Studies on the Kinetic and Chemical Mechanism of Inhibition of Stromelysin by an N-(Carboxyalkyl)dipeptide

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

The Behavior and Significance of Slow‐Binding Enzyme Inhibitors

1988 • 828 citations

A novel coumarin‐labelled peptide for sensitive continuous assays of the matrix metalloproteinases

1992 • 692 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

[29] Solvent isotope effects on enzyme systems

1982 • 394 citations

The Proton Inventory Techniqu

1984 • 185 citations

Comparison of vertebrate collagenase and gelatinase using a new fluorogenic substrate peptide

1989 • 154 citations

Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by x-ray crystallography: a novel class of transition-state analogs for zinc peptidases

1984 • 153 citations

Structures and isotopic fractionation factors of complexes AHA-1

1977 • 133 citations

Continuously recording fluorescent assays optimized for five human matrix metalloproteinases

1991 • 111 citations

Deviations from Michaelis-Menten kinetics. The possibility of complicated curves for simple kinetic schemes and the computer fitting of experimental data for acetylcholinesterase, acid phosphatase, adenosine deaminase, arylsulphatase, benzylamine oxidase, chymotrypsin, fumarase, galactose dehydrogenase, β-galactosidase, lactate dehydrogenase, peroxidase and xanthine oxidase

1980 • 82 citations

Substrate specificity of the human matrix metalloproteinase stromelysin and the development of continuous fluorometric assays

1992 • 71 citations

Inhibition of angiotensin converting enzyme: dependence of chloride

1984 • 71 citations

The rate of formation of transition-state analogs in the active site of adenosine deaminase is encounter-controlled: implications for the mechanism

1992 • 57 citations

Mechanistic studies on the human matrix metalloproteinase stromelysin

1992 • 46 citations

Solvent deuterium isotope effect on the liver alcohol dehydrogenase reaction

1979 • 39 citations

Catalysis by human leukocyte elastase: the proton inventory as a mechanistic probe

1987 • 38 citations

Mechanistic studies on the inhibition of thermolysin by a peptide hydroxamic acid

1992 • 38 citations

A semicontinuous, high-performance liquid chromatography-based assay for stromelysin

1989 • 37 citations

Correlative variations in enzyme-derived and substrate-derived structures of catalytic transition states. Implications for the catalytic strategy of acyl-transfer enzymes

1983 • 35 citations

Substrate specificity of human fibroblast stromelysin. Hydrolysis of substance P and its analogs

1989 • 34 citations

Production and Purification of Prostromelysin and Procollagenase from IL-1 Beta-Stimulated Human Gingival Fibroblasts

1990 • 29 citations

Hydrogen/deuterium fractionation factors of the aqueous ligand of cobalt in Co(H2O)62+ and Co(II)-substituted carbonic anhydrase

1989 • 27 citations

Transition-state structural features for the association of metalloproteases with phosphorus-containing inhibitors

1992 • 19 citations

In vivo activity of human recombinant tissue inhibitor of metalloproteinases (TIMP)

1990 • 19 citations

Transition-state properties for the association of .alpha.-1-protease inhibitor with porcine pancreatic elastase

1985 • 13 citations

Mechanistic studies on the inhibition of stromelysin by a peptide phosphonamidate

1993 • 13 citations

Catalysis by human leukocyte elastase. 5. Structural features of the virtual transition state for acylation

1985 • 11 citations