Identification of Novel Pax-2 Binding Sites by Chromatin Precipitation

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans

1994 • 1,075 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

1992 • 692 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system

1990 • 562 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis

1991 • 443 citations

Pax: A murine multigene family of paired box-containing genes

1991 • 427 citations

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

1992 • 417 citations

Spatially and temporally restricted expression of Pax2 during murine neurogenesis

1990 • 397 citations

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1993 • 391 citations

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes.

1994 • 364 citations

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.

1994 • 361 citations

Mapping polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin

1993 • 360 citations

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1991 • 349 citations

Crystal structure of a paired domain-DNA complex at 2.5 å resolution reveals structural basis for pax developmental mutations

1995 • 325 citations

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

1992 • 325 citations

undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1

1988 • 323 citations

DNA-Binding and Transactivation Properties of Pax-6: Three Amino Acids in the Paired Domain Are Responsible for the Different Sequence Recognition of Pax-6 and BSAP (Pax-5)

1995 • 297 citations

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

1993 • 284 citations

More is better: Activators and repressors from the same gene

1992 • 280 citations

Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development

1993 • 273 citations

Repression of Pax-2 by WT1 during normal kidney development

1995 • 265 citations

Pax: Gene regulators in the developing nervous system

1993 • 195 citations

Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish

1992 • 169 citations

Targets of homeotic gene control in Drosophila

1990 • 159 citations

Kidney and Retinal Defects (Krd), a Transgene-Induced Mutation with a Deletion of Mouse Chromosome 19 That Includes the Pax2 Locus

1994 • 156 citations

NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation.

1993 • 151 citations

Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.

1993 • 150 citations

Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos.

1994 • 112 citations

A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl controlled by Hox-C8 in vivo

1993 • 108 citations

Connectin, a target of homeotic gene control inDrosophila

1992 • 107 citations

Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene.

1995 • 104 citations

The murine Ig 3' alpha enhancer is a target site with repressor function for the B cell lineage-specific transcription factor BSAP (NF-HB, S alpha-BP).

1994 • 101 citations

Homeotic control in Drosophila; the scabrous gene is an in vivo target of Ultrabithorax proteins.

1992 • 81 citations

Distinct Functional Properties of Three Human Paired-Box-Protein, PAX8, Isoforms Generated by Alternative Splicing in Thyroid, Kidney and Wilms' Tumors

1995 • 70 citations

A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation.

1989 • 65 citations

A nuclear DNA-binding protein expressed during early stages of B cell differentiation interacts with diverse segments within and 3' of the Ig H chain gene cluster.

1992 • 64 citations

Murine Pax-2 Protein Is a Sequence-SpecificTrans-Activator with Expression in the Genital System

1993 • 58 citations

A pre‐B‐ and B cell‐specific DNA‐binding protein, EBB‐1, which binds to the promoter of the V_preB1 gene

1992 • 54 citations

Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains

1994 • 48 citations

Binding and activation of the promoter for the neural cell adhesion molecule by Pax-8.

1994 • 43 citations

Properties of B cell stage specific and ubiquitous nuclear factors binding to immunoglobulin heavy chain gene switch regions

1992 • 42 citations

Aberrant Expression of Pax-2 in Danforth's Short Tail (Sd) Mice

1993 • 40 citations

On the Recovery of Genetically Engineered Proteins fromEscherichia coli

1986 • 32 citations

Isolation of a thyroid hormone-responsive gene by immunoprecipitation of thyroid hormone receptor-DNA complexes.

1994 • 23 citations

Characterisation of T48, a target of homeotic gene regulation in Drosophila embryogenesis

1994 • 19 citations

PAX genes in human developmental anomalies

1994 • 7 citations