The relationships of aging changes in the basal ganglia to manifestations of Huntington's chorea

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Huntington's Chorea

1973 • 845 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

Alzheimer's Disease: Senile Dementia and Related Disorders

1979 • 801 citations

Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity

1977 • 716 citations

Aging and Extrapyramidal Function

1977 • 650 citations

Handbook of clinical neurology

1969 • 608 citations

Time course of nigrostriatal degeneration in parkinson's disease

1976 • 561 citations

HUNTINGTON'S CHOREA

1974 • 527 citations

ENZYMES ASSOCIATED WITH THE METABOLISM OF CATECHOLAMINES, ACETYLCHOLINE AND GABA IN HUMAN CONTROLS AND PATIENTS WITH PARKINSON'S DISEASE AND HUNTINGTON'S CHOREA

1976 • 452 citations

Receptor basis for dopaminergic supersensitivity in Parkinson's disease

1978 • 447 citations

Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type

1979 • 445 citations

Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

1978 • 401 citations

Catecholamine metabolism in the brains of ageing male mice

1973 • 349 citations

Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine Levels in human basal ganglia

1976 • 328 citations

Neurotransmitter receptor alterations in Parkinson's disease

1977 • 251 citations

The Regulation of Physiological Changes During Mammalian Aging

1976 • 245 citations

Enhancement of Dopamine-Stimulated Adenylate Cyclase Activity in Rat Caudate after Lesions in Substantia Nigra: Evidence for Denervation Supersensitivity

1974 • 228 citations

β-Adrenergic Receptors in Aged Rat Brain: Reduced Number and Capacity of Pineal Gland to Develop Supersensitivity

1978 • 226 citations

Age-related Changes in the Nigrostriatum: A Behavioral and Biochemical Analysis

1978 • 197 citations

Aging and brain enzymes

1971 • 195 citations

Choline acetylase and glutamic acid decarboxylase in Huntington's chorea

1973 • 180 citations

A Pharmacologic Analysis of Huntington’s Chorea

1970 • 146 citations

Human brain substance P: distribution in controls and Huntington's chorea

1978 • 137 citations

Alterations of brain neurotransmitter receptor binding in Huntington's chorea

1976 • 132 citations

Aging-induced Changes in Acetylcholine and Serotonin Content of Discrete Brain Nuclei

1977 • 131 citations

Evidence for a decrease in substance P content of substantia nigra in Huntington's chorea

1977 • 130 citations

Cyclic AMP and cyclic GMP accumulation in vitro in brain regions of young, old and aged rats

1978 • 125 citations

Catecholamine synthesis in brain of ageing rat

1978 • 119 citations

Properties of adenylate cyclase from senescent rat brain

1973 • 112 citations

Strain-dependent variations in number of midbrain dopaminergic neurones

1976 • 103 citations

Rigid and Akinetic Forms of Huntington's Chorea

1962 • 103 citations

Use of L-Dopa in the Detection of Presymptomatic Huntington's Chorea

1972 • 102 citations

Nerve Cell Loss with Aging in the Putamen

1978 • 101 citations

Neurobiology and pharmacology of Huntington's disease

1977 • 96 citations

PARKINSON'S DISEASE

1973 • 95 citations

Biochemical characterization of the muscarinic cholinergic receptor in human brain: alterations in Huntington's disease.

1978 • 92 citations

Effect of aging on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in the rat corpus striatum

1977 • 91 citations

Evidence on the cellular localization of adenyl cyclase in the neostriatum

1976 • 91 citations

Regional distribution of choline acetyltransferase in the human brain: changes in Huntington's chorea.

1975 • 90 citations

Kainic Acid Lesions of the Striatum Dissociate Amphetamine and Apomorphine Stereotypy: Similarities to Huntingdon's Chorea

1978 • 76 citations

PATHOLOGIC CHANGES IN HUNTINGTON'S CHOREA

1927 • 72 citations

High correlations between number of dopamine cells, dopamine levels and motor performance

1977 • 71 citations

Huntington's Disease: Regional alteration in muscarinic cholinergic receptor binding in human brain

1976 • 65 citations

Loss of striatal serotonin synaptic receptor binding induced by kainic acid lesions: correlations with Huntington's Disease¹

1977 • 63 citations

Aging and Neurotransmitter Systems

1978 • 57 citations

Apomorphine Hydrochloride-Induced Improvement in Huntington's Chorea

1978 • 56 citations

Age-Related Changes In Brain Catecholamines: A Synopsis Of Findings in C57BL/6J Mice and Other Rodent Models

1978 • 55 citations

Hereditary Predisposition in Drug-Induced Parkinsonism

1962 • 52 citations

Alterations of muscarinic cholinergic receprtors in the rat striatum after kainic acid injections

1978 • 36 citations

Loss of Choline Acetyltransferase Activity in Normal Aging and in Senile Dementia

1978 • 31 citations

The Relation of Sex of Affected Parent to the Age at Onset of Huntington's Disease

1973 • 28 citations

Brain Monoamines, Monoamine Metabolites and Enzymes in Physiological Ageing and Senile Dementia

1978 • 19 citations

Levodopa and Huntington's chorea

1976 • 13 citations

Quantitative correlation of dopamine-dependent adenylate cyclase with responses to levodopa in various mice.

1977 • 10 citations