Interleukin-1 Receptor Antagonist Gene Polymorphism and Coronary Artery Disease

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

1994 • 2,343 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

1992 • 1,956 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria

1994 • 1,199 citations

The interleukin‐1 genotype as a severity factor in adult periodontal disease

1997 • 1,198 citations

The metabolic basis of inherited disease

1995 • 1,007 citations

Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.

1984 • 944 citations

Essentials of medical statistics.

1988 • 934 citations

Single base polymorphism in the human Tumour Necrosis Factor alpha (TNFα) gene detectable by Ncol restriction of PCR product

1992 • 903 citations

Genetic and Environmental Influences on Premature Death in Adult Adoptees

1988 • 814 citations

Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat

1993 • 688 citations

An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.

1993 • 682 citations

Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.

1991 • 675 citations

Interleukin-1 Receptor Antagonist

1993 • 670 citations

Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism

1995 • 543 citations

Detection and localization of tumor necrosis factor in human atheroma

1990 • 453 citations

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist

1994 • 412 citations

Interleukin 1: the first interleukin

1990 • 342 citations

A genetic association between juvenile rheumatoid arthritis and a novel interleukin‐1α polymorphism

1995 • 327 citations

Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.

1997 • 312 citations

Interleukin-1β in Coronary Arteries of Patients With Ischemic Heart Disease

1996 • 307 citations

Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.

1996 • 302 citations

Inducible interleukin-1 gene expression in human vascular smooth muscle cells.

1986 • 256 citations

Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis.

1991 • 235 citations

Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.

1995 • 222 citations

Differential Effects of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein on Fatty-Streak Formation in Apolipoprotein E–Deficient Mice

1998 • 209 citations

Apolipoprotein ∈4 homozygosity in young men with coronary heart disease

1992 • 198 citations

Production of tumor necrosis factor and interleukin-1 by macrophages from human atheromatous plaques.

1993 • 186 citations

An Analysis of Linkage Disequilibrium in the Interleukin-1 Gene Cluster, Using a Novel Grouping Method for Multiallelic Markers

1998 • 182 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

Interleukin-1 receptor antagonist allele (ILIRN*2) associated with nephropathy in diabetes mellitus

1996 • 150 citations

Genetic aspects of arteriosclerosis.

1986 • 128 citations

Transforming growth factor-beta synthesis by human peritoneal mesothelial cells. Induction by interleukin-1.

1996 • 104 citations

Interactions between bacterial lipopolysaccharides and serum lipoproteins and their possible role in coronary heart disease.

1993 • 93 citations

Increased serum concentrations of interleukin-1 beta in patients with coronary artery disease.

1996 • 85 citations

Polymorphisms of Factor V, Factor VII, and Fibrinogen Genes

1997 • 75 citations

Is there a link between periodontal disease and coronary heart disease?

1998 • 62 citations

Polymorphisms at the 5'-end of the apolipoprotein AI gene and severity of coronary artery disease.

1996 • 60 citations

Assignment of human ?-galactosidase-A gene to 3p21.33 by fluorescence in situ hybridization

1993 • 60 citations

PEPTIDE REGULATORY FACTORS IN NON-MALIGNANT DISEASE

1989 • 53 citations

Relation between family history of coronary artery disease and coronary risk variables

1988 • 53 citations

Coronary heart disease in male twins. Hereditary and environmental factors in concordant and discordant pairs.

1970 • 46 citations

An Allele of the Interleukin-1 Receptor Antagonist as a Genetic Severity Factor in Alopecia Areata

1995 • 44 citations

Genetic Regulation of Fibrinogen

1995 • 39 citations