Prostacyclin biosynthesis in vascular endothelium is not inhibited by cyclic AMP. Studies with 3-isobutyl-1-methylxanthine and forskolin

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

1981 • 1,655 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187

1978 • 715 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

The interaction of cyclic nucleotides and calcium in the control of cellular activity.

1975 • 451 citations

The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3′:5′-cyclic monophosphate in platelets

1971 • 422 citations

Enzymatic conversion of prostaglandin endoperoxide H2 and arachidonic acid to prostacyclin by cultured human endothelial cells.

1978 • 196 citations

Effect of Aspirin on Thrombin-Induced Adherence of Platelets to Cultured Cells from the Blood Vessel Wall

1978 • 184 citations

Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin.

1981 • 155 citations

Role of Ca2+ and cyclic AMP in the regulation of the production of prostacyclin by the vascular endothelium.

1982 • 140 citations

Use of a radioimmunoassay to study thrombin-induced release of PGI2 from cultured endothelium

1979 • 123 citations

Inhibition of prostacyclin by treatment of endothelium with aspirin. Correlation with platelet adherence.

1979 • 114 citations

DIPYRIDAMOLE: A POTENT STIMULATOR OF PROSTACYCLIN (PGI₂) BIOSYNTHESIS

1980 • 90 citations

Phosphodiesterase inhibitors as tools in cyclic nucleotide research: A precautionary comment

1981 • 90 citations

Antibodies which antagonise the effects of prostacyclin

1978 • 70 citations

Evidence that the effects of thrombin on arachidonate metabolism in cultured human endothelial cells are not mediated by a high affinity receptor.

1980 • 53 citations

Prostacyclin and beta-adrenergic catecholamines inhibit arachidonate release and PGI2 synthesis by vascular endothelium

1981 • 50 citations

Xanthines and skeletal muscle: lack of relationship between phosphodiesterase inhibition and increased twitch tension in rat diaphragms.

1980 • 31 citations

Role of the vascular endothelium

1981 • 18 citations

Selective phosphodiesterase inhibition and alterations of cardiac function by alkylated xanthines.

1981 • 7 citations

Inhibition of bradykinin stimulation of renal medullary prostaglandin E2 synthesis by phosphodiesterase inhibitors.

1981 • 2 citations