Cryoenzymology of Bacillus cereus .beta.-lactamase II

Stability of Proteins Small Globular Proteins

1979 • 2,139 citations

Novel Method for Detection of β-Lactamases by Using a Chromogenic Cephalosporin Substrate

1972 • 1,857 citations

The structure of β-lactamases

1980 • 1,705 citations

Hydrogen exchange and structural dynamics of proteins and nucleic acids

1983 • 1,329 citations

Analysis of numerical methods for computer simulation of kinetic processes: Development of KINSIM—A flexible, portable system

1983 • 597 citations

Stereoelectronic effects in organic chemistry

1983 • 587 citations

The Metallobiochemistry of Zinc Enzymes

1984 • 308 citations

A simple test for inactivation of an enzyme during assay

1965 • 251 citations

An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides

1984 • 249 citations

Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia

1982 • 234 citations

Spectral-structural correlations in high-spin cobalt(II) complexes

2007 • 218 citations

On the three-dimensional structure and catalytic mechanism of triose phosphate isomerase

1981 • 216 citations

Estimation of Michaelis constant and maximum velocity from the direct linear plot

1978 • 190 citations

The mechanisms of reactions of .beta.-lactam antibiotics

1984 • 189 citations

Protein fluctuations and the thermodynamic uncertainty principle

1984 • 162 citations

Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by x-ray crystallography: a novel class of transition-state analogs for zinc peptidases

1984 • 153 citations

Zinc as a Cofactor for Cephalosporinase from Bacillus cereus 569

1966 • 144 citations

Cobalt(II) as a probe of the structure and function of carbonic anhydrase

1983 • 131 citations

Interaction of Cobalt (II)-Carbonic Anhydrase with Anions^*

1966 • 123 citations

Human Carbonic Anhydrase. Protein Conformation and Metal Ion Binding^*

1965 • 120 citations

Relevance of dielectric constant and solvent hydrophobicity to the organic solvent effect in enzymology.

1978 • 114 citations

Separation, purification and properties of β-lactamase I and β-lactamase II from Bacillus cereus 569/H/9

1974 • 113 citations

Metal cofactor requirement of β-lactamase II

1974 • 111 citations

Enzymology in Aqueous-Organic Cosolvent Binary Mixtures

1972 • 101 citations

The acyl-enzyme mechanism of β-lactamase action. The evidence for class C β-lactamases

1982 • 96 citations

Influence of pH on the kinetics of complex formation between aromatic sulfonamides and human carbonic anhydrase

1970 • 84 citations

Inhibition of the RTEM .beta.-lactamase from Escherichia coli. Interaction of the enzyme with derivatives of olivanic acid

1981 • 70 citations

Elimination of a good leaving group from the 3'-position of a cephalosporin need not be concerted with .beta.-lactam ring opening: TEM-2 .beta.-lactamase-catalyzed hydrolysis of pyridine-2-azo-4'-(N',N'-dimethylaniline) cephalosporin (PADAC) and of cephaloridine

1984 • 66 citations

Magnetic circular dichroic spectra of cobalt(II) substituted metalloenzymes

1975 • 62 citations

beta-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl transfer to specific amino acid acceptors.

1984 • 60 citations

Half-time analysis of the integrated Michaelis equation. Simulation and use of the half-time plot and its direct linear variant in the analysis of some α-chymotrypsin-, papain- and fumarase-catalysed reactions

1982 • 52 citations

Cryospectrokinetic characterization of intermediates in biochemical reactions: carboxypeptidase A.

1984 • 47 citations

Cryokinetic studies of the intermediates in the mechanism of carboxypeptidase A

1983 • 43 citations

Stabilization of a phosphorylase b active conformation by hydrophobic solvents

1978 • 41 citations

A spectroscopic study of metal ion and ligand binding to β-lactamase II

1980 • 37 citations

Identification of histidine residues that act as zinc ligands in β-lactamase II by differential tritium exchange

1979 • 35 citations

The pH-dependence of class B and class C β-lactamases

1983 • 33 citations

Production of a variant of β-lactamase II with selectively decreased cephalosporinase activity by a mutant of Bacillus cereus 569/H/9

1980 • 26 citations

Aldolase Catalysis: Single Base-Mediated Proton Activation

1973 • 25 citations

Active sites of β-lactamases from Bacillus cereus

1980 • 21 citations