Endothelial dysfunction in aging animals: the role of poly(ADP‐ribose) polymerase activation

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

1998 • 1,494 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

Aging and Endothelial Function in Normotensive Subjects and Patients With Essential Hypertension

1995 • 730 citations

Enhanced Peroxynitrite Formation Is Associated with Vascular Aging

2000 • 653 citations

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

2001 • 609 citations

What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?

1997 • 480 citations

Superoxide Excess in Hypertension and Aging

2001 • 444 citations

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

1999 • 368 citations

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

1997 • 368 citations

Genetic Disruption of Poly (ADP-Ribose) Synthetase Inhibits the Expression of P-Selectin and Intercellular Adhesion Molecule-1 in Myocardial Ischemia/Reperfusion Injury

1998 • 334 citations

Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia–reperfusion injury in the heart and skeletal muscle

1997 • 310 citations

Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta

1995 • 287 citations

The Role of Poly(ADP-Ribose) Polymerase Activation in the Development of Myocardial and Endothelial Dysfunction in Diabetes

2002 • 283 citations

Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase

1997 • 225 citations

Rapid Reversal of the Diabetic Endothelial Dysfunction by Pharmacological Inhibition of Poly(ADP-Ribose) Polymerase

2001 • 196 citations

Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase

2000 • 194 citations

Myocardial Postischemic Injury Is Reduced by PolyADPribose Polymerase-1 Gene Disruption

2000 • 153 citations

Vascular bed heterogeneity in age‐related endothelial dysfunction with respect to NO and eicosanoids

2000 • 131 citations

Cyclo‐oxygenase‐1 and −2 contribution to endothelial dysfunction in ageing

2000 • 103 citations

Aging and Severity of Hypertension Attenuate Endothelium-Dependent Renal Vascular Relaxation in Humans

1997 • 102 citations

Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin.

1990 • 88 citations

Cell Death

2000 • 67 citations

Role of lipid peroxidation and the glutathione‐dependent antioxidant system in the impairment of endothelium‐dependent relaxations with age

1998 • 51 citations

Nitric Oxide-Dependent Vasodilator Mechanism is Not Impaired by Hypertension But is Diminished with Aging in the Rat Aorta

1999 • 45 citations

Role of Free Radicals in and around Vascular Endothelial Cells in the Mechanism of Aginga

1996 • 7 citations