Lambda repressor mutations that increase the affinity and specificity of operator binding

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Experiments in molecular genetics

1972 • 28,260 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

Ion effects on ligand-nucleic acid interactions

1976 • 1,016 citations

Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli

1983 • 810 citations

Computational crystallography

2012 • 705 citations

Structure of the cro repressor from bacteriophage λ and its interaction with DNA

1981 • 545 citations

The operator-binding domain of λ repressor: structure and DNA recognition

1982 • 528 citations

How the λ repressor and cro work

1980 • 452 citations

The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotes

1975 • 341 citations

Interactions between DNA-bound repressors govern regulation by the λ phage repressor

1979 • 329 citations

Repressor structure and the mechanism of positive control

1983 • 324 citations

Nonspecific interaction of lac repressor with DNA: an association reaction driven by counterion release

1977 • 262 citations

Interpretation of monovalent and divalent cation effects on the lac repressor-operator interaction

1977 • 251 citations

Gene regulation at the right operator (OR) of bacteriophage λ

1980 • 241 citations

The lambda repressor contains two domains.

1979 • 238 citations

Maximizing gene expression on a plasmid using recombination in vitro

1978 • 200 citations

[76] Bacteriophage λ repressor and cro protein: Interactions with operator DNA

1980 • 154 citations

A large increase in enzyme–substrate affinity by protein engineering

1984 • 147 citations

Mechanism of action of the cro protein of bacteriophage lambda.

1978 • 145 citations

Regulatory functions of the λ repressor reside in the amino-terminal domain

1979 • 143 citations

DNA sequence of the bacteriophage λ cI gene

1978 • 121 citations

How do genome-regulatory proteins locate their DNA target sites?

1982 • 117 citations

The and 434 Phage Repressors

1970 • 116 citations

Comparison of the structures of Cro and λ repressor proteins from bacteriophage λ

1983 • 91 citations

Structure of the Operator-binding Domain of Bacteriophage Repressor: Implications for DNA Recognition and Gene Regulation

1983 • 65 citations

Tight-binding repressors of the lactose operon

1976 • 64 citations

A Genetic Switch in a Bacterial Virus

1982 • 62 citations

Phage lambda repressor revertants

1985 • 61 citations

Mutations Defining the Operator-binding Sites of Bacteriophage Repressor

1983 • 50 citations

Increasing and decreasing protein stability: Effects of revertant substitutions on the thermal denaturation of phage λ repressor

1985 • 42 citations

Characteristics of tight binding repressors of the lac operon

1981 • 28 citations

Tight-binding repressors of the lac operon: selection system and in vitro analysis

1979 • 17 citations