Biochemical manifestations of diabetes mellitus in microscopic layers of the cornea and retina

Nonenzymatic Glycosylation and the Pathogenesis of Diabetic Complications

1984 • 1,012 citations

THE QUANTITATIVE HISTOCHEMISTRY OF THE RETINA

1956 • 928 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

The Sorbitol Pathway and the Complications of Diabetes

1973 • 750 citations

Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

1975 • 471 citations

Formation of Polyols by the Lens of the Rat with ‘Sugar’ Cataract

1959 • 431 citations

The metabolic basis to the fluid pump in the cornea

1972 • 425 citations

The location of the fluid pump in the cornea

1972 • 419 citations

The Oxygen Supply to the Retina, II. Effects of High Intraocular Pressure and of Increased Arterial Carbon Dioxide Tension on Uveal and Retinal Blood Flow in Cats

1972 • 409 citations

RPE destruction causes choriocapillary atrophy.

1984 • 371 citations

Corneal Endothelial Changes in Type I and Type II Diabetes Mellitus

1984 • 369 citations

Diabetic Maculopathy

1983 • 352 citations

Mechanisms initiating cataract formation. Proctor Lecture.

1974 • 304 citations

Contrast Sensitivity in Diabetics With and Without Background Retinopathy

1985 • 296 citations

Adaptation in Skate Photoreceptors

1972 • 292 citations

Correlation of light-induced changes in retinal extracellular potassium concentration with c-wave of the electroretinogram

1976 • 289 citations

Banting Lecture 1986: Does a Common Mechanism Induce the Diverse Complications of Diabetes?

1987 • 275 citations

The Retinal Pigment Epithelium

1980 • 268 citations

Insulin-Like Growth Factors in Vitreous: Studies in Control and Diabetic Subjects with Neovascularization

1986 • 255 citations

Neurochemical Correlates to Selective Neuronal Vulnerability

1985 • 252 citations

Impaired rat sciatic nerve sodium-potassium adenosine triphosphatase in acute streptozocin diabetes and its correction by dietary myo-inositol supplementation.

1983 • 246 citations

DIABETES, DIABETIC ANGIOPATHY, AND GROWTH HORMONE

1970 • 204 citations

The Natural History of Retinopathy in Insulin-Dependent Juvenile-Onset Diabetes

1981 • 197 citations

Nerve Conduction Changes in Experimental Diabetes*

1964 • 195 citations

Altered Retinal Vascular Response to 100% Oxygen Breathing in Diabetes Mellitus

1984 • 194 citations

Polyol Pathway Activity and Myo-Inositol Metabolism: A Suggested Relationship in the Pathogenesis of Diabetic Neuropathy

1983 • 183 citations

Factors Related to Corneal Epithelial Complications After Closed Vitrectomy in Diabetics

1979 • 182 citations

Color Vision Defects in Early Diabetic Retinopathy

1986 • 173 citations

Vascular basement membrane changes in diabetic retinopathy. Montgomery lecture, 1973.

1974 • 170 citations

Ocular Pathology of Diabetes Mellitus

1969 • 169 citations

POLYOL ACCUMULATIONS IN NERVOUS TISSUE OF RATS WITH EXPERIMENTAL DIABETES AND GALACTOSAEMIA *

1967 • 166 citations

Potassium and the photoreceptor-dependent pigment epithelial hyperpolarization.

1977 • 154 citations

Neurotrophic Corneal Ulcers in Diabetes Mellitus

1977 • 148 citations

Immunohistochemical Localization of Aldose Reductase: II. Rat Eye and Kidney

1980 • 148 citations

Sodium- and energy-dependent uptake of myo-inositol by rabbit peripheral nerve. Competitive inhibition by glucose and lack of an insulin effect.

1982 • 146 citations

Pars Plana Vitrectomy for the Management of Severe Diabetic Retinopathy

1976 • 137 citations

Corneal Sensitivity in Diabetics

1974 • 137 citations

Diminished ouabain-sensitive, sodium-potassium ATPase activity in sciatic nerves of rats with streptozotocin-induced diabetes

1976 • 135 citations

Predicting Progression to Severe Proliferative Diabetic Retinopathy

1987 • 129 citations

Corneal epithelial basement membrane changes in diabetes.

1981 • 123 citations

Metabolic alterations in the human erythrocyte produced by increases in glucose concentration

1971 • 122 citations

Corneal Complications After Closed Vitrectomy Through the Pars Plana

1978 • 117 citations

Retinal and choroidal contribution to retinal metabolism in vivo. A study in pigs

1979 • 114 citations

A Permeability Defect of the Retinal Pigment Epithelium

1980 • 113 citations

New approaches to ophthalmic electrodiagnosis by retinal oscillatory potential, drug-induced responses from retinal pigment epithelium and cone potential

1979 • 111 citations

Origin and sensitivity of the light peak in the intact cat eye

1982 • 110 citations

Protein Kinase C Agonists Acutely Normalize Decreased Ouabain-inhibitable Respiration in Diabetic Rabbit Nerve: Implications for (Na,K)-ATPase Regulation and Diabetic Complications

1986 • 109 citations

Clinicopathologic Study of Blood-Retinal Barrier in Experimental Diabetes Mellitus

1980 • 107 citations

Retinal Vascular Autoregulation in Conditions of Hyperoxia and Hypoxia Using the Blue Field Entoptic Phenomenon

1985 • 107 citations

Role of aldose reductase in the development of diabetes-associated complications

1985 • 105 citations

Temporal Aspects of the Electroretinogram in Diabetic Retinopathy

1987 • 103 citations

The effects of Sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat

1986 • 102 citations

Altered retinal metabolism in diabetes. II. Measurement of sodium-potassium ATPase and total sodium and potassium in individual retinal layers.

1986 • 102 citations

Phosphatidylinositol as the endogenous activator of the (Na+ + K+)-ATPase in microsomes of rabbit kidney

1978 • 98 citations

Altered retinal metabolism in diabetes. I. Microanalysis of lipid, glucose, sorbitol, and myo-inositol in the choroid and in the individual layers of the rabbit retina.

1986 • 90 citations

The Functional Reserve of Corneal Endothelium

1978 • 89 citations

Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy

1983 • 89 citations

Diabetic Polyneuropathy: The Importance of Insulin Deficiency, Hyperglycemia and Alterations in Myoinositol Metabolism in Its Pathogenesis

1976 • 88 citations

The Basement Membrane in the Human Diabetic Eye

1961 • 87 citations

Association between Colour Vision Losses and Diabetes mellitus

1972 • 87 citations

A Morphologic and Fluorophotometric Analysis of the Corneal Endothelium in Type I Diabetes Mellitus and Cystic Fibrosis

1985 • 86 citations

Sex Steroid Dependency of Diabetes-induced Changes in Polyol Metabolism, Vascular Permeability, and Collagen Cross-Linking

1986 • 85 citations

The Dual Function of Glucose in Islets of Langerhans

1971 • 83 citations

Early morphological alteration of the pigment epithelium in streptozotocin-induced diabetes: Increased surface area of the basal cell membrane

1980 • 77 citations

Metabolism of xylose by the lens. 2. Rat lens in vivo and in vitro

1959 • 76 citations

Disruption of blood-retinal barrier in experimental diabetic rats: An electron microscopic study

1980 • 76 citations

Basal phosphatidylinositol turnover controls aortic Na+/K+ ATPase activity.

1986 • 74 citations

Reduced Glomerular Sodium/Potassium Adenosine Triphosphatase Activity in Acute Streptozocin Diabetes and Its Prevention by Oral Sorbinil

1985 • 71 citations

Origin of the light peak: in vitro study of Gekko gekko

1982 • 69 citations

Corneal endothelial changes in diabetic dogs

1985 • 69 citations

Pathologic studies of the blood--retinal barrier in the spontaneously diabetic BB rat.

1984 • 68 citations

Effects of Elevated Glucose Concentrations on the Metabolism of the Aortic Wall

1972 • 67 citations

Reepithelialization of denuded corneas in diabetic rats

1980 • 66 citations

Corneal Hypesthesia and Retinopathy in Diabetes Mellitus

1980 • 64 citations

Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats.

1985 • 63 citations

Corneal re-epithelialization in galactosemic rats.

1983 • 63 citations

EFFECT OF MYO-INOSITOL ON PERIPHERAL-NERVE FUNCTION IN DIABETES

1978 • 62 citations

Intrinsic fluorescence emission from the cornea at low temperatures: Evidence of mitochondrial signals and their differing redox states in epithelial and endothelial sides

1978 • 59 citations

Role of nonenzymatic glycosylation in atherogenesis

1986 • 56 citations

Immunohistochemical localization of aldose reductase. II. Rat eye and kidney

1980 • 55 citations

Studies on the Pathophysiology of Diabetic Retinopathy: The Blood-Retinal Barrier in Diabetes

1983 • 55 citations

Sorbinil Prevents Diabetes-induced Increases in Vascular Permeability But Does Not Alter Collagen Cross-Linking

1985 • 54 citations

Laser Doppler Velocimetry in the Measurement of Retinal Blood Flow

1981 • 52 citations

Myoinositol uptake by four cultured mammalian cell lines

1986 • 52 citations

Diabetic complications: Early diagnosis and treatment

1987 • 42 citations

The effect of induced diabetes on the electroretinogram components of the pigmented rat.

1980 • 37 citations

A comparison of the effects of glucose and acetylcholine on insulin release and intermediary metabolism in rat pancreatic islets.

1979 • 37 citations

Pyridine nucleotides and phosphorylation potential of rabbit corneal epithelium and endothelium.

1989 • 33 citations

Properties of isolated nerve fibres from alloxanized rats.

1969 • 32 citations

The effects of aldose reductase inhibitor on the corneal endothelial morphology in diabetic rats

1987 • 31 citations

The active and passive transport of water across the corneal endothelium

1984 • 31 citations

The BB Wistar rat: An experimental model for the study of diabetic retinopathy

1983 • 30 citations

Sorbinil prevents diabetes-induced increases in vascular permeability but does not alter collagen cross-linking

1985 • 30 citations

Progressive ultrastructural damage and thickening of the basement membrane of the retinal pigment epithelium in spontaneously diabetic BB rats

1988 • 28 citations

Diabetes mellitus and the rabbit corneal epithelium.

1981 • 27 citations

Pyridine nucleotides of rabbit cornea with histotoxic anoxia: Chemical analysis, non-invasive fluorometry and physiological correlates

1983 • 26 citations

Electrophysiological Studies before and after Argon-Laser Photocoagulation in Diabetic Retinopathy

1978 • 25 citations

Fundus Diabeticus*

1965 • 22 citations

Reversal of Proteinuria by Sorbinil, an Aldose Reductase Inhibitor in Spontaneously Diabetic (BB) Rats

1988 • 20 citations

Insulin sensitivity and sorbitol production of the normal rabbit corneal epithelium in vitro.

1980 • 20 citations

NYCTOMETRY ‐ A NEW SCREENING METHOD FOR SELECTION OF PATIENTS WITH SIMPLE DIABETIC RETINOPATHY WHO ARE AT RISK OF DEVELOPING PROLIFERATIVE RETINOPATHY: Results of a 3‐year Follow‐up

1983 • 17 citations

Automated static perimetry to evaluate diabetic retinopathy.

1984 • 17 citations

Professor David Frederick Cole

1983 • 15 citations

ON THE SPATIAL ORGANIZATION OF THE CORNEA ENDOTHELIUM

1984 • 15 citations

The Role of the Polyol Pathway in Methaemoglobin Reduction in Human Red Cells

1974 • 15 citations

Altered redox states in corneal epithelium and endothelium: NADH fluorescence in rat and rabbit ocular tissue

1980 • 12 citations

Synergistic activation of retinal capillary pericyte proliferation in culture by inositol triphosphate and diacylglycerol

1987 • 8 citations

Ocular Pathology: A Color Atlas,

1988 • 6 citations

Ocular manifestations of diabetes.

1984 • 3 citations