Role of the CD40 and CD95 (APO‐1/Fas) antigens in the apoptosis of human B‐cell malignancies

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

Fas ligation induces apoptosis of CD40-activated human B lymphocytes.

1995 • 402 citations

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.

1992 • 369 citations

Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression.

1992 • 366 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

Inhibition of human B-cell lymphoma growth by CD40 stimulation

1994 • 232 citations

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

1995 • 224 citations

Enhanced and accelerated lymphoproliferation in Fas-null mice.

1996 • 211 citations

Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.

1991 • 203 citations

A novel function of CD40: induction of cell death in transformed cells.

1996 • 202 citations

Local Fas/APO‐1 (CD95) ligand‐mediated tumor cell killing in vivo

1995 • 201 citations

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.

1995 • 194 citations

Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.

1994 • 182 citations

APO‐1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl‐2 oncogene expression

1993 • 178 citations

Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells.

1994 • 162 citations

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.

1991 • 139 citations

Myeloma cells express Fas antigen/APO-1 (CD95) but only some are sensitive to anti-Fas antibody resulting in apoptosis

1995 • 138 citations

APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

1993 • 131 citations

Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B- lineage non-Hodgkin's lymphoma cells

1990 • 129 citations

Human B cell precursors proliferate and express CD23 after CD40 ligation.

1993 • 123 citations

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

1993 • 107 citations

Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia.

1995 • 102 citations

Functional Consequences of APO-1/Fas (CD95) Antigen Expression by Normal and Neoplastic Hematopoietic Cells

1995 • 98 citations

Expression and function of Fas (APO-1/CD95) in patient myeloma cells and myeloma cell lines

1995 • 88 citations

The CD40 Antigen and Its Ligand

1994 • 82 citations

Flow cytometric detection of the mitochondrial BCL‐2 protein in normal and neoplastic human lymphoid cells

1992 • 81 citations

Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program.

1995 • 72 citations

Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas.

1994 • 69 citations

Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease.

1996 • 68 citations

Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4

1994 • 49 citations

CD40 expression and function in murine B cell ontogeny

1996 • 26 citations

Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B- lineage non-Hodgkin's lymphoma cells

1990 • 18 citations

APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

1993 • 12 citations

Follicular lymphomas can be induced to present alloantigen efficiently: A conceptual model to improve their tumor immunogenicity

1995 • 8 citations

Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4

1994 • 7 citations

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

1993 • 3 citations