Rapid desensitization of 5-HT1A receptors in Fawn-Hooded rats after chronic fluoxetine treatment

Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publication

1995 • 634 citations

The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments

1997 • 397 citations

Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists

1989 • 285 citations

Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo.

1995 • 278 citations

The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(DI-n-propylamino)tetralin (8-OH-DPAT)

1985 • 254 citations

Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat.

1991 • 251 citations

Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT

1985 • 241 citations

Serotonin receptor subtypes : basic and clinical aspects

1991 • 217 citations

The Serotonin Reuptake Inhibitor Paroxetin Is Superior to the Noradrenaline Reuptake Inhibitor Maprotiline in the Treatment of Premenstrual Syndrome

1995 • 210 citations

The pharmacology of the behavioral and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

1987 • 197 citations

Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the rat

1988 • 186 citations

A quantitative autoradiographic study of serotonin1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments.

1991 • 175 citations

Electrophysiological evidence for a functional differentiation between subtypes of the 5-HT1 receptor

1988 • 174 citations

Serotonin: Molecular Biology, Receptors and Functional Effects

1991 • 170 citations

Effect of Serotonin Uptake Inhibitors in Anxiety Disorders; a Double-blind Comparison of Clomipramine and Fluvoxamine

1987 • 161 citations

Selective activation of 5HT1A receptors induces lower lip retraction in the rat

1989 • 161 citations

Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine

1994 • 156 citations

A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors.

1997 • 148 citations

Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism

1992 • 140 citations

Long-term fluoxetine, but not desipramine, inhibits the ACTH and oxytocin responses to the 5-HT1A agonist, 8-OH-DPAT, in male rats

1993 • 138 citations

Pharmacological Characterisation of a Modified Social Interaction Model of Anxiety in the Rat

1985 • 132 citations

Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists.

1993 • 129 citations

Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock

1985 • 127 citations

Chronic treatment with citalopram facilitates the effect of a challenge dose on cortical serotonin output: role of presynaptic 5-HT1A receptors

1994 • 125 citations

Differential responsiveness of the rat dorsal and median raphe 5‐HT systems to 5‐HT₁ receptor agonists and p‐chloroamphetamine

1990 • 124 citations

Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat

1987 • 122 citations

Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletion

1987 • 121 citations

Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex

1999 • 121 citations

Modulation of 5‐HT release in the guinea‐pig brain following long‐term administration of antidepressant drugs

1994 • 120 citations

Inhibition of median and dorsal raphe neurones following administration of the selective serotonin reuptake inhibitor paroxetine

1995 • 116 citations

Effect of various antidepressant drugs on the spontaneous firing rate of locu coeruleus and dorsal raphe neurons of the rat

1979 • 115 citations

Evidence for a repetitive (burst) firing pattern in a sub-population of 5-hydroxytryptamine neurons in the dorsal and median raphe nuclei of the rat

1995 • 111 citations

Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obsessive-compulsive disorder

1991 • 105 citations

Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression

1990 • 103 citations

5-HT_1A Receptor Sensitivity in Major Depression

1994 • 103 citations

Food intake, neuroendocrine and temperature effects of 8-OHDPAT in the rat

1988 • 90 citations

5-HT1A Receptor Function in Normal Subjects on Clinical Doses of Fluoxetine Blunted Temperature and Hormone Responses to Ipsapirone Challenge

1999 • 89 citations

Anxiolytic-like effect of paroxetine in a rat social interaction test

1994 • 85 citations

Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the rat

1991 • 82 citations

Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat

1995 • 80 citations

Clinical pharmacology of anxiolytics and antidepressants: A psychopharmacological perspective

1989 • 80 citations

Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats

1995 • 80 citations

Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram

1995 • 76 citations

Evidence for postsynaptic mediation of the hypothermic effect of 5‐HT_1A receptor activation

1992 • 75 citations

Lack of 5-HT1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis

1994 • 75 citations

Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter

1994 • 75 citations

Attenuation of hormone responses to the 5-HT1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats

1994 • 65 citations

Effects of acute and chronic fluoxetine treatment on CRH-induced anxiety

1999 • 62 citations

Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment1Parts of this data was presented at the 4th IUPHAR Satellite Meeting on Serotonin, Rotterdam, July 23–25, 1998.1

1999 • 59 citations

Regulation of 5-hydroxytryptamine1A receptor function in rat hippocampus by short- and long-term administration of 5-hydroxytryptamine1A agonist and antidepressants.

1992 • 55 citations

Altered responses to serotonergic agents in Fawn-Hooded rats

1985 • 53 citations

Effect of pindolol on thel-5-htp-induced increase in plasma prolactin and cortisol concentrations in man

1994 • 51 citations

A comparison of feeding and locomotion responses to serotonin agonists in three rat strains

1988 • 47 citations

Functional and biochemical evidence for altered serotonergic function in the Fawn-Hooded rat strain

1994 • 46 citations

Alcohol selection by strains of rats selectively bred for behavior.

1979 • 40 citations

Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists

1988 • 40 citations

Increased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety

1994 • 39 citations

Effect of repeated electroconvulsive shocks on serotonergic neurons

1992 • 38 citations

Serotonin uptake blockers inhibit the firing of presumed serotonergic dorsal raphe neurons in vitro

1991 • 36 citations

Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission

1999 • 35 citations

Antagonism of 8-OH-DPAT-induced behaviour in rats

1990 • 35 citations

5-HT1A-mediated lower lip retraction: Effects of 5-HT1A agonists and antagonists

1993 • 34 citations

5-HT1A receptor blockers as potential drug candidates for the treatment of anxiety disorders

1999 • 33 citations

Comparison of relative potencies of i.v. and i.c.v. administered 8-OH-DPAT gives evidence of different sites of action for hypothermia, lower lip retraction and tail flicks

1997 • 32 citations

Regional analysis of 5-HT1A and 5-HT2 receptors in the Fawn-Hooded rat

1992 • 32 citations

Effect of repeated treatment with electroconvulsive shock (ECS) on serotonin receptor density and turnover in the rat cerebral cortex

1991 • 29 citations

Chronic electroconvulsive shock and 5-HT autoreceptor activity in rat brain: an in vivo microdialysis study

1997 • 27 citations

Role of dorsal and median raphe nuclei in lower lip retraction in rats

1994 • 27 citations

Platelet storage pool disease in hybrid rats

1984 • 25 citations

Human platelet serotonin content: methodological aspects and physiological variations.

1988 • 23 citations

Thermoregulatory responses following injection of 5-hydroxytryptamine into the septohippocampal complex in rats

1993 • 15 citations

Emotional reactivity and alcohol preference among genetic crosses of the Maudsley and Roman rats

1986 • 13 citations

Differentiation of 8-OH-DPAT and Ipsapirone in Rat Models of 5-HT1A Receptor Function

1991 • 13 citations

The effect of chronic administration of antidepressants and electroconvulsive shock on the 5-HT1A receptor mediated hypothekmic response induced by 8-OH-DPAT in the rat

1994 • 11 citations

Consequences of 5‐HT Re‐uptake Blockade on Postsynaptic 5‐HT_1A Receptor Activation: An Electrophysiological and Neurochemical Study in Guinea Pig Dorsal Raphe and Hippocampus

1998 • 3 citations

Cited By (0)

Loading...