Amino acid substitutions that increase the thermal stability of the λ Cro protein

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli

1983 • 810 citations

Structure of the cro repressor from bacteriophage λ and its interaction with DNA

1981 • 545 citations

Construction of plasmids carrying the cI gene of bacteriophage lambda.

1976 • 410 citations

The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli

1989 • 326 citations

Identification of clones that encode chicken tropomyosin by direct immunological screening of a cDNA expression library.

1983 • 307 citations

The molecular basis of DNA–protein recognition inferred from the structure of cro repressor

1982 • 303 citations

A General Method for Saturation Mutagenesis of Cloned DNA Fragments

1985 • 292 citations

Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation

1986 • 275 citations

Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein

1987 • 253 citations

GENETIC ANALYSIS OF STAPHYLOCOCCAL NUCLEASE: IDENTIFICATION OF THREE INTRAGENIC "GLOBAL" SUPPRESSORS OF NUCLEASE-MINUS MUTATIONS

1985 • 189 citations

Effect of single amino acid replacements on the thermal stability of the NH2-terminal domain of phage lambda repressor.

1984 • 153 citations

Mechanism of action of the cro protein of bacteriophage lambda.

1978 • 145 citations

Bacteriophage lambda cro mutations: effects on activity and intracellular degradation.

1986 • 145 citations

Mutations in lambda repressor's amino-terminal domain: implications for protein stability and DNA binding.

1983 • 139 citations

Lambda repressor mutations that increase the affinity and specificity of operator binding

1985 • 136 citations

Is protein turnover thermodynamically controlled?

1978 • 97 citations

Comparison of the structures of Cro and λ repressor proteins from bacteriophage λ

1983 • 91 citations

Effect on protein stability of reversing the charge on amino groups

1982 • 89 citations

Minimal size plasmids containing an M13 origin for production of single-strand transducing particles.

1984 • 82 citations

Identification of C-terminal extensions that protect proteins from intracellular proteolysis

1989 • 76 citations

Tryptophan biosynthesis in Escherichia coli. Genetic determination of the proteins involved.

1971 • 70 citations

Phage lambda repressor revertants

1985 • 61 citations

Purification and properties of a DNA-binding protein with characteristics expected for the Cro protein of bacteriophage lambda, a repressor essential for lytic growth.

1976 • 51 citations

Increasing and decreasing protein stability: Effects of revertant substitutions on the thermal denaturation of phage λ repressor

1985 • 42 citations

Tryptophan biosynthesis in Escherichia coli. Genetic determination of the proteins involved

1971 • 7 citations