Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats
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References (36)
Molecular Cloning: A Laboratory Manual
2001 • 133,517 citations
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
1987 • 64,270 citations
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
1987 • 45,673 citations
Reversible middle cerebral artery occlusion without craniectomy in rats.
1989 • 6,875 citations
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
1993 • 6,009 citations
Bcl-2 and the regulation of programmed cell death
1994 • 2,346 citations
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
1994 • 2,141 citations
Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
1994 • 1,106 citations
Apoptotic cell death induced by c-myc is inhibited by bcl-2
1992 • 981 citations
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.
1994 • 664 citations
Regulators of cell death
1995 • 647 citations
Programmed cell death and Bcl-2 protection in very low oxygen
1995 • 638 citations
bcl-2 inhibits death of central neural cells induced by multiple agents.
1993 • 631 citations
Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.
1989 • 516 citations
Temporal Profile of in situ DNA Fragmentation after Transient Middle Cerebral Artery Occlusion in the Rat
1995 • 477 citations
Immunohistochemical analysis of in vivo patterns of Bcl-X expression.
1994 • 429 citations
Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.
1994 • 377 citations
Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels.
1995 • 356 citations
Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.
1993 • 286 citations
Regional Protein Synthesis in Rat Brain Following Acute Hemispheric Ischemia
1980 • 231 citations
Endonuclease activation following focal ischemic injury in the rat brain
1993 • 211 citations
Effects of cycloheximide on delayed neuronal death in rat hippocampus
1990 • 202 citations
Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain
1994 • 197 citations
Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus
1994 • 197 citations
p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.
1994 • 183 citations
In situ hybridization analysis of c-fos and c-jun expression in the rat brain following transient forebrain ischemia
1991 • 180 citations
bcl-2 is expressed in neurons that survive focal ischemia in the rat
1995 • 169 citations
Induction of c-Fos, junB, c-Jun, and hsp70 mRNA in Cortex, Thalamus, Basal Ganglia, and Hippocampus following Middle Cerebral Artery Occlusion
1994 • 150 citations
Altered gene expression in cerebral ischemia.
1993 • 146 citations
Focal ischemia in rats causes time-dependent expression of c-fos protein immunoreactivity in widespread regions of ipsilateral cortex
1991 • 146 citations
Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.
1995 • 137 citations
Halothane Reduces Focal Ischemic Injury in the Rat When Brain Temperature Is Controlled
1995 • 102 citations
Cycloheximide Reduces the Effects of Anoxic InsultIn VivoandIn Vitro
1992 • 67 citations
The molecular mechanisms of neuronal apoptosis
1994 • 64 citations
Experimental stroke in gerbils: Effect on translation and transcription
1978 • 39 citations
Differential regulation ofbcl-2,bax,c-fos,junB, andkrox-24expression in the cerebellum of Purkinje cell degeneration mutant mice
1995 • 33 citations