Antisense Oligonucleotide Blockade of Tumor Necrosis Factor-α in Two Murine Models of Colitis

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease

1999 • 2,656 citations

A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

1990 • 2,321 citations

Clinicopathologic study of dextran sulfate sodium experimental acute colitis

1998 • 1,955 citations

Interleukin-10

1993 • 1,820 citations

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

1998 • 1,451 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines

1998 • 1,038 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice

1999 • 771 citations

Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice

1994 • 671 citations

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

1997 • 660 citations

Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin

1993 • 540 citations

Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.

1993 • 532 citations

Tumour necrosis factor and Crohn's disease.

1997 • 504 citations

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

1997 • 422 citations

Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.

1987 • 418 citations

Randomised controlled trial of CDP571 antibody to tumour necrosis factor-α in Crohn's disease

1997 • 400 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease

1998 • 386 citations

Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice

1997 • 314 citations

Interferon-gamma (IFN-γ)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice

1999 • 298 citations

Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats.

2001 • 265 citations

IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice.

1998 • 256 citations

Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease

1999 • 255 citations

Antibiotic therapy attenuates colitis in interleukin 10 gene–deficient mice

2000 • 231 citations

IL-12, But Not IFN-γ, Plays a Major Role in Sustaining the Chronic Phase of Colitis in IL-10-Deficient Mice

1998 • 201 citations

An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice.

1997 • 185 citations

Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes.

1996 • 168 citations

Specific type IV phosphodiesterase inhibitor rolipram mitigates experimental colitis in mice.

2000 • 158 citations

Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis

1998 • 154 citations

Cellular distribution of phosphorothioate oligodeoxynucleotides in normal rodent tissues.

1997 • 147 citations

Helicobacter hepaticus-Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation

2001 • 140 citations

Chemically modified oligonucleotides exhibit decreased immune stimulation in mice.

2000 • 131 citations

Second-generation antisense oligonucleotides: structure—activity relationships and the design of improved signal-transduction inhibitors

1996 • 105 citations

Pattern and Kinetics of Cytokine Production Following Administration of Phosphorothioate Oligonucleotides in Mice

1997 • 100 citations

Treatment of ulcerative colitis in the cottontop tamarin using antibody to tumour necrosis factor alpha.

1997 • 97 citations

Chronic Colitis in IL-10^-/-Mice: Insufficient Counter Regulation of a Th1 Response

2000 • 81 citations

Combination therapy of pentoxifylline and TNFα monoclonal antibody in dextran sulphate‐induced mouse colitis

1999 • 73 citations

Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice.

2001 • 69 citations

Spectrum of Cytokine Gene Expression in Intestinal Mucosal Lesions of Crohn’s Disease and Ulcerative Colitis

1998 • 63 citations

Involvement of CD4+ T Cells in the Development of Dextran Sulfate Sodium-Induced Experimental Colitis and Suppressive Effect of IgG on Their Action

1998 • 59 citations

Antiserum to Tumor Necrosis Factor and Failure to Prevent Murine Colitis

1995 • 41 citations

Antitumor necrosis factor therapy in rat chronic granulomatous colitis: critical dose-timing effects on outcome.

1998 • 20 citations

Involvement of luminal bacteria, heat shock protein 60, macrophages and gammadelta T cells in dextran sulfate sodium-induced colitis in rats.

2000 • 18 citations

Antisense Oligonucleotide-based Therapeutics

2003 • 13 citations