Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli

Basic local alignment search tool

1990 • 87,358 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications

1987 • 3,628 citations

Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria

1993 • 1,767 citations

Basement membrane complexes with biological activity

1986 • 1,489 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

TopPred II: an improved software for membrane protein structure predictions

1994 • 954 citations

Convergent evolution of similar enzymatic function on different protein folds: The hexokinase, ribokinase, and galactokinase families of sugar kinases

1993 • 393 citations

Analysis of theEscherichia coligenome. V. DNA sequence of the region from 76.0 to 81.5 minutes

1994 • 387 citations

[23] Progressive alignment and phylogenetic tree construction of protein sequences

1990 • 350 citations

Evolution by acquisition: the case for horizontal gene transfers

1992 • 325 citations

Membrane Proteins: From Sequence to Structure

1994 • 298 citations

Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system

1992 • 259 citations

Compounds Which Serve as the Sole Source of Carbon or Nitrogen for Salmonella typhimurium LT-2

1969 • 236 citations

Using the FASTA Program to Search Protein and DNA Sequence Databases

2003 • 225 citations

Fructose-bisphosphate aldolases: an evolutionary history

1992 • 220 citations

DNA Sequence and Analysis of 136 Kilobases of the Escherichia coli Genome: Organizational Symmetry around the Origin of Replication

1993 • 215 citations

The bacterial phosphotransferase system: new frontiers 30 years later

1994 • 197 citations

The mannose permease of Escherichia coli consists of three different proteins. Amino acid sequence and function in sugar transport, sugar phosphorylation, and penetration of phage lambda DNA.

1987 • 178 citations

Analysis of theEscherichia coligenome VI: DNA sequence of the region from 92.8 through 100 minutes

1995 • 154 citations

Opine catabolism and conjugal transfer of the nopaline Ti plasmid pTiC58 are coordinately regulated by a single repressor.

1992 • 152 citations

Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon

1990 • 147 citations

Characterization of the lactose-specific enzymes of the phosphotransferase system in Lactococcus lactis.

1990 • 138 citations

Enzymes II of the phospho enol pyruvate-dependent phosphotransferase systems: Their structure and function in carbohydrate transport

1994 • 135 citations

Analysis of theEscherichia coligenome. III. DNA sequence of the region from 87.2 to 89.2 minutes

1993 • 129 citations

Nucleotide sequence, transcriptional analysis, and expression of genes encoded within the form I CO2 fixation operon of Rhodobacter sphaeroides

1991 • 121 citations

Using the FASTA Program to Search Protein and DNA Sequence Databases

1994 • 119 citations

Molecular cloning and nucleotide sequence of the HU-1 gene of Escherichia coli

1985 • 114 citations

Identification, molecular cloning and sequence analysis of a gene cluster encoding the Class II fructose 1,6‐bisphosphate aldolase, 3‐phosphoglycerate kinase and a putative second glyceraldehyde 3‐phosphate dehydrogenase of Escherichia coli

1989 • 108 citations

Sequence of the nagBACD operon in Escherichia coli K12 and pattern of transcription within the nag regulon

1989 • 99 citations

Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans

1992 • 88 citations

Repression and catabolite repression of the lactose operon of Staphylococcus aureus

1990 • 88 citations

Mannose permease of Escherichia coli

1989 • 83 citations

Nucleotide sequences of the Escherichia coli nagE and nagB genes: the structural genes for the N-acetylglucosamine transport protein of the bacterial phosphoenolpyruvate: sugar phosphotrans-ferase system and for glucosamine-6-phosphate deaminase

1988 • 81 citations

The Mechanism of Action of Aldolases

1968 • 80 citations

Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology

1995 • 80 citations

Coordinated regulation of amino sugar-synthesizing and -degrading enzymes in Escherichia coli K-12

1993 • 78 citations

Identification, expression, and deduced primary structure of transketolase and other enzymes encoded within the form II CO2 fixation operon of Rhodobacter sphaeroides.

1991 • 76 citations

Systematic sequencing of theEscherichia coligenome: analysis of the 2.4–4.1 min (110,917–193,643 bp) region

1994 • 74 citations

Complete sequence and transcriptional analysis of the spo0F region of the Bacillus subtilis chromosome

1988 • 74 citations

Analysis of the gluconate (gnt) operon of Bacillus subtilis

1991 • 73 citations

Lactose metabolism by Staphylococcus aureus: characterization of lacABCD, the structural genes of the tagatose 6-phosphate pathway

1991 • 72 citations

Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli

1988 • 71 citations

Cysteine phosphorylation of the glucose transporter of Escherichia coli

1993 • 71 citations

Molecular cloning, primary structure and disruption of the structural gene of aldolase from Saccharomyces cerevisiae

1989 • 65 citations

Cloning, sequence analysis and over-expression of the gene for the class II fructose 1,6-bisphosphate aldolase of Escherichia coli

1989 • 65 citations

Mannitol-specific enzyme II of the bacterial phosphotransferase system. II. Reconstitution of vectorial transphosphorylation in phospholipid vesicles.

1983 • 60 citations

The mannose transporter of Escherichia coli. Structure and function of the IIABMan subunit.

1993 • 57 citations

Glucose-specific permease of the bacterial phosphotransferase system: phosphorylation and oligomeric structure of the glucose-specific IIGlc-IIIGlc complex of Salmonella typhimurium

1986 • 57 citations

Minireview

1994 • 55 citations

Molecular cloning, nucleotide sequence and fine‐structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose‐1,6‐biphosphate aldolase to class I and class II aldolases

1989 • 55 citations

The primary structure of the DeoR represser fromEscherichia coliK-12

1985 • 55 citations

Analysis of mutations affecting the dissimilation of galactitol (dulcitol) in Escherichia coli K12

1977 • 53 citations

The nucleotide sequence ofEscherichia coligenes for L-fucose dissimilation

1989 • 51 citations

31phospho-NMR demonstration of phosphocysteine as a catalytic intermediate on the Escherichia coli phosphotransferase system EIIMtl.

1991 • 50 citations

Identification of zinc‐binding ligands in the Class II fructose‐ 1,6‐bisphosphate aldolase of Escherichia coli

1993 • 48 citations

Substrate specificity and kinetic characterization of sugar uptake and phosphorylation, catalyzed by the mannose enzyme II of the phosphotransferase system in Salmonella typhimurium.

1980 • 48 citations

Lysines 72, 80 and 213 and aspartic acid 210 of the Lactococcus lactis LacR repressor are involved in the response to the inducer tagatose-6-phosphate leading to induction of lac operon expression

1993 • 47 citations

Novel phosphotransferase system genes revealed by bacterial genome analysis - a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system

1995 • 45 citations

Molecular cloning and analysis of the NAG1 cDNA coding for glucosamine-6-phosphate deaminase from Candida albicans

1993 • 43 citations

Glucosamine-6-phosphate synthase from Escherichia coli yields two proteins upon limited proteolysis: Identification of the glutamine amidohydrolase and 2R ketose/aldose isomerase-bearing domains based on their biochemical properties

1991 • 43 citations

Sequence of the sor-operon for l-sorbose utilization from Klebsiella pneumoniae KAY2026

1994 • 42 citations

Novel phosphotransferase system genes revealed by bacterial genome analysis: Unique, putative fructose‐ and glucoside‐specific systems

1994 • 42 citations

Sequence of thefruBgene ofEscherichia coliencoding the diphosphoryl transfer protein (DTP) of the phosphoenolpyruvate: sugar phosphotransferase system

1994 • 40 citations

Evolutionary relationships among the permease proteins of the bacterial phosphoenolpyruvate: Sugar phosphotransferase system. Construction of phylogenetic trees and possible relatedness to proteins of eukaryotic mitochondria

1991 • 33 citations

Molecular evidence for the presence of a developmental gene in the lowest animals: identification of a homeobox-like gene in the marine sponge Geodia cydonium

1994 • 32 citations

Expression, purification, and kinetic characterization of the mannitol transport domain of the phosphoenolpyruvate-dependent mannitol phosphotransferase system of Escherichia coli. Kinetic evidence that the E. coli mannitol transport protein is a functional dimer.

1994 • 31 citations

Fructose catabolism in Xanthomonas campestris pv. campestris. Sequence of the PTS operon, characterization of the fructose-specific enzymes.

1991 • 29 citations

Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli

1995 • 28 citations

A complete, yet flexible, system for DNA/protein sequence analysis using VAX/VMS computers

1988 • 27 citations

XI. Yeast sequencing reports. Sequence of a 28·6 kb region of yeast chromosome XI includes theFBA1 andTOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins

1994 • 27 citations

Function of the Duplicated IIB Domain and Oligomeric Structure of the Fructose Permease of Escherichia coli

1996 • 26 citations

Group Translocation of Glucose and Other Carbohydrates by the Bacterial Phosphotransferase System

1992 • 25 citations

Physiological effects of the fructose-1,6-diphosphate aldolase ts8 mutation on stable RNA synthesis in Escherichia coli

1991 • 24 citations

The Mannose Transporter ofEscherichia coli K12: Oligomeric Structure, and Function of Two Conserved Cysteines

1994 • 23 citations

Large inversion in Escherichia coli K-12 1485IN between inversely oriented IS3 elements near lac and cdd.

1991 • 23 citations

Identification of two cysteine residues forming a pair of vicinal thiols in glucosamine-6-phosphate deaminase from Escherichia coli and a study of their functional role by site-directed mutagenesis

1992 • 21 citations

Molecular analysis of the phosphoenolpyruvate-dependent l-sorbose: phosphotransferase system from Klebsiella pneumoniae and of its multidomain structure

1995 • 20 citations

The Escherichia coli ts8 mutation is an allele of fda, the gene encoding fructose-1,6-diphosphate aldolase

1991 • 20 citations

The amino acid sequence of a Bacillus subtilis phosphoprotein that matches an orfY‐tsr coding sequence

1992 • 16 citations

Molecular cloning and nucleotide sequencing of Schizosaccharomyces pombe homologue of the class II fructose-1,6-bisphosphate aldolase gene

1994 • 15 citations

TheEscherichia coli mannitol permease as a model for transport via the bacterial phosphotransferase system

1993 • 13 citations

Multifunctional Proteins: Catalytic/Structural and Regulatory

2019 • 13 citations

Interrelationships between protein phosphorylation and oligomerization in transport and chemotaxis via the Escherichia coli mannitol phosphotransferase system

1992 • 12 citations

Progressive Multiple Alignment of Protein Sequences and the Construction of Phylogenetic Trees

1994 • 12 citations

Nucleotide sequence of theglpRgene encoding the repressor for the glycerol-3-phosphate regulon ofEscherichia coliK12

1988 • 9 citations