Role of apoptosis in the prognosis of oligodendrogliomas

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Grading of astrocytomas: A simple and reproducible method

1988 • 902 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Growth Kinetics of Tumours

1978 • 691 citations

Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice

1993 • 653 citations

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1992 • 600 citations

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

1994 • 560 citations

Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor

1993 • 433 citations

Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.

1996 • 360 citations

In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum

1993 • 331 citations

The p53 Gene and Protein in Human Brain Tumors

1994 • 303 citations

Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections.

1993 • 276 citations

Correlations between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas.

1993 • 222 citations

Growth Kinetics of Tumours: Cell Population Kinetics in Relation to the Growth and Treatment of Cancer

1978 • 207 citations

A Study of Apoptosis in Normal and Pathologic Nervous Tissue After In situ End-Labeling of DNA Strand Breaks

1994 • 205 citations

Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain

1994 • 197 citations

Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.

1993 • 177 citations

Apoptosis in bladder cancer as related to standard prognostic factors and prognosis

1994 • 143 citations

Induction of apoptosis at different oxygen tensions: evidence that oxygen radicals do not mediate apoptotic signaling.

1995 • 142 citations

Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes.

1994 • 140 citations

A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells

1995 • 138 citations

Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast

1992 • 126 citations

Ultrastructural detection of DNA strand breaks in apoptotic neural cells by in situ end‐labelling techniques

1995 • 112 citations

The involvement of oncogenes and tumor suppressor genes in the control of apoptosis

1992 • 99 citations

Apoptosis and cell proliferation in human neuroepithelial tumors

1995 • 96 citations

Human gliomas with wild-type p53 express bcl-2.

1995 • 94 citations

bcl-2 protein expression in tumors of the central nervous system

1994 • 76 citations

Comparative analysis ofp53 protein immunoreactivity in prostatic, lung and breast carcinomas

1992 • 62 citations

Assessment of cell proliferation in pathology—what next?

1995 • 60 citations

Apoptosis in cerebral astrocytic tumours and its relationship to expression of the bcl‐2 and p53 proteins

1995 • 60 citations

Animal Models of Medulloblastomas and Related Primitive Neuroectodermal Tumors. A Review

1995 • 53 citations

Increased expression of bcl-2 immunoreactivity in the developing cerebral cortex of the rat

1994 • 50 citations

Bcl-2 distribution in neuroepithelial tumors: an immunohistochemical study

1996 • 48 citations

Ionizing radiation-induced apoptosis is associated with c-Jun expression and c-Jun/AP-1 activation in the developing cerebellum of the rat

1995 • 30 citations