Different Frequency of Gene Targeting Events by the RNA-DNA Oligonucleotide Among Epithelial Cells

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

1993 • 1,102 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

Permanent coverage of large burn wounds with autologous cultured human epithelium

1985 • 1,022 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Location of stem cells of human hair follicles by clonal analysis

1994 • 521 citations

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

1989 • 510 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

p53 Mutations in human immortalized epithelial cell lines

1993 • 441 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Intracellular distribution of microinjected antisense oligonucleotides.

1991 • 362 citations

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

1995 • 351 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment.

1993 • 327 citations

Correction of the Mutation Responsible for Sickle Cell Anemia by an RNA-DNA Oligonucleotide

1996 • 318 citations

In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides

1998 • 263 citations

HUMAN GENE THERAPY

1993 • 262 citations

Inactivation of p53 results in high rates of homologous recombination

1997 • 225 citations

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

1993 • 224 citations

Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide.

1996 • 221 citations

Towards gene therapy for haemophilia B using primary human keratinocytes

1993 • 187 citations

Corrective gene transfer in the human skin disorder lamellar ichthyosis

1996 • 166 citations

Rapid nuclear accumulation of injected oligodeoxyribonucleotides.

1990 • 157 citations

DNA Loop Repair by Human Cell Extracts

1994 • 125 citations

Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide

1997 • 123 citations

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

1997 • 106 citations

Testing the Role of p53 in the Expression of Genetic Instability and Apoptosis in Ataxia-telangiectasia

1994 • 101 citations

Transport of oligonucleotides across natural and model membranes

1994 • 100 citations

Cationic Lipid Is Not Required for Uptake and Selective Inhibitory Activity of ICAM-1 Phosphorothioate Antisense Oligonucleotides in Keratinocytes

1994 • 94 citations

Sustainable cutaneous gene delivery

1997 • 88 citations

Cellular Uptake of Oligodeoxynucleotide Phosphorothioates and Their Analogs

1994 • 86 citations

In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes

1996 • 82 citations

Topical Application of Viral Vectors for Epidermal Gene Transfer

1997 • 82 citations

Characteristics of Oligonucleotide Uptake in Human Keratinocyte Cultures

1993 • 81 citations

Retrovirus-Mediated Transduction of Cultured Epidermal Keratinocytes

1991 • 74 citations

Differentiation-dependent p53 regulation of nucleotide excision repair in keratinocytes.

1997 • 67 citations

Targeted gene conversion in a mammalian CD34 + -enriched cell population using a chimeric RNA/DNA oligonucleotide

1997 • 53 citations

Characterization of homologous DNA recombination activity in normal and immortal mammalian cells

1996 • 33 citations

Differential Regulation of Gene Expressionin Vivoby Triple Helix-Forming Oligonucleotides as Detected by a Reporter Enzyme

1994 • 27 citations

Processing of three different types of DNA damage in cell lines of a cutaneous squamous cell carcinoma progression model

1997 • 21 citations

Failure of HPV E6 to rapidly degrade p53 in human HeLa×PNET cell hybrids

1997 • 11 citations

Chemically-induced unscheduled DNA synthesis in cultures of adult human epidermal keratinocytes

1993 • 4 citations