IRS-1 expression and activation are not sufficient to activate downstream pathways and enable IGF-I growth response in estrogen receptor negative breast cancer cells

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity

1987 • 940 citations

Insulin-Like Growth Factors

1997 • 897 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

Untitled

1998 • 523 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Enhancement of Insulin-Like Growth Factor Signaling in Human Breast Cancer: Estrogen Regulation of Insulin Receptor Substrate-1 Expression in Vitro and in Vivo

1999 • 319 citations

Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase

1997 • 262 citations

ErbB-1 and ErbB-2 Acquire Distinct Signaling Properties Dependent upon Their Dimerization Partner

1998 • 259 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action

1996 • 255 citations

Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells

1997 • 212 citations

Insulin Receptor Substrate-1 is the Predominant Signaling Molecule Activated by Insulin-like Growth Factor-I, Insulin, and Interleukin-4 in Estrogen Receptor-positive Human Breast Cancer Cells

1998 • 174 citations

Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes

1998 • 169 citations

Overexpressed IGF-I Receptors Reduce Estrogen Growth Requirements, Enhance Survival, and Promote E-Cadherin-Mediated Cell–Cell Adhesion in Human Breast Cancer Cells

1997 • 136 citations

Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect.

1998 • 104 citations

MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer

1996 • 102 citations

YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation Sites

1996 • 91 citations

Transforming potential of the insulin receptor substrate 1.

1995 • 89 citations

Adenovirus-Mediated Overexpression of IRS-1 Interacting Domains Abolishes Insulin-Stimulated Mitogenesis without Affecting Glucose Transport in 3T3-L1 Adipocytes

1997 • 77 citations

Overexpression of insulin receptor substrate 1 (IRS-1) in the human breast cancer cell line MCF-7 induces loss of estrogen requirements for growth and transformation.

1995 • 74 citations

Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave

1996 • 64 citations

PDGF-mediated activation of phosphatidylinositol 3 kinase in human mesangial cells

1994 • 41 citations

Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase.

1995 • 40 citations

Paradoxical effects of overexpression of the type I insulin-like growth factor (IGF) receptor on the responsiveness of human breast cancer cells to IGFs and estradiol.

1996 • 34 citations

Insulin and insulin-like growth factor signaling are defective in the MDA MB-468 human breast cancer cell line.

1994 • 29 citations