Polyamines as biomarkers of cervical intraepithelial neoplasia

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

1988 • 1,533 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Ornithine decarboxylase activity is critical for cell transformation

1992 • 630 citations

Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.

1993 • 220 citations

Spermine prevents endonuclease activation and apoptosis in thymocytes*1

1991 • 181 citations

Implications and concepts of polyamine‐nucleic acid interactions

1991 • 179 citations

Ca2+ influx via T-type channels modulates PDGF-induced replication of mouse fibroblasts

1993 • 166 citations

The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells.

1988 • 139 citations

Dose De-escalation Chemoprevention Trial of -Difluoromethylornithine in Patients With Colon Polyps

1994 • 101 citations

Effect of polyamine depletion on c-myc expression in human colon carcinoma cells.

1988 • 92 citations

Randomized Phase I Chemoprevention Dose-Seeking Study of -Difluoromethylornithine

1993 • 86 citations

Tumor Angiogenesis and Polyamines: α-Difluoromethylornithine, an Irreversible Inhibitor of Ornithine Decarboxylase, Inhibits B16 Melanoma-induced Angiogenesis in Ovo and the Proliferation of Vascular Endothelial Cells in Vitro

1990 • 80 citations

Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas.

1984 • 71 citations

Elevation of monoacetylated polyamines in human breast cancers

1985 • 49 citations

Evaluation of alpha-difluoromethylornithine as a potential chemopreventive agent: tolerance to daily oral administration in humans.

1993 • 36 citations

Inhibition of Carcinogenesis by Inhibitors of Putrescine Biosynthesis

1987 • 35 citations

Polyamines in normal and in virus-transformed chick embryo fibroblasts.

1974 • 33 citations

Chemoprevention of mouse colon tumors with difluoromethylornithine during and after carcinogen treatment.

1989 • 32 citations

Polyamines prevent DFMO-mediated inhibition of angiogenesis

1994 • 24 citations

Polyamine metabolism and interconversion in NIH 3T3 and ras-transfected NIH 3T3 cells.

1988 • 21 citations

Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition

1985 • 14 citations

Alterations in polyamine metabolism during continuous intravenous infusion of alpha-difluoromethylornithine showing correlation of thrombocytopenia with alpha-difluoromethylornithine plasma levels.

1989 • 12 citations

Deleted Work

1955 • 0 citations