vascular disease in hemodialysis patients.

1995 • 173 citations

Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine‐homocysteine mixed disulphide

1979 • 171 citations

Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from The NHLBI Family Heart Study

1995 • 170 citations

HYPERHOMOCYSTEINEMIA IN CYCLOSPORINE-TREATED RENAL TRANSPLANT RECIPIENTS1

1996 • 168 citations

Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients

1995 • 162 citations

Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism.

1993 • 157 citations

The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients.

1993 • 154 citations

Relationship of coronary risk factors to hemodialysis-associated ischemic heart disease

1982 • 151 citations

Hyperhomocysteinaemia: a significant risk factor for cardiovascular disease in renal transplant recipients

1994 • 151 citations

Homocysteine in the Plasma of Renal Transplant Recipients: Effects of Cofactors for Methionine Metabolism

1981 • 144 citations

Mechanism of erythrocyte accumulation of methylation inhibitor S-adenosylhomocysteine in uremia

1995 • 120 citations

Hyperhomocysteinemia, hyperfibrinogenemia, and lipoprotein (a) excess in maintenance dialysis patients: a matched case-control study

1996 • 117 citations

Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients

1996 • 115 citations

Human arterial endothelial cell detachment in vitro: its promotion by homocysteine and cysteine

1991 • 113 citations

Development of Methyltransferase Activities of Human Fetal Tissues

1973 • 94 citations

Homocysteinemia and vascular disease in end-stage renal disease.

1996 • 93 citations

Accumulation of Sulphur-Containing Amino Acids Including Cysteine-Homocysteine in Patients on Maintenance Haemodialysis

1980 • 93 citations

Redox status and protein binding of plasma homocysteine and other aminothiols in patients with homocystinuria

1993 • 89 citations

Patterns of Fasting Plasma Amino Acid Levels in Chronic Renal Insufficiency: Results From the Feasibility Phase of the Modification of Diet in Renal Disease Study

1994 • 85 citations

Effects of Homocysteine and Related Compounds on Prostacyclin Production by Cultured Human Vascular Endothelial Cells

1993 • 84 citations

Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency

1996 • 76 citations

Folic acid treatment of hyperhomocysteinemia in dialysis patients.

1996 • 67 citations

Long-term folic acid (but not pyridoxine) supplementation lowers elevated plasma homocysteine level in chronic renal failure.

1996 • 65 citations

Homocystine uptake in isolated rat renal cortical tubules

1982 • 62 citations

Altered plasma free and protein-bound sulfur amino acid levels in patients undergoing maintenance hemodialysis

1987 • 61 citations

Pyridoxal 5′-phosphate deficiency in uremic undialyzed, hemodialyzed, and non-uremic kidney transplant patients

1983 • 57 citations

Increased plasma clearance of pyridoxal 5'-phosphate in vitamin B6-deficient uremic man.

1977 • 56 citations

Lack of effect of oral N-acetylcysteine on the acute dialysis-related lowering of total plasma homocysteine in hemodialysis patients

1996 • 53 citations

Effect of various regimens of vitamin B₆ and folic acid on mild hyperhomocysteinaemia in vascular patients

1994 • 52 citations

Major Role for Arterial Disease in Morbidity and Mortality After Kidney Transplantation in Diabetic Recipients

1991 • 49 citations

Red Cell and Plasma Amino Acid Concentrations in Renal Failure

1983 • 46 citations

Distribution of transsulphuration enzymes in various organs and species

1970 • 44 citations

The 1986 Borden Award Lecture. The role of the kidney in amino acid metabolism and nutrition

1987 • 40 citations

Cardiovascular Deaths among CAPD Patients

1983 • 37 citations

7 Inherited errors of cobalamin metabolism and their management

1995 • 37 citations

Comparative morbidity among hemodialysis and continuous ambulatory peritoneal dialysis patients.

1993 • 34 citations

Hyperhomocysteinemia as a possible role for atherosclerosis in CAPD patients.

1994 • 33 citations

Plasma amino acid abnormalities in chronic renal failure

1972 • 30 citations

Plasma Homocysteine and Methionine Tolerance in Early-Onset Vascular Disease

1989 • 29 citations

ACTIVITIES OF SOME ENZYMES INVOLVED IN HOMOCYSTEINE METHYLATION IN BRAIN, LIVER AND KIDNEY OF THE DEVELOPING RHESUS MONKEY

1976 • 22 citations

Hepatic Sulfur Amino Acid Metabolism in Rats with Chronic Renal Failure

1990 • 15 citations

Alternate reasons for atherogenesis in uremia.

1977 • 15 citations

Lower Fasting Total Plasma Homocysteine Levels in Stable Renal Transplant Recipients Versus Maintenance Dialysis Patients

1998 • 9 citations

Diminished serum folic acid levels in renal transplant recipients.

1982 • 9 citations

Homocysteine (Hcy) levels, placental vasculopathy and endothelial cell function

1995 • 7 citations

Activities of hepatic vitamin B6 metabolizing enzymes and concentrations of vitamin B6 vitamers in tissues of chronically azotemic rats

1995 • 5 citations

Deleted Work

1955 • 0 citations