Expression and utilization of chymotrypsin-like but not trypsin-like serine protease enzymes by nonspecific T killer cells activated by anti-CD3 monoclonal antibody

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

A glycolipid on the surface of mouse natural killer cells

1980 • 539 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester.

1983 • 353 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

Target-effector interaction in the natural killer (NK) cell system. II. The isolation of NK cells and studies on the mechanism of killing.

1978 • 266 citations

Cloning of a cDNA for a T Cell-Specific Serine Protease from a Cytotoxic T Lymphocyte

1986 • 247 citations

Novel Serine Proteases Encoded by Two Cytotoxic T Lymphocyte-Specific Genes

1986 • 246 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Isolation and characterization of a serine esterase from cytolytic T cell granules

1986 • 177 citations

Target-Effector Interaction in the Natural Killer (NK) Cell System

1978 • 162 citations

The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases.

1980 • 155 citations

Specific release of proteoglycans from human natural killer cells during target lysis

1985 • 146 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

Requirements for T cell activation by OKT3 monoclonal antibody: role of modulation of T3 molecules and interleukin 1.

1985 • 131 citations

A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.

1988 • 130 citations

Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies.

1985 • 126 citations

Effect of rabbit anti-asialo GM1 treatment in vivo or with anti-asialo GM1 plus complement in vitro on cytotoxic T cell activities.

1986 • 102 citations

In Vivo Administration of Anti-CD3 Prevents Malignant Progressor Tumor Growth

1988 • 89 citations

Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro.

1988 • 79 citations

Biochemical and functional properties of serine esterases in acidic cytoplasmic granules of cytotoxic T lymphocytes.

1987 • 70 citations

Induction of perforin and serine esterases in a murine cytotoxic T lymphocyte clone.

1990 • 63 citations

IL-2 induces expression of serine protease enzymes and genes in natural killer and nonspecific T killer cells.

1989 • 53 citations

Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice.

1990 • 48 citations

Antibody-dependent cell-mediated cytotoxicity in humans. III. Effect of protease inhibitors and substrates.

1976 • 48 citations

Age‐related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL‐associated serine esterase genes and the perforin gene in mice

1990 • 46 citations

Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans

1987 • 46 citations

Role of granule proteins in lymphocyte‐mediated killing

1986 • 37 citations

Antibody-Dependent Cell-Mediated Cytotoxicity in Humans

1976 • 34 citations

Murine anti-CD3 monoclonal antibody induces potent cytolytic activity in both T and NK cell populations

1989 • 30 citations

An inhibitor specific for the mouse T‐cell associated serine proteinase 1 (TSP‐1) inhibits the cytolytic potential of cytoplasmic granules but not of intact cytolytic T cells

1989 • 28 citations

Isolation of two cDNA sequences which encode cytotoxic cell proteases

1988 • 25 citations

Transcriptional regulation of two cytotoxk T lymphocyte-specific serine protease gene

1989 • 25 citations

Comparison of cellular immunotherapies and anti-CD3 in the treatment of MCA-38-LD experimental hepatic metastases in C57BL/6 mice.

1990 • 23 citations

Cytotoxic mechanisms of murine lymphokine-activated killer cells: Functional and biochemical characterization of homogeneous populations of spleen LAK cells

1990 • 23 citations

A functional and phenotypic comparison of murine natural killer (NK) cells and lymphokine‐activated killer (LAK) cells

1989 • 17 citations

Granzyme A expression by normal rat natural killer (NK) cells in vivo and by interleukin 2‐activated NK cells in vitro

1989 • 15 citations

Amelioration of experimental lung metastasis in mice by therapy with anti-CD3 monoclonal antibodies

1989 • 13 citations

Evidence for involvement of serine proteases in the late stages of the natural killer cell lytic reaction

1986 • 12 citations