Role of Placenta in Preeclampsia

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

The Pathology of the Human Placenta

1967 • 2,145 citations

Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis

2000 • 1,545 citations

Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress

2000 • 1,009 citations

Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

1997 • 920 citations

The role of the spiral arteries in the pathogenesis of pre-eclampsia.

1970 • 800 citations

Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial

1999 • 782 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Oxidative Stress in the Pathogenesis of Preeclampsia

1999 • 673 citations

Low-Dose Aspirin to Prevent Preeclampsia in Women at High Risk

1998 • 652 citations

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome

2002 • 637 citations

Integrin switching regulates normal trophoblast invasion

1994 • 580 citations

Fetal umbilical artery flow velocity waveforms and placental resistance: clinical significance

1985 • 565 citations

Oxygen and placental villous development: Origins of fetal hypoxia

1997 • 563 citations

Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.

1996 • 560 citations

Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts.

1993 • 552 citations

Prevention of Preeclampsia with Low-Dose Aspirin in Healthy, Nulliparous Pregnant Women

1993 • 528 citations

Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation

2002 • 510 citations

Placental Debris, Oxidative Stress and Pre-eclampsia

2000 • 498 citations

Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre‐eclamptic pregnancies

1998 • 492 citations

Severe preeclampsia-eclampsia in young primigravid women: Subsequent pregnancy outcome and remote prognosis

1986 • 406 citations

Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia.

1997 • 402 citations

Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta

1998 • 399 citations

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans

2000 • 397 citations

Mechanism of control of trophoblast invasion in situ

1991 • 374 citations

Oxygen and Placental Development During the First Trimester: Implications for the Pathophysiology of Pre-eclampsia

2000 • 372 citations

Inhibition of TGF-β3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies

1999 • 363 citations

Preeclampsia Is Associated with Widespread Apoptosis of Placental Cytotrophoblasts within the Uterine Wall

1999 • 347 citations

Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast

1997 • 331 citations

Expression of Inflammatory Cytokines in Placentas from Women with Preeclampsia¹

2001 • 326 citations

Macrophage-Induced Apoptosis Limits Endovascular Trophoblast Invasion in the Uterine Wall of Preeclamptic Women

2001 • 295 citations

Localization of VEGF and expression of its receptors flit and KDR in human placenta throughout pregnancy

1996 • 285 citations

Increased placental apoptosis in pregnancies complicated by preeclampsia

2001 • 280 citations

Activin A and inhibin A as possible endocrine markers for pre-eclampsia

1997 • 277 citations

Invasive Cytotrophoblasts Manifest Evidence of Oxidative Stress in Preeclampsia

2000 • 272 citations

Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia

2000 • 256 citations

Colocalisation of Vascular Endothelial Growth Factor and Its Flt-1 Receptor in Human Placenta

1995 • 254 citations

Nitrotyrosine Residues in Placenta

1996 • 253 citations

Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1

1994 • 246 citations

Mechanisms of placental invasion of the uterus and their control

1992 • 242 citations

THE ULTRASTRUCTURE OF THE ARTERIAL SUPPLY OF THE HUMAN PLACENTA IN PREGNANCY COMPLICATED BY FETAL GROWTH RETARDATION

1976 • 233 citations

Placental isoprostane is significantly increased in preeclampsia

2000 • 232 citations

Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies

2001 • 230 citations

Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia

2001 • 230 citations

Maternal circulation in the first-trimester human placenta—Myth or reality?

1997 • 227 citations

The action of nitric oxide in the perfused human fetal-placental circulation

1991 • 223 citations

Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro.

1999 • 211 citations

Immunohistochemical localization of nitric oxide synthase in the human placenta

1993 • 205 citations

Human cytotrophoblast invasion

1993 • 203 citations

Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre‐eclampsia

1999 • 192 citations

Localisation of Placenta Growth Factor (PlGF) in Human Term Placenta

1996 • 189 citations

The Localization and Distribution of Corticotropin-Releasing Hormone in the Human Placenta and Fetal Membranes throughout Gestation*

1991 • 181 citations

Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies

1997 • 181 citations

Nutrition of the Human Fetus during the First Trimester—A Review

2001 • 180 citations

Control of vascular resistance in the human placenta

1992 • 169 citations

Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia

2000 • 167 citations

Role of the IGF system in trophoblast invasion and pre-eclampsia

1999 • 166 citations

Downregulation of Placental Syncytin Expression and Abnormal Protein Localization in Pre-eclampsia

2001 • 165 citations

Prediction of preeclampsia

1999 • 162 citations

Selective Overexpression of the Hypoxia-Inducible Transcription Factor, HIF-2α, in Placentas from Women with Preeclampsia1

2001 • 153 citations

VEGF mRNA levels in placentae from pregnancies complicated by pre‐eclampsia

1996 • 152 citations

Syncytin, a novel human endogenous retroviral gene in human placenta: Evidence for its dysregulation in preeclampsia and HELLP syndrome

2002 • 149 citations

Hemeoxygenase expression in human placenta and placental bed implies a role in regulation of trophoblast invasion and placental function

2000 • 147 citations

Corticotropin-releasing hormone-induced vasodilatation in the human fetal-placental circulation: involvement of the nitric oxide-cyclic guanosine 3',5'-monophosphate-mediated pathway.

1995 • 145 citations

Protein Carbonyls in Decidua and Placenta of Pre-eclamptic Women as Markers for Oxidative Stress

2001 • 141 citations

Role of peroxynitrite in altered fetal-placental vascular reactivity in diabetes or preeclampsia

2000 • 140 citations

The Regulation and Localization of Angiopoietin-1, -2, and Their Receptor Tie2 in Normal and Pathologic Human Placentae

2001 • 129 citations

Constitutive calcium-dependent isoform of nitric oxide synthase in the human placental villous vascular tree

1993 • 120 citations

Heme oxygenase expression in human placenta and placental bed: reduced expression of placenta endothelial HO‐2 in preeclampsia and fetal growth restriction

2001 • 118 citations

Increased Nitrotyrosine in the Diabetic Placenta: Evidence for oxidative stress

1998 • 105 citations

Corticotropin-releasing hormone-induced vasodilatation in the human fetal placental circulation.

1994 • 105 citations

Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction

1996 • 104 citations

Oxidative stress in the pathogenesis of preeclampsia.

1999 • 101 citations

Placental 11β-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies

1998 • 101 citations

Plasma placenta growth factor levels in midtrimester pregnancies

2001 • 101 citations

Invasive cytotrophoblast apoptosis in pre-eclampsia

1999 • 98 citations

Plasma Membrane-Associated pY397FAK Is a Marker of Cytotrophoblast Invasion in Vivo and in Vitro

2001 • 94 citations

Nitric oxide in the uteroplacental, fetoplacental, and peripheral circulations in preeclampsia

1999 • 93 citations

Decreased maternal serum placenta growth factor in early second trimester and preeclampsia

2001 • 91 citations

Prostaglandin production and stimulation by angiotensin II in the isolated perfused human placental cotyledon

1985 • 87 citations

Possible Activation of the Renin-Angiotensin System in the Feto-Placental Unit in Preeclampsia

2002 • 83 citations

In-vivo measurement of intrauterine gases and acid–base values early in human pregnancy

1999 • 82 citations

Lipid peroxide and vitamin E patterns in pregnant women with different types of hypertension in pregnancy

1998 • 77 citations

Interaction of interstitial trophoblast with placental bed capillaries and venules of normotensive and pre-eclamptic pregnancies

1998 • 76 citations

The effects of the components of the renin-angiotensin system on the isolated perfused human placental cotyledon

1984 • 75 citations

Hepatocyte Growth Factor Stimulates Trophoblast Invasion: A Potential Mechanism for Abnormal Placentation in Preeclampsia1

1999 • 71 citations

The upregulation of angiotensin II receptor AT1 in human preeclamptic placenta

2001 • 70 citations

First-trimester maternal serum levels of placenta growth factor as predictor of preeclampsia and fetal growth restriction

2001 • 69 citations

A regulatory role for neurokinin B in placental physiology and pre-eclampsia

2001 • 68 citations

The actions of prostaglandins and their interactions with angiotensin II in the isolated perfused human placental cotyledon

1986 • 67 citations

Enhanced Protein Levels of Protein Thiol/Disulphide Oxidoreductases in Placentae from Pre-eclamptic subjects

2001 • 63 citations

Angiotensin II (AT1) vascular binding sites in human placentae from normal-term, preeclamptic and growth retarded pregnancies.

1994 • 62 citations

Activin A and activin receptors in gestational tissue from preeclamptic pregnancies

2001 • 61 citations

<scp>l</scp>-Arginine Transport by the Microvillous Plasma Membrane of the Syncytiotrophoblast from Human Placenta in Relation to Nitric Oxide Production: Effects of Gestation, Preeclampsia, and Intrauterine Growth Restriction

2002 • 57 citations

Expression of the Heme Oxygenase-Carbon Monoxide Signalling System in Human Placenta

2000 • 57 citations

Vasodilator Effects of Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin Gene-Related Peptide in the Human Fetal-Placental Circulation

1994 • 56 citations

Placenta growth factor is not an early marker for the development of severe preeclampsia

2001 • 56 citations

8-Iso-Prostaglandin F _2α Reduces Trophoblast Invasion and Matrix Metalloproteinase Activity

2000 • 56 citations

Increased placental antifibrinolytic potential and fibrin deposits in pregnancy-induced hypertension and preeclampsia.

1996 • 56 citations

Placental nitric oxide synthase (NOS) activity and nitric oxide (NO) production in normal pregnancy, pre-eclampsia and eclampsia

2001 • 53 citations

Reactivities to serotonin and histamine in umbilical and placental vessels during the third trimester after normotensive pregnancies and pregnancies complicated by preeclampsia

1999 • 51 citations

Expression and Localization of Heme Oxygenase in Human Placental Villi

2000 • 48 citations

Localization and Characterization of Urocortin during Human Pregnancy

2000 • 47 citations

The comparative effects of big endothelin-1, endothelin-1, and endothelin-3 in the human fetal-placental circulation

1992 • 43 citations

Connexins and E-cadherin are differentially expressed during trophoblast invasion and placenta differentiation in the rat

1996 • 42 citations

Effect of Adrenomedullin on Placental Arteries in Normal and Preeclamptic Pregnancies

2001 • 42 citations

VEGF mRNA is unaltered in decidual and placental tissues in preeclampsia at delivery

2001 • 39 citations

Identification and characterization of a corticotrophin-releasing hormone receptor in human placenta

1995 • 38 citations

Nitrotyrosine Immunostaining Correlates with Increased Extracellular Matrix: Evidence of Postplacental Hypoxia

2001 • 34 citations

Immunohistochemical adrenomedullin expression is decreased in the placenta from pregnancies with pre‐eclampsia

2000 • 33 citations

Placental expression of syndecan 1 is diminished in preeclampsia

2000 • 33 citations

Endothelin-1-induced vasoconstriction is not mediated by thromboxane release and action in the human fetal-placental circulation

1991 • 33 citations

Regulation of Human Cytotrophoblast Morphogenesis by Hepatocyte Growth Factor/Scatter Factor1

2001 • 30 citations

Purification and Characterization of a Complex from Placental Syncytiotrophoblast Microvillous Membranes which Inhibits the Proliferation of Human Umbilical Vein Endothelial Cells

1999 • 26 citations

Comparative Study of the Calcium Adenosine Triphosphatase of Basal Membranes of Human Placental Trophoblasts from Normotensive and Preeclamptic Pregnant Women

2001 • 25 citations

Downregulation of a mitogen-activated protein kinase signaling pathway in the placentas of women with preeclampsia

2000 • 24 citations

Pre-eclampsia does not Change the Adhesion Molecule Status in the Placental Bed

2000 • 24 citations

Trophoblast Apoptosis and Placental Development—A Workshop Report

2000 • 24 citations

Serum and Placental Lipid Peroxides in Chronic Hypertension During Pregnancy with and without Superimposed Preeclampsia

1999 • 23 citations

Altered gene expression of endothelin-A and endothelin-B receptors, but not endothelin-1, in myometrium and placenta from pregnancies complicated by preeclampsia

2000 • 23 citations

Thromboxane A2 Limits Differentiation and Enhances Apoptosis of Cultured Human Trophoblasts

2001 • 23 citations

The action of two natriuretic peptides (atrial natriuretic peptide and brain natriuretic peptide) in the human placental vasculature

1995 • 22 citations

Processing of Procorticotropin-Releasing Hormone (Pro-CRH): Molecular Forms of CRH in Normal and Preeclamptic Pregnancy¹

2000 • 22 citations

The Imbalance of Plasminogen Activators and Inhibitor in Preeclampsia

1996 • 22 citations

Decreased very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acid expression in placentas from preeclamptic pregnancies

1996 • 22 citations

Vasoactive Effects of 8-Epi-Prostaglandin F2αin Isolated Human Placental Conduit and Resistance Blood Vessels In Vitro

2001 • 19 citations

Inhibin Expression In Normal And Pre-Eclamptic Placental Tissue

2000 • 19 citations

Intervillous circulation in the first trimester: the phantom of the color Doppler obstetric opera

1996 • 18 citations

Superoxide dismutase activity in normal and preeclamptic placentas.

1998 • 16 citations

Apoptosis: Molecular Control of Placental Function—A Workshop Report

2001 • 13 citations

Selective Vasodilator Effects of Atrial Natriuretic Peptide in the Human Placental Vasculature

1995 • 12 citations

Increase of segments of elastic-type blood vessel walls in fetal placental stem villi during pre-eclampsia at term

1999 • 11 citations

INHIBIN A SERUM LEVELS IN PROTEINURIC AND NONPROTEINURIC PREGNANCY-INDUCED HYPERTENSION: EVIDENCE FOR PLACENTAL INVOLVEMENT IN GESTATIONAL HYPERTENSION?

2000 • 10 citations

[Lipid and protein peroxidation process and catalase activity in pre-eclamptic placenta].

1998 • 8 citations

Histochemical Evaluation of Placental Dipeptidyl Peptidase IV (CD26) in Pre‐eclampsia: Enzyme Activity in Villous Trophoblast Indicates an Enhanced Likelihood of Gestational Hypertensive Disorders

1997 • 5 citations

In vitro effect of bioactive natriuretic peptides on perfusion pressure in placentas from normal and pre-eclamptic pregnancies

1999 • 5 citations

Relative Abundance of Placental Pro-Atrial Natriuretic Factor mRNA in Normal Pregnancy and Pre-Eclampsia

2000 • 5 citations

Use of Doppler ultrasound in the high-risk pregnancy.

1990 • 3 citations

Interaction of angiotensin II and brain natriuretic peptide in the placentas of normal and diabetic women

1995 • 2 citations

The physiological changes in the vascular supply of the human palcenta - a scanning and transmission electron microscopy study [proceedings].

1976 • 1 citations