Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice

Ionic channels of excitable membranes

1985 • 7,199 citations

The Intrinsic Electrophysiological Properties of Mammalian Neurons: Insights into Central Nervous System Function

1988 • 2,304 citations

Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.

1980 • 1,759 citations

The Ionic Channels in Excitable Membranes

1975 • 1,096 citations

Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.

1980 • 1,043 citations

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes.

1993 • 685 citations

Persistent Sodium Current in Mammalian Central Neurons

1996 • 640 citations

Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons

1997 • 571 citations

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

1989 • 467 citations

A voltage-dependent persistent sodium current in mammalian hippocampal neurons.

1990 • 377 citations

Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.

1989 • 356 citations

Sodium channel α-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system

1997 • 330 citations

Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

1995 • 313 citations

The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker

1991 • 308 citations

Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex

1993 • 303 citations

A novel, abundant sodium channel expressed in neurons and glia

1995 • 230 citations

Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis

1991 • 205 citations

A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axon

1991 • 202 citations

The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits

1994 • 200 citations

Two modes of gating during late Na+ channel currents in frog sartorius muscle.

1986 • 182 citations

Ligand- and voltage-gated ion channels

1995 • 171 citations

Restoration of inactivation and block of open sodium channels by an inactivation gate peptide

1994 • 165 citations

Na+ currents that fail to inactivate

1993 • 160 citations

Alternative Splicing of the Sodium Channel SCN8A Predicts a Truncated Two-domain Protein in Fetal Brain and Non-neuronal Cells

1997 • 152 citations

Mutation Detection in the and Alleles of the Sodium Channel

1996 • 143 citations

A Missense Mutation in the Sodium Channel Scn8a Is Responsible for Cerebellar Ataxia in the Mouse Mutantjolting

1996 • 131 citations

Morphological and physiological differentiation of Purkinje neurons in cultures of rat cerebellum

1987 • 120 citations

Sodium channel mRNAs I, II and III in the CNS: cell-specific expression

1994 • 111 citations

Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin.

1996 • 106 citations

Electrophysiological studies of neuromuscular transmission in hereditary ‘motor end‐plate disease’ of the mouse

1971 • 94 citations

Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells

1997 • 93 citations

Different voltage dependence of transient and persistent Na+ currents is compatible with modal-gating hypothesis for sodium channels

1994 • 80 citations

Hereditary motor end-plate disease in the mouse: light and electron microscopic studies.

1970 • 79 citations

Distribution of I, II and III subtypes of voltage-sensitive Na+ channel mRNA in the rat brain

1993 • 63 citations

Differential expression of sodium channel mRNAs in rat peripheral nervous system and innervated tissues

1990 • 54 citations

Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15

1995 • 54 citations

Ion Channel Mutations in Mouse Models of Inherited Neurological Disease

1997 • 36 citations

A CEREBELLAR ABNORMALITY IN THE MOUSE WITH MOTOR END‐PLATE DISEASE

1985 • 31 citations

Neuromuscular transmission in the murine mutants “motor end-plate disease” and “jolting”

1986 • 29 citations

R56865 and flunarizine as Na+-channel blockers in isolated Purkinje neurons of rat cerebellum

1993 • 29 citations

Physiological and biochemical studies on the cerebellar cortex of the murine mutants “jolting” and “motor end-plate disease”

1992 • 26 citations

Cerebellar structure and function in the murine mutant “jolting”

1986 • 23 citations

Pacemaker properties of mammalian Purkinje cells

1979 • 17 citations