Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

O-phthalaldehyde: fluorogenic detection of primary amines in the picomole range. Comparison with fluorescamine and ninhydrin.

1975 • 738 citations

[36] High-sensitivity sequencing with a gas-phase sequenator

1983 • 670 citations

Human thrombins. Production, evaluation, and properties of alpha-thrombin.

1977 • 587 citations

Redesigning Trypsin: Alteration of Substrate Specificity

1985 • 357 citations

Three-dimensional Structure of Tosyl-elastase

1970 • 299 citations

Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin

1983 • 299 citations

Computer-generated models of blood coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases.

1982 • 220 citations

Primary structure of human prethrombin 2 and alpha-thrombin.

1977 • 168 citations

Solution composition dependent variation in extinction coefficients for p-Nitroaniline

1983 • 149 citations

The Hemorrhagic Diseases and the Pathology of Hemostasis.

1975 • 131 citations

Substrate specificity of human pancreatic elastase 2

1980 • 108 citations

The specificity of purified porcine pancreatic elastase

1969 • 105 citations

Characterization of bovine prothrombin mRNA and its translation product

1984 • 94 citations

Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

1982 • 94 citations

CONGENITAL HYPOPROTHROMBINEMIC STATES

1955 • 72 citations

p‐Nitroanilides of 3‐Carboxypropionyl‐peptides

1976 • 61 citations

Hemoglobin Savannah (B6(24) β-glycine→valine): an unstable variant causing anemia with inclusion bodies

1971 • 60 citations

Evidence for the amino acid sequence of porcine pancreatic elastase

1973 • 55 citations

Rapid postsynthetic destruction of unstable haemoglobin Bushwick

1975 • 55 citations

Identification of the primary structural defect in the dysthrombin thrombin Quick I: substitution of cysteine for arginine-382

1988 • 48 citations

Prothrombin Tokushima, a replacement of arginine-418 by tryptophan that impairs the fibrinogen clotting activity of derived thrombin Tokushima

1987 • 42 citations

Thrombin-catalyzed hydrolysis of p-nitrophenyl esters

1962 • 40 citations

Identification of a congenital dysthrombin, thrombin Quick.

1980 • 33 citations

Characterization of the catalytic defect in the dysthrombin, Thrombin Quick.

1987 • 15 citations