Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered

The Fas Death Factor

1995 • 4,070 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Molecular Basis of T Cell Inactivation by CTLA-4

1998 • 678 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells

1997 • 405 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

Is CTLA-4 a master switch for peripheral T cell tolerance?

1997 • 284 citations

IL-4-deficient Balb/c mice resist infection with Leishmania major.

1996 • 273 citations

Cutting Edge: Lymphoproliferative Disease in the Absence of CTLA-4 Is Not T Cell Autonomous

1999 • 236 citations

CTLA-4 gene polymorphism is associated with predisposition to coeliac disease

1998 • 220 citations

The Role of CTLA‐4 in the Regulation and Initiation of T‐Cell Responses

1996 • 208 citations

An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it

1980 • 190 citations

Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission

1993 • 189 citations

Lymphoproliferative Disorder in CTLA-4 Knockout Mice Is Characterized by CD28-Regulated Activation of Th2 Responses

1999 • 182 citations

CTLA-4 Regulates Tolerance Induction and T Cell Differentiation In Vivo

1998 • 174 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70

1997 • 153 citations

CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.

1996 • 149 citations

The Role of CTLA-4 in Regulating Th2 Differentiation

1999 • 148 citations

Association of CTLA-4 Gene A-G Polymorphism (IDDM12 Locus) With Acute-Onset and Insulin-Depleted IDDM as Well as Autoimmune Thyroid Disease (Graves' Disease and Hashimoto's Thyroiditis) in the Japanese Population

1998 • 147 citations

Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani

1998 • 135 citations

The antigen dose determines T helper subset development by regulation of CD40 ligand

2000 • 134 citations

Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice.

1998 • 129 citations

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

1996 • 124 citations

Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production.

1999 • 122 citations

CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion

1997 • 120 citations

Immune responses in the absence of costimulation: viruses know the trick.

1998 • 119 citations

Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells

1998 • 115 citations

Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade

1997 • 113 citations

Cutting Edge Commentary: Immune Responses in the Absence of Costimulation: Viruses Know the Trick

1998 • 99 citations

Anti-TGF-β Treatment Promotes Rapid Healing ofLeishmania majorInfection in Mice by Enhancing In Vivo Nitric Oxide Production

1999 • 96 citations

CTLA‐4, a Negative Regulator of T‐Lymphocyte Activation

1996 • 91 citations

Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells

1993 • 87 citations

Genetic association of Ctla-4 to myasthenia gravis with thymoma

1998 • 86 citations

Normal Responsiveness of CTLA-4-Deficient Anti-Viral Cytotoxic T Cells

1998 • 75 citations

Polarization of Naive CD4+ T Cells Toward the Th1 Subset by CTLA-4 Costimulation

2000 • 70 citations

Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host **This article was accepted for publication on 1 October 1996.

1997 • 68 citations

B7–CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge

1998 • 51 citations

CTLA4 (CD152) modulates the Th subset response and alters the course of experimentalLeishmania major infection

1998 • 37 citations