Activation of the Mitogen-Activated Protein Kinase p38 by Human Cytomegalovirus Infection through Two Distinct Pathways: a Novel Mechanism for Activation of p38

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

Rb Interacts with Histone Deacetylase to Repress Transcription

1998 • 965 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

The Cytomegaloviruses: Ubiquitous Agents with Protean Clinical Manifestations

1971 • 649 citations

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

1990 • 586 citations

Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review

1993 • 551 citations

Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

1998 • 524 citations

Regulation and function of the JNK subgroup of MAP kinases

1997 • 484 citations

The Cytomegaloviruses: Ubiquitous Agents with Protean Clinical Manifestations

1971 • 392 citations

Signaling by dual specificity kinases

1998 • 291 citations

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

1995 • 253 citations

Protein-Damaging Stresses Activate c-Jun N-Terminal Kinase via Inhibition of Its Dephosphorylation: a Novel Pathway Controlled by HSP72

1999 • 239 citations

Control of Protein Phosphatase 2A by Simian Virus 40 Small-t Antigen

1991 • 238 citations

Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b

1997 • 234 citations

MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction

1999 • 226 citations

Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements

1992 • 220 citations

Human Cytomegalovirus Inhibits Cellular DNA Synthesis and Arrests Productively Infected Cells in Late G1

1996 • 211 citations

The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection

1997 • 202 citations

Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro

1983 • 202 citations

Engagement of the Cellular Receptor for Glycoprotein B of Human Cytomegalovirus Activates the Interferon-Responsive Pathway

1999 • 200 citations

Human Cytomegalovirus Binding to Human Monocytes Induces Immunoregulatory Gene Expression

1999 • 180 citations

"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs

1994 • 180 citations

Herpes Simplex Virus Type 1 Infection Stimulates p38/c-Jun N-terminal Mitogen-activated Protein Kinase Pathways and Activates Transcription Factor AP-1

1999 • 169 citations

Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

1994 • 164 citations

Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection.

1993 • 151 citations

CREB-Mediated Transcriptional Control

1999 • 143 citations

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters

1997 • 141 citations

Activation of cJUN N-Terminal Kinase by Herpes Simplex Virus Type 1 Enhances Viral Replication

1999 • 137 citations

Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade

1999 • 129 citations

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

1999 • 121 citations

Extracellular Signal-Regulated Kinase Activity Is Sustained Early during Human Cytomegalovirus Infection

1998 • 107 citations

Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro

1998 • 100 citations

Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein

1997 • 99 citations

Molecular Aspects of Human Cytomegalovirus Diseases

1993 • 84 citations

Early Activation of Mitogen-Activated Protein Kinase Kinase, Extracellular Signal-Regulated Kinase, p38 Mitogen-Activated Protein Kinase, and c-JunN-Terminal Kinase in Response to Binding of Simian Immunodeficiency Virus to Jurkat T Cells Expressing CCR5 Receptor

1998 • 79 citations

Identification of sequence elements in the human cytomegalovirus DNA polymerase gene promoter required for activation by viral gene products

1994 • 51 citations

Human cytomegalovirus carries serine/threonine protein phosphatases PP1 and a host-cell derived PP2A

1996 • 48 citations

The Pathogenicity of Human Cytomegalovirus: An Overview

1993 • 48 citations

Inhibitory effect of 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole on HCMV DNA replication and permissive infection

1999 • 45 citations

Inhibitors of serine/threonine kinases

1995 • 43 citations

Treatment of Cytomegalovirus Retinitis in Patients with AIDS

1988 • 40 citations

Transcription by RNA polymerases I and III: a potential link between cell growth, protein synthesis and the retinoblastoma protein

1998 • 35 citations

Transcriptional Regulation of the Human Cytomegalovirus US11 Early Gene

1999 • 32 citations

Distinct Pathways for Tumor Necrosis Factor Alpha and Ceramides in Human Cytomegalovirus Infection

1998 • 23 citations

Comparative studies of the influence of various K+ concentrations on the action of K-strophanthidin, digitoxin and strophanthidin-3-bromoacetate on papillary muscle and on membrane-atpase of guinea pig hearts

1971 • 22 citations

The role of ATF in regulating the human cytomegalovirus DNA polymerase (UL54) promoter during viral infection

1997 • 21 citations

Clinical use of Antiviral Drugs

1987 • 21 citations

Signal Transduction Pathways and Modulation of Gene Activity

1998 • 8 citations

Clinical Use of Foscarnet (Phosphonoformate)

1988 • 5 citations