The folding and stability of titin immunoglobulin-like modules, with implications for the mechanism of elasticity

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

The Physics of Rubber Elasticity

1959 • 3,850 citations

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

1986 • 2,265 citations

Protein Denaturation

1968 • 2,108 citations

Principles of protein structure

1980 • 1,094 citations

Protein stability curves

1987 • 990 citations

The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line.

1988 • 608 citations

Many of the Immunoglobulin Superfamily Domains in Cell Adhesion Molecules and Surface Receptors Belong to a New Structural Set Which is close to That Containing Variable Domains

1994 • 439 citations

Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans

1989 • 368 citations

Towards a molecular understanding of titin.

1992 • 338 citations

Rapid purification of homodimer and heterodimer HIV‐1 reverse transcriptase by metal chelate affinity chromatography

1990 • 333 citations

Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2

1992 • 295 citations

Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin.

1994 • 294 citations

Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2

1993 • 256 citations

Thermodynamic analysis of the folding of the streptococcal protein G IgG-binding domains B1 and B2: why small proteins tend to have high denaturation temperatures

1992 • 250 citations

A regular pattern of two types of 100-residue motif in the sequence of titin

1990 • 244 citations

Does titin regulate the length of muscle thick filaments?

1989 • 240 citations

Stabilization of protein structure by interaction of α-helix dipole with a charged side chain

1988 • 229 citations

Titin and nebulin: protein rulers in muscle?

1994 • 202 citations

Sarcomere-Associated Cytoskeletal Lattices in Striated Muscle

1985 • 169 citations

Visualization of the polarity of isolated titin molecules: a single globular head on a long thin rod as the M band anchoring domain?

1989 • 153 citations

Connectin, an Elastic Protein of Muscle. Identification of “Titin” with Connectin1

1981 • 153 citations

Structure of domain 1 of rat T lymphocyte CD2 antigen

1991 • 142 citations

A survey of interactions made by the giant protein titin

1993 • 141 citations

Histidine residues at the N- and C-termini of .alpha.-helixes: perturbed pKas and protein stability

1992 • 122 citations

Elastic filaments in situ in cardiac muscle: deep-etch replica analysis in combination with selective removal of actin and myosin filaments.

1993 • 118 citations

Connectin, an elastic protein of striated muscle

1994 • 116 citations

Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts.

1993 • 111 citations

Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set

1995 • 108 citations

The globular head domain of titin extends into the center of the sarcomeric m band: cdna cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins

1993 • 105 citations

The pKa values of two histidine residues in human haemoglobin, the Bohr effect, and the dipole moments of α-helices

1985 • 105 citations

Elastic behavior of connectin filaments during thick filament movement in activated skeletal muscle.

1989 • 100 citations

Giant polypeptides of skeletal muscle titin: Sedimentation equilibrium in guanidine hydrochloride

1988 • 86 citations

Immunoglobulin-Type Domains of Titin: Same Fold, Different Stability?

1994 • 82 citations

Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis

1991 • 73 citations

Titin folding energy and elasticity

1993 • 69 citations

Structure and function of titin and nebulin

1995 • 67 citations

Domain interactions and connecting peptides in lens crystallins

1994 • 64 citations

Immunoglobulin‐type domains of titin are stabilized by amino‐terminal extension

1994 • 55 citations

Secondary structure determination by NMR spectroscopy of an immunoglobulin-like domain from the giant muscle protein titin

1995 • 19 citations

Dissecting Titin into Its Structural Motifs: Identification of an .alpha.-Helix Motif near the Titin N-Terminus

1995 • 15 citations

The entropic tension of protein loops

1990 • 14 citations

Domain Structure of the Fib-1 and Fib-2 Regions of Human Fibronectin

1994 • 13 citations