c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

1997 • 462 citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

1997 • 451 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers.

1993 • 323 citations

UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways

1995 • 223 citations

Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase.

1996 • 168 citations

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.

1992 • 138 citations

Conformation-dependent phosphorylation of p53

1997 • 120 citations

Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain.

1996 • 118 citations

Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases.

1992 • 106 citations

Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.

1995 • 102 citations

Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation

1994 • 97 citations

Ubiquitin is a component of the microtubule network.

1988 • 88 citations

Complexes of p21RAS with JUN N-terminal kinase and JUN proteins.

1995 • 74 citations

jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells.

1995 • 65 citations

Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer.

1992 • 53 citations

Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.

1995 • 46 citations

Differential Regulation of c-Jun and JunD by Ubiquitin-Dependent Protein Degradation

1996 • 40 citations

A peptide encoding the c-Jun delta domain inhibits the activity of a c-jun amino-terminal protein kinase

1994 • 35 citations

In vivo association of ATFa with JNK/SAP kinase activities.

1996 • 23 citations

UV‐responsive element (TGACAACA) from rat fibroblasts to human melanomas

1994 • 22 citations

Transcriptional activation by the v-Jun oncoprotein is independent of positive regulatory phosphorylation.

1994 • 17 citations