BCL-2 Overexpression Attenuates Cortical Cell Loss after Traumatic Brain Injury in Transgenic Mice

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

mouse brain in stereotaxic coordinates

1997 • 3,077 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Manipulating the Mouse Embryo: A Laboratory Manual

2002 • 2,187 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model

1989 • 1,126 citations

A controlled cortical impact model of traumatic brain injury in the rat

1991 • 1,123 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus

1992 • 680 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

The Rotarod Test: An Evaluation of Its Effectiveness in Assessing Motor Deficits Following Traumatic Brain Injury

1994 • 616 citations

Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury

1997 • 584 citations

Experimental Brain Injury Induces Regionally Distinct Apoptosis during the Acute and Delayed Post-Traumatic Period

1998 • 532 citations

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

1995 • 517 citations

Extension of Sample Sizes and Percentage Points for Significance Tests of Outlying Observations

1972 • 494 citations

Neural apoptosis

1995 • 464 citations

A Model of Parasagittal Controlled Cortical Impact in the Mouse: Cognitive and Histopathologic Effects

1995 • 445 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat

1990 • 411 citations

Early Microvascular and Neuronal Consequences of Traumatic Brain Injury: A Light and Electron Microscopic Study in Rats

1994 • 357 citations

Evaluation of Memory Dysfunction Following Experimental Brain Injury Using the Morris Water Maze

1991 • 352 citations

Cognitive Deficits Following Traumatic Brain Injury Produced by Controlled Cortical Impact

1992 • 348 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Expression of bcl-2 From a Defective Herpes Simplex Virus–1 Vector Limits Neuronal Death in Focal Cerebral Ischemia

1995 • 297 citations

Concussive brain injury is associated with a prolonged accumulation of calcium: a45Ca autoradiographic study

1993 • 291 citations

Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat

1996 • 289 citations

bcl-2 transgene expression can protect neurons against developmental and induced cell death.

1995 • 261 citations

Apoptosis and Expression of Bcl-2 after Compression Trauma to Rat Spinal Cord

1996 • 259 citations

Apoptosis-Suppressor Genebcl-2Expression after Traumatic Brain Injury in Rats

1997 • 244 citations

Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats

1996 • 235 citations

Expression of bcl‐2 inhibits necrotic neural cell death

1995 • 216 citations

Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits

1996 • 204 citations

Delayed, selective neuronal death following experimental cortical impact injury in rats: possible role in memory deficits

1996 • 203 citations

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

1995 • 193 citations

Unilateral Cortical Contusion Injury in the Rat: Vascular Disruption and Temporal Development of Cortical Necrosis

1993 • 179 citations

Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc—superoxide dismutase transgenic mice

1996 • 173 citations

bcl-2 is expressed in neurons that survive focal ischemia in the rat

1995 • 169 citations

Role of calcium in central nervous system injuries.

1992 • 159 citations

Axonal response to traumatic brain injury: reactive axonal change, deafferentation, and neuroplasticity.

1992 • 157 citations

The Bcl-2 family of proteins, and the regulation of neuronal survival

1995 • 150 citations

Neuronal Cell Loss in the CA3 Subfield of the Hippocampus Following Cortical Contusion Utilizing the Optical Disector Method for Cell Counting

1997 • 139 citations

Herpes Simplex Viral Vectors Expressing Bcl-2 Are Neuroprotective When Delivered After a Stroke

1997 • 135 citations

THE CONTUSION INDEX: A REAPPRAISAL IN HUMAN AND EXPERIMENTAL NON‐MISSILE HEAD INJURY

1985 • 129 citations

Long-Term Persisting Cognitive Sequelae of Traumatic Brain Injury and the Effect of Age

1996 • 115 citations

Hippocampal pathology in fatal non-missile human head injury

1992 • 111 citations

Expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and Bcl-2 protooncogene protein by Müller (glial) cells in retinal light damage of rats

1995 • 110 citations

Selective Loss of Neurons From the Thalamic Reticular Nucleus Following Severe Human Head Injury

1993 • 107 citations

Transgenic Mice and Knockout Mutants in the Study of Oxidative Stress in Brain Injury

1995 • 106 citations

The 5'-flanking region of the rat synapsin I gene directs neuron-specific and developmentally regulated reporter gene expression in transgenic mice.

1993 • 95 citations

Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimerʼs disease

1996 • 92 citations

Role of Bcl‐2 in the Brain‐derived Neurotrophic Factor Survival Response

1995 • 88 citations

Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl‐2 expression is increased in unaffected post‐central gyrus

1995 • 82 citations

Time course of axotomy-induced apoptotic cell death in facial motoneurons of neonatal wild type and bcl-2 transgenic mice

1996 • 81 citations

Traumatic brain injury of the forelimb and hindlimb sensorimotor areas in the rat: physiological, histological and behavioral correlates

1996 • 70 citations

The Pathobiology of Traumatic Brain Injury

1997 • 57 citations

A bcl-2 expressing viral vector protects cortical neurons from excitotoxicity even when administered several hours after the toxic insult

1996 • 45 citations

Mutant and native human β-amyloid precursor proteins in transgenic mouse brain

1995 • 39 citations

In Memoriam

1992 • 37 citations

Neuropsychological outcome and quantitative image analysis of acute haemorrhage in traumatic brain injury: Preliminary findings

1994 • 33 citations

Positive- and negative-acting promoter sequences regulate cell type-specific expression of the rat synapsin I gene

1991 • 22 citations