Dynamics of the p53-Mdm2 feedback loop in individual cells

Surfing the p53 network

2000 • 6,487 citations

Network motifs in the transcriptional regulation network of Escherichia coli

2002 • 3,012 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation

2002 • 1,805 citations

Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

2003 • 1,596 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

The p53–Mdm2 module and the ubiquitin system

2002 • 759 citations

Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2

2003 • 738 citations

Cyclic, Proteasome-Mediated Turnover of Unliganded and Liganded ERα on Responsive Promoters Is an Integral Feature of Estrogen Signaling

2003 • 718 citations

Regulation and function of the p53 tumor suppressor protein

2001 • 716 citations

MDM2 — master regulator of the p53 tumor suppressor protein

2000 • 637 citations

Signaling to p53

1998 • 636 citations

Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study

2000 • 584 citations

Computational approaches to cellular rhythms

2002 • 575 citations

Heat shock factors and the control of the stress response

2000 • 568 citations

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1999 • 449 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

DnaK, DnaJ, and GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32.

1990 • 356 citations

PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy

2002 • 337 citations

Mdm2: keeping p53 under control

1997 • 267 citations

The BMP7/ActRII Extracellular Domain Complex Provides New Insights into the Cooperative Nature of Receptor Assembly

2003 • 264 citations

A THEORETICAL AND EXPERIMENTAL STUDY

1996 • 157 citations

Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System

2000 • 108 citations

p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.

2001 • 102 citations

Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter.

1987 • 87 citations

Regulation of p53 protein expression in human breast cancer cell lines

1993 • 85 citations

Ime2, a Meiosis-Specific Kinase in Yeast, Is Required for Destabilization of Its Transcriptional Activator, Ime1

2002 • 76 citations

Cyclin A-CDK Phosphorylation Regulates MDM2 Protein Interactions

2001 • 67 citations

POSSIBLE OSCILLATORY BEHAVIOR IN P53–MDM2 INTERACTION COMPUTER SIMULATION

2000 • 42 citations

Direct transactivation of c-Ha-Ras gene by p53: evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis

2000 • 28 citations