Apoptotic proteins in the course of aging of central nervous system in the rat

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

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1992 • 9,540 citations

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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Cell Death During Development of the Nervous System

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Double identity for proteins of the Bcl-2 family

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Molecular thanatopsis: a discourse on the BCL2 family and cell death

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Life and Death of Neurons in the Aging Brain

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Role of poly(ADP-ribose) formation in DNA repair

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XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

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Neocortical cell counts in normal human adult aging

1987 • 676 citations

Caspases and caspase inhibitors

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Upregulation of bax protein levels in neurons following cerebral ischemia

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Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span.

1992 • 295 citations

A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis

1992 • 270 citations

Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase

1998 • 237 citations

Increased Apoptosis of T Cell Subsets in Aging Humans: Altered Expression of Fas (CD95), Fas Ligand, Bcl-2, and Bax

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Structure—Function Analysis of Bcl-2 Family Proteins

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Age-Associated Changes in the DNA of Mouse Tissue

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Technical tips

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Neuron atrophy during aging: programmed or sporadic?

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Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

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Senescent microstructural changes in rat cerebellum

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Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1

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Mitochondrial biology, degenerative diseases and aging

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Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum

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Qualitative and quantitative estimates of apoptosis from birth to senescence in the rat brain

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Endothelial dysfunction in aging animals: the role of poly(ADP‐ribose) polymerase activation

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Enzymatic repair of oxidative DNA damage.

1994 • 77 citations

Oxidative‐stress‐dependent up‐regulation of Bcl‐2 expression in the central nervous system of aged Fisher‐344 rats

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bcl-2 protein expression in aged brain and neurodegenerative diseases

1994 • 71 citations

Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats

1996 • 69 citations

Differential Expression of Rat Brain Bcl-2 Family Proteins in Development and Aging

1998 • 67 citations

Identification of neuronal programmed cell death in situ in the striatum of normal adult rat brain and its relationship to neuronal death during aging

1995 • 50 citations

Differential Expression of Rat Brain Caspase Family Proteins during Development and Aging

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Dying-back of Purkinje cell dendrites with synapse loss in aging rats.

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Excitatory Amino Acid Receptors and Depolarization-Induced Ca²⁺Influx into Hippocampal Slices

1987 • 45 citations

Age-dependent variation of rates of polyadenosine-diphosphoribose synthesis by cardiocyte nuclei and the lack of correlation of enzymatic activity with macromolecular size distribution of DNA.

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Aging Splenocyte and Thymocyte Apoptosis Is Associated with Enhanced Expression of p53, Bax, and Caspase-3

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Cellular content of p53 protein in rat skin after exposure to the space environment

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Accumulation of DNA Damage in Aging Neurons Occurs Through a Mechanism Other than Apoptosis

1996 • 38 citations

Age-related changes in the cerebellum: parallel fibers

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Down-Regulation of Ku Autoantigen, DNA-Dependent Protein Kinase, and Poly(ADP-ribose) Polymerase during Cellular Senescence

1997 • 32 citations

Age-related alteration of poly(ADP-ribose) polymerase activity in different parts of the brain.

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Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology

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Analysis of chromatin of the brain of young and old rats by micrococcal nuclease and DNase I.

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Age-related quantitative changes in the organelles of rat neocerebellar Purkinje cells.

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ADP-ribosylation of nuclear proteins in rat ventral prostate during ageing

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Altered conformation and increased strand breaks in neuronal and astroglial DNA of aging rat brain.

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Age‐Associated Changes of Rat Brain Neuronal and Astroglial Poly(ADP‐Ribose) Polymerase Activity

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Acid phosphatase activity in human neuronal and glial lipofuscin

1984 • 10 citations