Cytokine modulation of mycobacterium tuberculosis growth in human macrophages

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Separation of leukocytes from blood and bone marrow

1968 • 2,787 citations

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

T‐Cell Growth Factor

1980 • 917 citations

The Role of Cell-Mediated Immunity in Bacterial Infections

1981 • 452 citations

Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine.

1983 • 404 citations

Tumor necrosis factor, alone or in combination with IL-2, but not IFN-gamma, is associated with macrophage killing of Mycobacterium avium complex.

1988 • 378 citations

Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria

1985 • 315 citations

Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis.

1987 • 310 citations

Adoptive protection of the Mycobacterium tuberculosis-infected lung

1984 • 229 citations

The role of gamma-interferon, vitamin D3 metabolites and tumour necrosis factor in the pathogenesis of tuberculosis.

1987 • 215 citations

Mycobacteria‐reactive Lyt‐2⁺ T cell lines

1988 • 175 citations

Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila.

1986 • 173 citations

A simple method for counting adherent cells: Application to cultured human monocytes, Macrophages and multinucleated giant cells

1983 • 166 citations

Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection.

1988 • 150 citations

Interleukin 2 receptors are expressed by alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine treatment of normal human lung macrophages, blood monocytes, and monocyte cell lines.

1987 • 105 citations

Inhibition by retinoic acid of multiplication of virulent tubercle bacilli in cultured human macrophages

1989 • 85 citations

The role of T cell — Macrophage interactions in tuberculosis

1988 • 67 citations

Cytokine regulation of the intracellular growth of Mycobacterium paratuberculosis in bovine monocytes

1988 • 65 citations

Inhibition by streptomycin of tubercle bacilli within cultured human macrophages.

1984 • 51 citations

Lysis of mycobacteria-infected monocytes by IL-2-activated killer cells: Role of LFA-1

1989 • 49 citations

Progress in the immunology of the mycobacterioses.

1987 • 45 citations

Inhibition of virulent Mycobacterium tuberculosis by murine peritoneal macrophagesand human alveolar lavage cells: The effects of lymphokines and recombinant gamma interferon

1986 • 36 citations