The rate of formation of transition-state analogs in the active site of adenosine deaminase is encounter-controlled: implications for the mechanism

Investigation of rates and mechanisms of reactions

1961 • 612 citations

Analog approaches to the structure of the transition state in enzyme reactions

1972 • 599 citations

Analysis of numerical methods for computer simulation of kinetic processes: Development of KINSIM—A flexible, portable system

1983 • 597 citations

Atomic Structure of Adenosine Deaminase Complexed with a Transition-State Analog: Understanding Catalysis and Immunodeficiency Mutations

1991 • 430 citations

Analysis of progress curves by simulations generated by numerical integration

1989 • 232 citations

Thiation of Nucleosides. I. Synthesis of 2-Amino-6-mercapto-9-β-D-ribofuranosylpurine (“Thioguanosine”) and Related Purine Nucleosides¹

1958 • 193 citations

The Proton Inventory Techniqu

1984 • 185 citations

Use of Isotope Effects to Elucidate Enzyme Mechanism

1982 • 167 citations

Adenosine deaminase and adenylate deaminase: comparative kinetic studies with transition state and ground state analog inhibitors

1980 • 126 citations

Possible role for water dissociation in the slow binding of phosphorus-containing transition-state-analog inhibitors of thermolysin

1987 • 114 citations

Transition state stabilization by deaminases: Rates of nonenzymatic hydrolysis of adenosine and cytidine

1987 • 89 citations

Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase

1987 • 64 citations

Adenosine deaminase: viscosity studies and the mechanism of binding of substrate and of ground- and transition-state analog inhibitors

1987 • 61 citations

Metazidohemerythrin models featuring a bis-benzimidazole tripod ligand. Structure and spectroscopy of .mu.-oxobis(.mu.-benzoato)bis(bis(2-benzimidazolylmethyl)amine)diiron(III)

1988 • 57 citations

Major Enhancement of the Affinity of an Enzyme for a Transition-State Analog by a Single Hydroxyl Group

1989 • 51 citations

Transition-state stabilization by adenosine deaminase: 1,6-addition of water to purine ribonucleoside, the enzyme's affinity for 6-hydroxy-1,6-dihydropurine ribonucleoside, and the effective concentration of substrate water at the active site

1989 • 46 citations

Improved synthesis and antitumor activity of 1-deazaadenosine

1987 • 46 citations

Adenosine deaminase converts purine riboside into an analog of a reactive intermediate: a carbon-13 NMR and kinetic study

1987 • 44 citations

Mechanistic studies of thermolysin

1990 • 43 citations

Adenosine deaminase: solvent isotope and pH effects on the binding of transition-state and ground-state analog inhibitors

1983 • 41 citations

Calibration of stopped-flow spectrophotometers using a two-step disulfide exchange reaction

1980 • 36 citations

The stereoselective enzymatic synthesis of 9-β-d-2′-deoxyribofuranosyl 1-deazapurine

1989 • 34 citations

Deaza Analogues of Adenosine as Inhibitors of Blood Platelet Aggregation

1984 • 32 citations

Catalysis of the covalent hydration of pteridine by adenosine aminohydrolase

1973 • 31 citations

Protein structural changes accompanying formation of enzymic transition states: tryptophan environment in ground-state and transition-state analog complexes of adenosine deaminase

1985 • 31 citations

Immunoaffinity purification and fluorescence studies of human adenosine deaminase

1987 • 25 citations

Studies on the chemical synthesis of potential antimetabolites. 30. Regioselective introduction of a chlorine atom into the imidazo[4,5‐b]pyridine nucleus

1982 • 21 citations

A quantum chemical study of the enzymatic deamination of benzoadenine derivatives

1990 • 20 citations

Inhibition of Adenosine Deaminase From Several Sources by Deaza Derivatives of Adenosine and Ehna

1985 • 19 citations

Deuterium/protium fractionation factors for polyfunctional organic molecules. Direct determination by carbon-13 NMR spectroscopy

1986 • 18 citations

Nebularine, 9-β-<scp>D</scp>-ribofuranosylpurine

1974 • 15 citations

Transition-state structural features for the thermolysin-catalyzed hydrolysis of N-(3-[2-furyl]acryloyl)-Gly-LeuNH2

1988 • 15 citations

Solvent isotope effects on equilibriums of mono- and dihydration of neutral pteridine

1983 • 11 citations

Fractionation of deuterium and protium between water and methanol

1984 • 10 citations

The protonated form of 1‐N⁶‐etheno‐[erythro‐9‐(2‐hydroxy‐3‐nonyl)] adenine is identified at the active site of adenosine deaminase

1990 • 10 citations

A Novel Synthesis of 1-Deazaadenosine

1982 • 7 citations