Genetics and the common cancers

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

1995 • 8,575 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

Risks of cancer in BRCA1-mutation carriers

1994 • 1,865 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Linkage disequilibrium in the human genome

2001 • 1,779 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Cancer Risks in BRCA2 Mutation Carriers

1999 • 1,477 citations

Linkage strategies for genetically complex traits. I. Multilocus models.

1990 • 1,335 citations

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

1993 • 1,269 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

TOXIC-SHOCK SYNDROME NOT ASSOCIATED WITH MENSTRUATION

1982 • 1,169 citations

Systematic Population-Based Assessment of Cancer Risk in First-Degree Relatives of Cancer Probands

1994 • 1,029 citations

Mendelian Inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive, and X-Linked Phenotypes.

1967 • 1,002 citations

Genetic analysis of breast cancer in the cancer and steroid hormone study.

1991 • 915 citations

Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients With Early-Onset Breast Cancer

1999 • 866 citations

Mendelian inheritance of familial prostate cancer.

1992 • 803 citations

Family history and the risk of prostate cancer

1990 • 729 citations

Cancer epidemiology in the last century and the next decade

2001 • 675 citations

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

2000 • 671 citations

A systematic review of genetic polymorphisms and breast cancer risk.

1999 • 543 citations

Assignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22

1992 • 531 citations

Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families.

1988 • 510 citations

Number of melanocytic nevi as a major risk factor for malignant melanoma

1987 • 507 citations

ROLE OF N-ACETYLTRANSFERASE PHENOTYPES IN BLADDER CARCINOGENESIS: A PHARMACOGENETIC EPIDEMIOLOGICAL APPROACH TO BLADDER CANCER

1982 • 501 citations

Common Inheritance of Susceptibility to Colonic Adenomatous Polyps and Associated Colorectal Cancers

1988 • 472 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

Cancer genetics

2001 • 421 citations

Lung cancer among Chinese women

1987 • 418 citations

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1984 • 386 citations

Cancer Risk in Relatives of Patients with Common Colorectal Cancer

1993 • 374 citations

Li-Fraumeni syndrome – a molecular and clinical review

1997 • 362 citations

Family history and the risk of stomach and colorectal cancer

1992 • 349 citations

Cigarette Smoking, N-Acetyltransferase 2 Genetic Polymorphisms, and Breast Cancer Risk

1996 • 334 citations

Pigmentary Traits, Ethnic Origin, Benign Nevi, and Family History as Risk Factors for Cutaneous Malignant Melanoma<xref ref-type="fn" rid="FN2">2</xref>

1984 • 334 citations

Family studies in cancer of the colon and rectum

1976 • 327 citations

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

1990 • 304 citations

Familial Aggregation of Lung Cancer in Humans<xref ref-type="fn" rid="fn1">2</xref>

1963 • 295 citations

High constant incidence in twins and other relatives of women with breast cancer

2000 • 294 citations

An Association between the Risk of Cancer and Mutations in the HRAS1 Minisatellite Locus

1993 • 290 citations

Cancer Risks in A-T Heterozygotes

1994 • 287 citations

Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours

2000 • 272 citations

Evidence for Mendelian Inheritance in the Pathogenesis of Lung Cancer

1990 • 263 citations

Determinants of Ovarian Cancer Risk. I. Reproductive Experiences and Family History<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 262 citations

Increased Familial Risk for Lung Cancer

1986 • 255 citations

AN EPIDEMIOLOGIC STUDY OF EPITHELIAL CARCINOMA OF THE OVARY

1981 • 253 citations

Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA regions

1990 • 252 citations

Molecular epidemiology: recent advances and future directions

2000 • 237 citations

Polymorphisms and colorectal tumor risk

2001 • 231 citations

Dominant Inheritance of Adenomatous Colonic Polyps and Colorectal Cancer

1985 • 231 citations

Mapping Genes That Underlie Ethnic Differences in Disease Risk: Methods for Detecting Linkage in Admixed Populations, by Conditioning on Parental Admixture

1998 • 229 citations

Familial Patterns of Prostate Cancer: A Case-Control Analysis

1991 • 225 citations

Family History and the Risk of Breast Cancer

1985 • 222 citations

Common acquired naevi and the risk of malignant melanoma

1985 • 222 citations

Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class 1 sib-pair analysis

1992 • 216 citations

Inheritance of Cancer of the Stomach and Large Intestine in Man2

1960 • 210 citations

Familial occurrence of gastric cancer in the 2-year experience of a population-based registry

1990 • 209 citations

Reported family aggregation of pancreatic cancer within a population-based case-control study in the francophone community in Montreal, Canada

1991 • 197 citations

BREAST CANCER RISK ASSOCIATED WITH PROLIFERATIVE DISEASE, AGE AT FIRST BIRTH, AND A FAMILY HISTORY OF BREAST CANCER1

1987 • 195 citations

Heritability of Cellular Radiosensitivity: A Marker of Low-Penetrance Predisposition Genes in Breast Cancer?

1999 • 195 citations

Environmental Tobacco Smoke, Genetic Susceptibility, and Risk of Lung Cancer in Never-Smoking Women

1999 • 191 citations

The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews

1998 • 189 citations

Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition?

1998 • 171 citations

The Danish case‐control study of cutaneous malignant melanoma. I. Importance of host factors

1988 • 171 citations

Lung cancer in women: the importance of smoking, family history of cancer, and medical history of respiratory disease.

1991 • 168 citations

Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). II. Biomarker studies

1985 • 165 citations

Melanoma genetics: An update with focus on the CDKN2A(p16)/ARF tumor suppressors

2000 • 159 citations

Personal and family history of respiratory disease and lung cancer risk.

1986 • 157 citations

Evaluating genetic association among ovarian, breast, and endometrial cancer: evidence for a breast/ovarian cancer relationship.

1989 • 153 citations

Personal and family history of lung disease as risk factors for adenocarcinoma of the lung

1989 • 152 citations

Dominant genes for colorectal cancer are not rare

1992 • 150 citations

Inherited susceptibility to breast cancer.

1993 • 148 citations

Genetic epidemiology of breast cancer: Segregation analysis of 200 Danish pedigrees

1984 • 143 citations

Family history of colorectal cancer as a risk factor for benign and malignant tumours of the large bowel. A case‐control study

1988 • 142 citations

Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis.

1999 • 141 citations

RISK FACTORS FOR BREAST CANCER: POOLED RESULTS FROM THREE ITALIAN CASE-CONTROL STUDIES

1988 • 137 citations

Model for the incidence of embryonal cancers: application to retinoblastoma.

1978 • 134 citations

Incidence and familial occurrence of colorectal cancer and polyps in a health-care district of Northern Italy

1987 • 129 citations

Genetic Concepts and Neoplasia

1971 • 129 citations

Inherited predisposition to cancer

1990 • 128 citations

Familial papillary carcinoma of the thyroid

1986 • 127 citations

CYP1A1 polymorphisms and lung cancer risk: a meta-analysis

2000 • 127 citations

Cancer mortality in relatives of women with ovarian cancer: The OPCS study

1996 • 126 citations

Sexual factors in the epidemiology of cancer of the prostate

1971 • 126 citations

Breast Cancer in Men: Aspects of Familial Aggregation

1991 • 125 citations

A genetic study of carcinoma of the large intestine.

1958 • 123 citations

FAMILIAL BREAST CANCER IN A POPULATION-BASED SERIES

1986 • 122 citations

The contribution of inherited predisposition to cancer incidence.

1990 • 122 citations

Frequency of familial colorectal cancer

1991 • 117 citations

Principles of Health and Safety in Agriculture

1989 • 117 citations

Cancer mortality in relatives of women with breast cancer: The OPCS study

1996 • 117 citations

A case-control study of male breast cancer.

1988 • 116 citations

Familial factors affecting prostatic cancer risk and plasma sex‐steroid levels

1985 • 114 citations

Some epidemiologic variables in prostatic carcinoma in California

1974 • 114 citations

Genetic Epidemiology of Breast Cancer and Associated Cancers in High-Risk Families. I. Segregation Analysis<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 107 citations

Genomewide Transmission/Disequilibrium Testing—Consideration of the Genotypic Relative Risks at Disease Loci

1997 • 107 citations

FAMILY HISTORY OF BREAST CANCER AS A RISK INDICATOR FOR THE DISEASE

1980 • 106 citations

Breast Cancer Risks in Relatives of Male Breast Cancer Patients

1992 • 106 citations

Interaction of Familial and Hormonal Risk Factors for Breast Cancer

1982 • 105 citations

Epidemiologic study of prostatic cancer: preliminary report.

1977 • 103 citations

Risk factors for cutaneous malignant melanoma in a northern italian population

1987 • 103 citations

Cancer Incidence in Defined Populations

1980 • 100 citations

A Large Kindred With 17q-Linked Breast and Ovarian Cancer: Genetic, Phenotypic, and Genealogical Analysis

1994 • 99 citations

Lung cancer risk associated with cancer in relatives

1991 • 98 citations

Risk factors for renal cell carcinoma in Denmark. I. Role of socioeconomic status, tobacco use, beverages, and family history

1994 • 93 citations

Family incidence of carcinoma of the colon and rectum in north-east Scotland.

1982 • 92 citations

HLA and Susceptibility to Hodgkin's Disease

1983 • 90 citations

Genetic susceptibility to naevi – a twin study

1991 • 88 citations

Melanocytic naevi and melanoma: an epidemiological perspective

1987 • 87 citations

Familial Aggregation of Lung Cancer among Hospital Patients

1963 • 83 citations

Familial and environmental interactions in bladder cancer risk

1985 • 77 citations

There is no such thing as ageing, and cancer is not related to it.

1985 • 77 citations

Clustering of cancer in families of patients with primary lung cancer

1991 • 76 citations

Family history and risk of breast cancer.

1992 • 76 citations

A segregation analysis of testicular cancer based on Norwegian and Swedish families

1997 • 75 citations

Genetic epidemiology of breast cancer in Britain

1991 • 74 citations

RECHERCHES CLINICO-STATISTIQUES ET GÉNÉTIQUES SUR LES NÉOPLASIES DE LA PROSTATE

1956 • 72 citations

Glutathione S-transferase micro1 (GSTM1) status and bladder cancer risk: a meta-analysis

2000 • 68 citations

Family History of Ovarian Cancer Patients: A Case-Control Study

1989 • 68 citations

Segregation and linkage analysis of nine Utah breast cancer pedigrees

1988 • 68 citations

Genetic epidemiology of ovarian cancer: segregation analysis

1991 • 66 citations

Family aggregation of cancer of the prostate in quebec: The tip of the iceberg

1991 • 66 citations

Genetics and smoking-associated cancers. A study of 485 families

1986 • 65 citations

Familial Nonmedullary Thyroid Cancer

1991 • 63 citations

Segregation analysis of hereditary nonpolyposis colorectal cancer

1986 • 62 citations

Cancer incidence among parents of patients with colorectal cancer

1991 • 62 citations

The melbourne colorectal cancer study

1987 • 60 citations

Familial adenomatous polyposis (FAP) and its gene, APC

1999 • 55 citations

Epidemiology of breast cancer in families in Iceland.

1992 • 54 citations

[Familial occurrence of cancer of the colon and the rectum: results of a 3-year case-control survey].

1984 • 51 citations

N-acetyl transferase-2 and bladder cancer risk: A meta-analysis

2000 • 49 citations

Colonic cancer arising in polyposis coli.

1969 • 49 citations

An Ecogenetic Hypothesis for Lung Cancer in Women

1988 • 47 citations

Risk factors for breast cancer according to age at diagnosis in a french case-control study

1990 • 46 citations

Age-Related Factors in Carcinogenesis

1986 • 45 citations

Smoking, Occupation and Family History in Lung Cancer Patients under Fifty Years of Age

1987 • 40 citations

Familiality in breast cancer: a case-control study in a Swedish population

1980 • 39 citations

A genetic epidemiologic investigation of breast cancer in families with bilateral breast cancer. I. Segregation analysis.

1987 • 39 citations

Detecting low penetrance genes in cancer: the way ahead

2000 • 31 citations

A Simple Model for Carcinogenesis of Colorectal Cancers with Microsatellite Instability

1999 • 27 citations

Germline mutation and genome instability

1999 • 27 citations

A Genetic study of hypoalphalipoproteinemia

1984 • 24 citations

Transmission of breast cancer ‐ a controversy resolved

1992 • 24 citations

THE PREVENTION OF CANCER

1934 • 23 citations

Segregation and linkage analysis of breast cancer in the Dutch and Utah families

1986 • 13 citations

Inheritance of nevus number and size in melanoma/DNS kindreds

1992 • 10 citations

Palmar keratoses in family members of individuals with bladder cancer

1990 • 10 citations

Assignment<footref rid="foot01"><sup>1</sup></footref> of the dipeptidyl peptidase III gene (DPP3) to human chromosome 11 band q12→q13.1 by in situ hybridization

2000 • 7 citations

Review : Epidemiological Studies Relating Family History of Lung Cancer to Risk of the Disease

1993 • 5 citations